LipidDB ID

LipidDB-10116-00619

Entry Name

UniProt Accession

Q99M64;

Theoretical PI

8.28

Molecular Weight

54304.78

Genbank Protein ID

AAK33002.1;

Genbank Nucleotide ID

AY029199;

Protein Name

Phosphatidylinositol 4-kinase type 2-alpha

Protein Synonyms/Alias

2.7.1.67; 55 kDa type II phosphatidylinositol 4-kinase; Phosphatidylinositol 4-kinase type II-alpha;

Gene Name

Pi4k2a

Gene Synonyms/Alias

Pi4kii;

Created Date

01-MAY-2007

Organism

Rattus norvegicus (Rat)

NCBI Taxa ID

10116

Reference

[1] Barylko B, Mao YS, Wlodarski P, Jung G, Binns DD, Sun HQ, Yin HL, Albanesi JP.Palmitoylation controls the catalytic activity and subcellular distribution ofphosphatidylinositol 4-kinase II{alpha}. J Biol Chem. 2009 Apr10;284(15):9994-10003. doi: 10.1074/jbc.M900724200. Epub 2009 Feb 11. PubMedPMID: 19211550; PubMed Central PMCID: PMC2665123.[PMID:19211550]

Functional Description

Together with PI4K2B and the type III PI4Ks (PIK4CA and PIK4CB) it contributes to the overall PI4-kinase activity of the cell. The phosphorylation of phosphatidylinositol (PI) to PI4P is the first committed step in the generation of phosphatidylinositol 4,5-bisphosphate (PIP2), a precursor of the second messenger inositol 1,4,5-trisphosphate (InsP3). Contributes to the production of InsP3 in stimulated cells. This lipid kinase is the major phosphatidylinositol 4-phosphate (PI4P) producer in the Golgi apparatus, it generates more than 50% of this molecule which is essential for the identity of the organelle, protein sorting and membrane trafficking.

Sequence Annotation

Domain: 132 437 PI3K/PI4K.
Modified residue: 1 1 N-acetylmethionine.
Modified residue: 5 5 Phosphoserine.
Modified residue: 9 9 Phosphoserine.
Modified residue: 46 46 Phosphoserine.
Modified residue: 50 50 Phosphoserine.
Modified residue: 461 461 Phosphoserine.
Modified residue: 463 463 Phosphoserine.

Protein Length

478 AA.

Protein Sequence
(Canonical)

FASTA
(Canonical)

Gene Ontology

GO:0031083; C:BLOC-1 complex; IEA:Ensembl
GO:0030054; C:cell junction; IEA:UniProtKB-KW
GO:0031410; C:cytoplasmic vesicle; IDA:UniProtKB
GO:0030425; C:dendrite; ISS:UniProtKB
GO:0031901; C:early endosome membrane; IDA:RGD
GO:0005768; C:endosome; IDA:UniProtKB
GO:0070382; C:exocytic vesicle; IDA:RGD
GO:0005794; C:Golgi apparatus; IEA:UniProtKB-KW
GO:0035838; C:growing cell tip; IDA:UniProtKB
GO:0044231; C:host cell presynaptic membrane; ISS:UniProtKB
GO:0005887; C:integral component of plasma membrane; IEA:Ensembl
GO:0043231; C:intracellular membrane-bounded organelle; IDA:RGD
GO:0005765; C:lysosomal membrane; IEA:Ensembl
GO:0045121; C:membrane raft; IDA:RGD
GO:0005739; C:mitochondrion; ISS:UniProtKB
GO:0043005; C:neuron projection; IDA:UniProtKB
GO:0043025; C:neuronal cell body; IDA:UniProtKB
GO:0043204; C:perikaryon; IDA:RGD
GO:0005886; C:plasma membrane; IDA:RGD
GO:0042734; C:presynaptic membrane; ISS:UniProtKB
GO:0043234; C:protein complex; IDA:RGD
GO:0030672; C:synaptic vesicle membrane; IDA:RGD
GO:0004430; F:1-phosphatidylinositol 4-kinase activity; IDA:RGD
GO:0035651; F:AP-3 adaptor complex binding; ISS:UniProtKB
GO:0005524; F:ATP binding; IEA:UniProtKB-KW
GO:0032403; F:protein complex binding; IDA:RGD
GO:0002561; P:basophil degranulation; IMP:RGD
GO:0006661; P:phosphatidylinositol biosynthetic process; IEA:Ensembl
GO:0046854; P:phosphatidylinositol phosphorylation; IDA:GOC

Interpro

InterPro; IPR000403; PI3/4_kinase_cat_dom

Pfam

Pfam; PF00454; PI3_PI4_kinase;

SMART

PROSITE

PRINTS