LipidDB ID

LipidDB-10116-00517

Entry Name

UniProt Accession

Q9R066; Q5M817; Q9R067;

Theoretical PI

6.94

Molecular Weight

39948.61

Genbank Protein ID

AAF01254.1; AAF01255.1; AAH88313.1;

Genbank Nucleotide ID

AABR03078554; AABR03079390; AF109643; AF109644; BC088313;

Protein Name

Coxsackievirus and adenovirus receptor homolog

Protein Synonyms/Alias

CAR; rCAR;

Gene Name

Cxadr

Gene Synonyms/Alias

Car;

Created Date

19-JUL-2005

Organism

Rattus norvegicus (Rat)

NCBI Taxa ID

10116

Reference

[1] Predicted from GPS-Lipid

Functional Description

Component of the epithelial apical junction complex that may function as an homophilic cell adhesion molecule and is essential for tight junction integrity. Also involved in transepithelial migration of leukocytes through adhesive interactions with AMICA1/JAML a transmembrane protein of the plasma membrane of leukocytes. The interaction between both receptors also mediates the activation of gamma-delta T-cells, a subpopulation of T-cells residing in epithelia and involved in tissue homeostasis and repair. Upon epithelial CXADR-binding, AMICA1 induces downstream cell signaling events in gamma-delta T- cells through PI3-kinase and MAP kinases. It results in proliferation and production of cytokines and growth factors by T- cells that in turn stimulate epithelial tissues repair (By similarity).

Sequence Annotation

Topological domain: 20 238 Extracellular.
Transmembrane: 239 259 Helical.
Topological domain: 260 365 Cytoplasmic.
Domain: 20 136 Ig-like C2-type 1.
Domain: 141 228 Ig-like C2-type 2.
Motif: 360 365 PDZ-binding.
Modified residue: 306 306 Phosphoserine.
Modified residue: 323 323 Phosphoserine.
Modified residue: 332 332 Phosphoserine.

Protein Length

365 AA.

Protein Sequence
(Canonical)

FASTA
(Canonical)

Gene Ontology

GO:0001669; C:acrosomal vesicle; ISS:UniProtKB
GO:0005912; C:adherens junction; ISS:UniProtKB
GO:0016327; C:apicolateral plasma membrane; ISS:UniProtKB
GO:0044297; C:cell body; ISS:UniProtKB
GO:0005737; C:cytoplasm; ISS:UniProtKB
GO:0030175; C:filopodium; ISS:UniProtKB
GO:0030426; C:growth cone; ISS:UniProtKB
GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW
GO:0014704; C:intercalated disc; IEA:Ensembl
GO:0045121; C:membrane raft; ISS:UniProtKB
GO:0043005; C:neuron projection; IDA:UniProtKB
GO:0005634; C:nucleus; ISS:UniProtKB
GO:0005886; C:plasma membrane; ISS:UniProtKB
GO:0005923; C:tight junction; IDA:UniProtKB
GO:0008013; F:beta-catenin binding; ISS:UniProtKB
GO:0050839; F:cell adhesion molecule binding; ISS:UniProtKB
GO:0071253; F:connexin binding; ISS:UniProtKB
GO:0030165; F:PDZ domain binding; ISS:UniProtKB
GO:0001618; F:virus receptor activity; TAS:RGD
GO:0031532; P:actin cytoskeleton reorganization; ISS:UniProtKB
GO:0086067; P:AV node cell to bundle of His cell communication; ISS:UniProtKB
GO:0048739; P:cardiac muscle fiber development; ISS:UniProtKB
GO:0045216; P:cell-cell junction organization; ISS:UniProtKB
GO:0010669; P:epithelial structure maintenance; ISS:UniProtKB
GO:0046629; P:gamma-delta T cell activation; ISS:UniProtKB
GO:0008354; P:germ cell migration; ISS:UniProtKB
GO:0007507; P:heart development; ISS:UniProtKB
GO:0007157; P:heterophilic cell-cell adhesion; ISS:UniProtKB
GO:0034109; P:homotypic cell-cell adhesion; ISS:UniProtKB
GO:0007005; P:mitochondrion organization; ISS:UniProtKB
GO:0060044; P:negative regulation of cardiac muscle cell proliferation; IEA:Ensembl
GO:0030593; P:neutrophil chemotaxis; ISS:UniProtKB
GO:0009615; P:response to virus; TAS:GOC

Interpro

InterPro; IPR007110; Ig-like_dom
InterPro; IPR013783; Ig-like_fold
InterPro; IPR003599; Ig_sub
InterPro; IPR003598; Ig_sub2
InterPro; IPR013106; Ig_V-set

Pfam

Pfam; PF07686; V-set;

SMART

SMART; SM00409; IG;
SMART; SM00408; IGc2;

PROSITE

PROSITE; PS50835; IG_LIKE;

PRINTS