| Tag |
Content |
LipidDB ID |
LipidDB-10116-00597 |
Entry Name |
|
UniProt Accession |
|
Theoretical PI |
9.09 |
Molecular Weight |
47054.54 |
Genbank Protein ID |
|
Genbank Nucleotide ID |
|
Protein Name |
Neurotensin receptor type 1 |
Protein Synonyms/Alias |
NT-R-1; NTR1; High-affinity levocabastine-insensitive neurotensin receptor; NTRH; |
Gene Name |
Ntsr1 |
Gene Synonyms/Alias |
Ntsr; |
Created Date |
01-FEB-1991 |
| Lipid Modification Sites |
|---|
| Position |
Sequence Form |
Peptide |
References |
Modification Type |
386 | Canonical | VFLSTLACLCPGWRH | [1] | S-Palmitoylation | 388 | Canonical | LSTLACLCPGWRHRR | [1] | S-Palmitoylation |
|
Organism |
Rattus norvegicus (Rat) |
NCBI Taxa ID |
10116 |
Reference |
[1] Egloff P, Hillenbrand M, Klenk C, Batyuk A, Heine P, Balada S, Schlinkmann KM,Scott DJ, Schütz M, Plückthun A. Structure of signaling-competent neurotensinreceptor 1 obtained by directed evolution in Escherichia coli. Proc Natl Acad SciU S A. 2014 Feb 11;111(6):E655-62. doi: 10.1073/pnas.1317903111. Epub 2014 Jan22.[ PMID:24453215]
|
Functional Description |
G-protein coupled receptor for the tridecapeptide neurotensin (NTS). Signaling is effected via G proteins that activate a phosphatidylinositol-calcium second messenger system. Signaling leads to the activation of downstream MAP kinases and protects cells against apoptosis. |
Sequence Annotation |
Topological domain: 1 68 Extracellular.
Transmembrane: 69 89 Helical; Name=1.
Topological domain: 90 103 Cytoplasmic.
Transmembrane: 104 123 Helical; Name=2.
Topological domain: 124 143 Extracellular.
Transmembrane: 144 165 Helical; Name=3.
Topological domain: 166 188 Cytoplasmic.
Transmembrane: 189 210 Helical; Name=4.
Topological domain: 211 235 Extracellular.
Transmembrane: 236 260 Helical; Name=5.
Topological domain: 261 308 Cytoplasmic.
Transmembrane: 309 330 Helical; Name=6.
Topological domain: 331 348 Extracellular.
Transmembrane: 349 369 Helical; Name=7.
Topological domain: 370 424 Cytoplasmic.
Region: 326 349 Neurotensin binding.
|
Protein Length |
424 AA. |
Protein Sequence
(Canonical) |
MHLNSSVPQG TPGEPDAQPF SGPQSEMEAT FLALSLSNGS GNTSESDTAG PNSDLDVNTD 60
IYSKVLVTAI YLALFVVGTV GNSVTAFTLA RKKSLQSLQS TVHYHLGSLA LSDLLILLLA 120
MPVELYNFIW VHHPWAFGDA GCRGYYFLRD ACTYATALNV ASLSVERYLA ICHPFKAKTL 180
MSRSRTKKFI SAIWLASALL AIPMLFTMGL QNRSGDGTHP GGLVCTPIVD TATVKVVIQV 240
NTFMSFLFPM LVISILNTVI ANKLTVMVHQ AAEQGRVCTV GTHNGLEHST FNMTIEPGRV 300
QALRHGVLVL RAVVIAFVVC WLPYHVRRLM FCYISDEQWT TFLFDFYHYF YMLTNALFYV 360
SSAINPILYN LVSANFRQVF LSTLACLCPG WRHRRKKRPT FSRKPNSMSS NHAFSTSATR 420
ETLY 424
|
FASTA
(Canonical) |
>LipidDB-10116-00597|P20789
MHLNSSVPQGTPGEPDAQPFSGPQSEMEATFLALSLSNGSGNTSESDTAGPNSDLDVNTD
IYSKVLVTAIYLALFVVGTVGNSVTAFTLARKKSLQSLQSTVHYHLGSLALSDLLILLLA
MPVELYNFIWVHHPWAFGDAGCRGYYFLRDACTYATALNVASLSVERYLAICHPFKAKTL
MSRSRTKKFISAIWLASALLAIPMLFTMGLQNRSGDGTHPGGLVCTPIVDTATVKVVIQV
NTFMSFLFPMLVISILNTVIANKLTVMVHQAAEQGRVCTVGTHNGLEHSTFNMTIEPGRV
QALRHGVLVLRAVVIAFVVCWLPYHVRRLMFCYISDEQWTTFLFDFYHYFYMLTNALFYV
SSAINPILYNLVSANFRQVFLSTLACLCPGWRHRRKKRPTFSRKPNSMSSNHAFSTSATR
ETLY
|
Gene Ontology |
GO:0005887; C:integral component of plasma membrane; ISS:UniProtKB GO:0045121; C:membrane raft; ISS:UniProtKB GO:0016492; F:G-protein coupled neurotensin receptor activity; ISS:UniProtKB GO:0008344; P:adult locomotory behavior; IEA:Ensembl GO:0043066; P:negative regulation of apoptotic process; ISS:UniProtKB GO:0007218; P:neuropeptide signaling pathway; ISS:GOC |
Interpro |
|
Pfam |
|
SMART |
|
PROSITE |
PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; |
PRINTS |
|