LipidDB ID

LipidDB-10116-00535

Entry Name

UniProt Accession

Q6RUV5;

Theoretical PI

8.77

Molecular Weight

21450.11

Genbank Protein ID

AAR84574.1;

Genbank Nucleotide ID

AY491395;

Protein Name

Ras-related C3 botulinum toxin substrate 1

Protein Synonyms/Alias

p21-Rac1;

Gene Name

Rac1

Gene Synonyms/Alias

Created Date

31-AUG-2004

Organism

Rattus norvegicus (Rat)

NCBI Taxa ID

10116

Reference

[1] Predicted from GPS-Lipid

Functional Description

Plasma membrane-associated small GTPase which cycles between active GTP-bound and inactive GDP-bound states. In its active state, binds to a variety of effector proteins to regulate cellular responses such as secretory processes, phagocytosis of apoptotic cells, epithelial cell polarization and growth-factor induced formation of membrane ruffles. Rac1 p21/rho GDI heterodimer is the active component of the cytosolic factor sigma 1, which is involved in stimulation of the NADPH oxidase activity in macrophages. Essential for the SPATA13-mediated regulation of cell migration and adhesion assembly and disassembly. Stimulates PKN2 kinase activity. In concert with RAB7A, plays a role in regulating the formation of RBs (ruffled borders) in osteoclasts. In glioma cells, promotes cell migration and invasion. In podocytes, promotes nuclear shuttling of NR3C2; this modulation is required for a proper kidney functioning. Required for atypical chemokine receptor ACKR2-induced LIMK1-PAK1-dependent phosphorylation of cofilin (CFL1) and for up-regulation of ACKR2 from endosomal compartment to cell membrane, increasing its efficiency in chemokine uptake and degradation. In synapses, seems to mediate the regulation of F-actin cluster formation performed by SHANK3.

Sequence Annotation

Nucleotide-binding: 10 17 GTP.
Nucleotide-binding: 57 61 GTP.
Nucleotide-binding: 115 118 GTP.
Motif: 32 40 Effector region.
Modified residue: 189 189 Cysteine methyl ester.

Protein Length

192 AA.

Protein Sequence
(Canonical)

FASTA
(Canonical)

Gene Ontology

GO:0005737; C:cytoplasm; IDA:RGD
GO:0016023; C:cytoplasmic membrane-bounded vesicle; IEA:Ensembl
GO:0031410; C:cytoplasmic vesicle; IDA:RGD
GO:0005829; C:cytosol; IDA:UniProtKB
GO:0070062; C:extracellular vesicular exosome; IEA:Ensembl
GO:0019897; C:extrinsic component of plasma membrane; IEA:Ensembl
GO:0000139; C:Golgi membrane; IDA:RGD
GO:0030027; C:lamellipodium; IEA:Ensembl
GO:0016020; C:membrane; IDA:UniProtKB
GO:0001891; C:phagocytic cup; IEA:Ensembl
GO:0032587; C:ruffle membrane; IEA:Ensembl
GO:0005802; C:trans-Golgi network; IEA:Ensembl
GO:0005525; F:GTP binding; IDA:RGD
GO:0003924; F:GTPase activity; IDA:RGD
GO:0019901; F:protein kinase binding; IPI:BHF-UCL
GO:0017137; F:Rab GTPase binding; IPI:RGD
GO:0030036; P:actin cytoskeleton organization; IDA:RGD
GO:0007015; P:actin filament organization; IMP:RGD
GO:0030041; P:actin filament polymerization; IEA:Ensembl
GO:0048532; P:anatomical structure arrangement; IEA:Ensembl
GO:0002093; P:auditory receptor cell morphogenesis; IEA:Ensembl
GO:0007411; P:axon guidance; IEA:Ensembl
GO:0045453; P:bone resorption; IDA:RGD
GO:0048870; P:cell motility; ISS:UniProtKB
GO:0008283; P:cell proliferation; IMP:RGD
GO:0045216; P:cell-cell junction organization; IEA:Ensembl
GO:0006928; P:cellular component movement; IMP:RGD
GO:0021799; P:cerebral cortex radially oriented cell migration; IEA:Ensembl
GO:0006935; P:chemotaxis; IMP:RGD
GO:0090103; P:cochlea morphogenesis; IEA:Ensembl
GO:0048813; P:dendrite morphogenesis; IEA:Ensembl
GO:0071542; P:dopaminergic neuron differentiation; IEA:Ensembl
GO:0021831; P:embryonic olfactory bulb interneuron precursor migration; IEA:Ensembl
GO:0043652; P:engulfment of apoptotic cell; IEA:Ensembl
GO:0003382; P:epithelial cell morphogenesis; IEA:Ensembl
GO:0007186; P:G-protein coupled receptor signaling pathway; IEA:Ensembl
GO:0006184; P:GTP catabolic process; IDA:GOC
GO:0006972; P:hyperosmotic response; IEA:Ensembl
GO:0030032; P:lamellipodium assembly; IEA:Ensembl
GO:0051668; P:localization within membrane; IEA:Ensembl
GO:0002551; P:mast cell chemotaxis; IMP:RGD
GO:0032707; P:negative regulation of interleukin-23 production; IEA:Ensembl
GO:0030838; P:positive regulation of actin filament polymerization; IEA:Ensembl
GO:0045740; P:positive regulation of DNA replication; IMP:RGD
GO:0010592; P:positive regulation of lamellipodium assembly; IEA:Ensembl
GO:0043552; P:positive regulation of phosphatidylinositol 3-kinase activity; IEA:Ensembl
GO:0001934; P:positive regulation of protein phosphorylation; ISS:UniProtKB
GO:0072659; P:protein localization to plasma membrane; IEA:Ensembl
GO:0016601; P:Rac protein signal transduction; TAS:RGD
GO:0030334; P:regulation of cell migration; ISS:UniProtKB
GO:0060263; P:regulation of respiratory burst; IEA:Ensembl
GO:0097178; P:ruffle assembly; IEA:Ensembl
GO:0071526; P:semaphorin-plexin signaling pathway; IMP:UniProtKB
GO:0034446; P:substrate adhesion-dependent cell spreading; IEA:Ensembl
GO:0060071; P:Wnt signaling pathway, planar cell polarity pathway; IEA:Ensembl

Interpro

InterPro; IPR027417; P-loop_NTPase
InterPro; IPR005225; Small_GTP-bd_dom
InterPro; IPR001806; Small_GTPase
InterPro; IPR003578; Small_GTPase_Rho

Pfam

Pfam; PF00071; Ras;

SMART

SMART; SM00174; RHO;

PROSITE

PROSITE; PS51420; RHO;

PRINTS

PRINTS; PR00449; RASTRNSFRMNG;