Lipid Modification Database
Tag Content
LipidDB ID
LipidDB-10116-00552
Entry Name
UniProt Accession
Theoretical PI
5.1
Molecular Weight
26817.4
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
Kv channel-interacting protein 1
Protein Synonyms/Alias
KChIP1; A-type potassium channel modulatory protein 1; Potassium channel-interacting protein 1;
Gene Name
Kcnip1
Gene Synonyms/Alias
Kchip1;
Created Date
16-AUG-2005
 Lipid Modification Sites 
 Position   Sequence Form   Peptide   References   Modification Type 
2
Canonical
******MGAVMGTFS
[1]
N-Myristoylation
Organism
Rattus norvegicus (Rat)
NCBI Taxa ID
10116
Reference
[1] O'Callaghan DW, Burgoyne RD. Role of myristoylation in the intracellulartargeting of neuronal calcium sensor (NCS) proteins. Biochem Soc Trans. 2003Oct;31(Pt 5):963-5. Review.[PMID:14505460]
Functional Description
Regulatory subunit of Kv4/D (Shal)-type voltage-gated rapidly inactivating A-type potassium channels. Probably modulates channels density, inactivation kinetics and rate of recovery from inactivation in a calcium-dependent and isoform-specific manner. In vitro, modulates KCND1/Kv4.1 and KCND2/Kv4.2 currents. Seems to be involved in KCND2 trafficking to the cell surface (By similarity).
Sequence Annotation
Domain: 38 94 EF-hand 1; degenerate.
Domain: 97 132 EF-hand 2.
Domain: 133 168 EF-hand 3.
Domain: 181 216 EF-hand 4.
Region: 214 227 Interaction with KCND2.
Protein Length
227 AA.
Protein Sequence
(Canonical)
MGAVMGTFSS LQTKQRRPSK DIAWWYYQYQ RDKIEDDLEM TMVCHRPEGL EQLEAQTNFT  60
KRELQVLYRG FKNECPSGVV NEETFKQIYA QFFPHGDAST YAHYLFNAFD TTQTGSVKFE  120
DFVTALSILL RGTVHEKLRW TFNLYDINKD GYINKEEMMD IVKAIYDMMG KYTYPVLKED  180
TPRQHVDVFF QKMDKNKDGI VTLDEFLESC QEDDNIMRSL QLFQNVM                227
FASTA
(Canonical)
>LipidDB-10116-00552|Q8R426
MGAVMGTFSSLQTKQRRPSKDIAWWYYQYQRDKIEDDLEMTMVCHRPEGLEQLEAQTNFT
KRELQVLYRGFKNECPSGVVNEETFKQIYAQFFPHGDASTYAHYLFNAFDTTQTGSVKFE
DFVTALSILLRGTVHEKLRWTFNLYDINKDGYINKEEMMDIVKAIYDMMGKYTYPVLKED
TPRQHVDVFFQKMDKNKDGIVTLDEFLESCQEDDNIMRSLQLFQNVM
Gene Ontology
GO:0030425; C:dendrite; IDA:RGD
GO:0043025; C:neuronal cell body; IDA:RGD
GO:0005886; C:plasma membrane; IDA:RGD
GO:0034705; C:potassium channel complex; IDA:RGD
GO:0005509; F:calcium ion binding; IDA:RGD
GO:0044325; F:ion channel binding; IPI:RGD
GO:0005267; F:potassium channel activity; IEA:UniProtKB-KW
GO:0015459; F:potassium channel regulator activity; IDA:RGD
GO:0046982; F:protein heterodimerization activity; IDA:RGD
GO:0047485; F:protein N-terminus binding; IPI:RGD
GO:0005244; F:voltage-gated ion channel activity; IEA:UniProtKB-KW
GO:0045760; P:positive regulation of action potential; IDA:RGD
Interpro
InterPro; IPR011992; EF-hand-dom_pair
InterPro; IPR018247; EF_Hand_1_Ca_BS
InterPro; IPR002048; EF_hand_dom
InterPro; IPR028846; Recoverin
Pfam
Pfam; PF13499; EF-hand_7;
SMART
SMART; SM00054; EFh;
PROSITE
PROSITE; PS00018; EF_HAND_1;
PROSITE; PS50222; EF_HAND_2;
PRINTS