Functions as a sorting receptor in the Golgi compartment and as a clearance receptor on the cell surface. Required for protein transport from the Golgi apparatus to the lysosomes by a pathway that is independent of the mannose-6-phosphate receptor (M6PR). Also required for protein transport from the Golgi apparatus to the endosomes. Promotes neuronal apoptosis by mediating endocytosis of the proapoptotic precursor forms of BDNF (proBDNF) and NGFB (proNGFB). Also acts as a receptor for neurotensin. May promote mineralization of the extracellular matrix during osteogenic differentiation by scavenging extracellular LPL. Probably required in adipocytes for the formation of specialized storage vesicles containing the glucose transporter SLC2A4/GLUT4 (GLUT4 storage vesicles, or GSVs). These vesicles provide a stable pool of SLC2A4 and confer increased responsiveness to insulin. May also mediate transport from the endoplasmic reticulum to the Golgi.
Sequence Annotation
Topological domain: 76 754 Extracellular. Transmembrane: 755 775 Helical. Topological domain: 776 825 Cytoplasmic. Region: 48 59 Intrachain binding of the propeptide andthe extracellular domain. Region: 610 754 Interactions with LRPAP1 and NGFB. Region: 777 825 Golgi to endosome transport andinteractions with GGA1 and GGA2. Motif: 785 790 Endocytosis signal. Modified residue: 813 813 Phosphoserine. Modified residue: 819 819 Phosphoserine.