| Tag |
Content |
LipidDB ID |
LipidDB-10116-00487 |
Entry Name |
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UniProt Accession |
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Theoretical PI |
6.16 |
Molecular Weight |
98730.68 |
Genbank Protein ID |
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Genbank Nucleotide ID |
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Protein Name |
Prostaglandin F2 receptor negative regulator |
Protein Synonyms/Alias |
Prostaglandin F2-alpha receptor regulatory protein; Prostaglandin F2-alpha receptor-associated protein; CD315; |
Gene Name |
Ptgfrn |
Gene Synonyms/Alias |
Fprp; |
Created Date |
01-NOV-1997 |
| Lipid Modification Sites |
|---|
| Position |
Sequence Form |
Peptide |
References |
Modification Type |
19 | Canonical | ALLSLAVCRGRVVRV | [1] | S-Palmitoylation | 858 | Canonical | GYCSSHWCCKKEVRE | [1] | S-Palmitoylation |
|
Organism |
Rattus norvegicus (Rat) |
NCBI Taxa ID |
10116 |
Reference |
[1] Predicted from GPS-Lipid
|
Functional Description |
Inhibits the binding of prostaglandin F2-alpha (PGF2- alpha) to its specific FP receptor, by decreasing the receptor number rather than the affinity constant. Functional coupling with the prostaglandin F2-alpha receptor seems to occur. |
Sequence Annotation |
Topological domain: 22 832 Extracellular.
Transmembrane: 833 853 Helical.
Topological domain: 854 879 Cytoplasmic.
Domain: 22 129 Ig-like C2-type 1.
Domain: 149 268 Ig-like C2-type 2.
Domain: 276 389 Ig-like C2-type 3.
Domain: 406 527 Ig-like C2-type 4.
Domain: 544 662 Ig-like C2-type 5.
Domain: 688 813 Ig-like C2-type 6.
Motif: 89 91 Cell attachment site.
Motif: 424 427 Endoplasmic reticulum retention signal.
Motif: 703 705 Cell attachment site.
Modified residue: 271 271 Phosphothreonine.
|
Protein Length |
879 AA. |
Protein Sequence
(Canonical) |
MGRPAPRPLL LALLSLAVCR GRVVRVPAGT LVRVVGTELV IPCNVSDYDG PSEQNFDWSF 60
SSSGSSFVEL ASTWEVGFPA QQYRERLQRG DILLRRTAND AVELHIKNVQ PSDQGHYKCS 120
TPSTDATVQG NYEDTMQVKV LADALVVGPS SRPPPGLSLR EGEPFELRCI ASTTSPLHTH 180
LALRWELHRG PVHRSILALS HEGRFHPGPG YEQRYHSGDV RLDTVGSDAY RLSVARALSA 240
DQGSYRCVVS EWITEQGSWQ EIQEKAVEVA TVVIQPTALQ LAVPRTVSVT EGKDLDLSCN 300
ITTDRVDDVR PEVTWYFKKT PDTSLLASHM LARLDRDSLV HSSPHVALSH VDTRSYHLLV 360
RDVSKENSGY YLCLVALWAP GHNRSWHKVA EAMSAPSGVS VTWLEPEYQV YLNASKVPGF 420
SDDPTELQCR VIDTKRVDAG VRLTVSWYYR MNRRNDDVVA SELLAVMDGD WTLRYGERSK 480
QRAQDGEFIF SKEHTDTFSF RIQRTTEEDR GSYYCVVSAW TRQRNSSWVK SKDVFSKPVN 540
IFWASEDSVL VVKARQPKPF FAAGNTFEMT CKVSSKNIKS PRYSVLITAE KPVGDLSSPN 600
ETKYIISLDQ DSVVKLENWT DASRVDGVVL EKVQEDEFRY RMYQTQVSDA GLYRCMVTAW 660
SPIGGSLWRE AATSLSNPIE IDFQTSGPIF NASVHSDTLS VTRGDLIKLF CIVTVDGAVL 720
DPDDMAFDVS WFAVHSFGLD KAPILLSSLD RKGVVTTGQR DWKSTVSLER VSVLEFLLQV 780
HSSEDQDFGN YYCSVTPWVR SPTGSWQREA EIHSRPIFIT VKMDVLNAFK YPLLIGVGLS 840
TVIGLLSCLI GYCSSHWCCK KEVRETRRER RRLMSMEMD 879
|
FASTA
(Canonical) |
>LipidDB-10116-00487|Q62786
MGRPAPRPLLLALLSLAVCRGRVVRVPAGTLVRVVGTELVIPCNVSDYDGPSEQNFDWSF
SSSGSSFVELASTWEVGFPAQQYRERLQRGDILLRRTANDAVELHIKNVQPSDQGHYKCS
TPSTDATVQGNYEDTMQVKVLADALVVGPSSRPPPGLSLREGEPFELRCIASTTSPLHTH
LALRWELHRGPVHRSILALSHEGRFHPGPGYEQRYHSGDVRLDTVGSDAYRLSVARALSA
DQGSYRCVVSEWITEQGSWQEIQEKAVEVATVVIQPTALQLAVPRTVSVTEGKDLDLSCN
ITTDRVDDVRPEVTWYFKKTPDTSLLASHMLARLDRDSLVHSSPHVALSHVDTRSYHLLV
RDVSKENSGYYLCLVALWAPGHNRSWHKVAEAMSAPSGVSVTWLEPEYQVYLNASKVPGF
SDDPTELQCRVIDTKRVDAGVRLTVSWYYRMNRRNDDVVASELLAVMDGDWTLRYGERSK
QRAQDGEFIFSKEHTDTFSFRIQRTTEEDRGSYYCVVSAWTRQRNSSWVKSKDVFSKPVN
IFWASEDSVLVVKARQPKPFFAAGNTFEMTCKVSSKNIKSPRYSVLITAEKPVGDLSSPN
ETKYIISLDQDSVVKLENWTDASRVDGVVLEKVQEDEFRYRMYQTQVSDAGLYRCMVTAW
SPIGGSLWREAATSLSNPIEIDFQTSGPIFNASVHSDTLSVTRGDLIKLFCIVTVDGAVL
DPDDMAFDVSWFAVHSFGLDKAPILLSSLDRKGVVTTGQRDWKSTVSLERVSVLEFLLQV
HSSEDQDFGNYYCSVTPWVRSPTGSWQREAEIHSRPIFITVKMDVLNAFKYPLLIGVGLS
TVIGLLSCLIGYCSSHWCCKKEVRETRRERRRLMSMEMD
|
Gene Ontology |
GO:0005783; C:endoplasmic reticulum; IEA:UniProtKB-KW GO:0005794; C:Golgi apparatus; IEA:UniProtKB-KW GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW GO:0017148; P:negative regulation of translation; NAS:UniProtKB |
Interpro |
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Pfam |
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SMART |
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PROSITE |
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PRINTS |
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