Lipid Modification Database
Tag Content
LipidDB ID
LipidDB-10116-00468
Entry Name
UniProt Accession
Theoretical PI
5.02
Molecular Weight
100523.07
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
Sodium/calcium exchanger 2
Protein Synonyms/Alias
Na(+)/Ca(2+)-exchange protein 2; Solute carrier family 8 member 2;
Gene Name
Slc8a2
Gene Synonyms/Alias
Ncx2;
Created Date
01-FEB-1996
 Lipid Modification Sites 
 Position   Sequence Form   Peptide   References   Modification Type 
43
Canonical
SDASPGGCQGSYRCQ
[1]
S-Palmitoylation
151
Canonical
LLSVIEVCGHNFQAG
[1]
S-Palmitoylation
Organism
Rattus norvegicus (Rat)
NCBI Taxa ID
10116
Reference
[1] Predicted from GPS-Lipid
Functional Description
Rapidly transports Ca(2+) during excitation-contraction coupling. Ca(2+) is extruded from the cell during relaxation so as to prevent overloading of intracellular stores.
Sequence Annotation
Topological domain: 21 68 Extracellular.
Transmembrane: 69 90 Helical.
Topological domain: 91 130 Cytoplasmic.
Transmembrane: 131 152 Helical.
Topological domain: 153 164 Extracellular.
Transmembrane: 165 185 Helical.
Topological domain: 186 196 Cytoplasmic.
Transmembrane: 197 219 Helical.
Topological domain: 220 222 Extracellular.
Transmembrane: 223 246 Helical.
Topological domain: 247 720 Cytoplasmic.
Transmembrane: 721 740 Helical.
Topological domain: 741 747 Extracellular.
Transmembrane: 748 770 Helical.
Topological domain: 771 772 Cytoplasmic.
Transmembrane: 773 791 Helical.
Topological domain: 792 822 Extracellular.
Transmembrane: 823 843 Helical.
Topological domain: 844 854 Cytoplasmic.
Transmembrane: 855 875 Helical.
Topological domain: 876 892 Extracellular.
Transmembrane: 893 909 Helical.
Topological domain: 910 921 Cytoplasmic.
Domain: 384 483 Calx-beta 1.
Domain: 512 612 Calx-beta 2.
Region: 248 267 Calmodulin-binding.
Protein Length
921 AA.
Protein Sequence
(Canonical)
MAPLALVGVA LLLGAPHCLG EATPTPSLPP PPANDSDASP GGCQGSYRCQ PGVLLPVWEP  60
DDPSLGDKAA RAVVYFVAMV YMFLGLSIIA DRFMASIEVI TSKEKEITIT KANGETSVGT  120
VRIWNETVSN LTLMALGSSA PEILLSVIEV CGHNFQAGEL GPGTIVGSAA FNMFVVIAVC  180
VYVIPAGESR KIKHLRVFFV TASWSIFAYV WLYLILAVFS PGVVQVWEAL LTLVFFPVCV  240
VFAWMADKRL LFYKYVYKRY RTDPRSGIII GAEGDPPKSI ELDGTFVGTE VPGELGALGT  300
GPAEARELDA SRREVIQILK DLKQKHPDKD LEQLVGIAKY YALLHQQKSR AFYRIQATRL  360
MTGAGNVLRR HAADAARRPG ANDGAPDDED DGASRIFFEP SLYHCLENCG SVLLSVACQG  420
GEGNSTFYVD YRTEDGSAKA GSDYEYSEGT LVFKPGETQK ELRIGIIDDD IFEEDEHFFV  480
RLLNLRVGDA QGMFEPDGGG RPKGRLVAPL LATVTILDDD HAGIFSFQDR LLHVSECMGT  540
VDVRVVRSSG ARGTVRLPYR TVDGTARGGG VHYEDACGEL EFGDDETMKT LQVKIVDDEE  600
YEKKDNFFIE LGQPQWLKRG ISALLLNQGD GDRKLTAEEE EAQRIAEMGK PVLGENCRLE  660
VIIEESYDFK NTVDKLIKKT NLALVIGTHS WREQFLEAVT VSAGDEEEDE DGSREERLPS  720
CFDYVMHFLT VFWKVLFACL PPTEYCHGWA CFGVCILVIG LLTALIGDLA SHFGCTVGLK  780
DSVNAVVFVA LGTSIPDTFA SKVAALQDQC ADASIGNVTG SNAVNVFLGL GVAWSVAAVY  840
WAVQGRPFEV RTGTLAFSVT LFTVFAFVGI AVLLYRRRPH IGGELGGPRG PKLATTALFL  900
GLWFLYILFA SLEAYCHIRG F                                            921
FASTA
(Canonical)
>LipidDB-10116-00468|P48768
MAPLALVGVALLLGAPHCLGEATPTPSLPPPPANDSDASPGGCQGSYRCQPGVLLPVWEP
DDPSLGDKAARAVVYFVAMVYMFLGLSIIADRFMASIEVITSKEKEITITKANGETSVGT
VRIWNETVSNLTLMALGSSAPEILLSVIEVCGHNFQAGELGPGTIVGSAAFNMFVVIAVC
VYVIPAGESRKIKHLRVFFVTASWSIFAYVWLYLILAVFSPGVVQVWEALLTLVFFPVCV
VFAWMADKRLLFYKYVYKRYRTDPRSGIIIGAEGDPPKSIELDGTFVGTEVPGELGALGT
GPAEARELDASRREVIQILKDLKQKHPDKDLEQLVGIAKYYALLHQQKSRAFYRIQATRL
MTGAGNVLRRHAADAARRPGANDGAPDDEDDGASRIFFEPSLYHCLENCGSVLLSVACQG
GEGNSTFYVDYRTEDGSAKAGSDYEYSEGTLVFKPGETQKELRIGIIDDDIFEEDEHFFV
RLLNLRVGDAQGMFEPDGGGRPKGRLVAPLLATVTILDDDHAGIFSFQDRLLHVSECMGT
VDVRVVRSSGARGTVRLPYRTVDGTARGGGVHYEDACGELEFGDDETMKTLQVKIVDDEE
YEKKDNFFIELGQPQWLKRGISALLLNQGDGDRKLTAEEEEAQRIAEMGKPVLGENCRLE
VIIEESYDFKNTVDKLIKKTNLALVIGTHSWREQFLEAVTVSAGDEEEDEDGSREERLPS
CFDYVMHFLTVFWKVLFACLPPTEYCHGWACFGVCILVIGLLTALIGDLASHFGCTVGLK
DSVNAVVFVALGTSIPDTFASKVAALQDQCADASIGNVTGSNAVNVFLGLGVAWSVAAVY
WAVQGRPFEVRTGTLAFSVTLFTVFAFVGIAVLLYRRRPHIGGELGGPRGPKLATTALFL
GLWFLYILFASLEAYCHIRGF
Gene Ontology
GO:0042995; C:cell projection; IDA:RGD
GO:0043197; C:dendritic spine; IDA:RGD
GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW
GO:0005874; C:microtubule; IDA:RGD
GO:0005739; C:mitochondrion; IDA:RGD
GO:0043025; C:neuronal cell body; IDA:RGD
GO:0005886; C:plasma membrane; IDA:RGD
GO:0005432; F:calcium:sodium antiporter activity; IDA:RGD
GO:1990034; P:calcium ion export from cell; IDA:RGD
GO:1990035; P:calcium ion import into cell; IDA:RGD
GO:0060402; P:calcium ion transport into cytosol; IDA:RGD
GO:0007154; P:cell communication; IEA:InterPro
GO:0033280; P:response to vitamin D; IEP:RGD
GO:0035725; P:sodium ion transmembrane transport; IDA:GOC
GO:0006814; P:sodium ion transport; IDA:RGD
GO:0021537; P:telencephalon development; IEP:RGD
Interpro
InterPro; IPR003644; Calx_beta
InterPro; IPR004836; Na_Ca_Ex
InterPro; IPR004837; NaCa_Exmemb
Pfam
Pfam; PF03160; Calx-beta;
Pfam; PF01699; Na_Ca_ex;
SMART
SMART; SM00237; Calx_beta;
PROSITE
PRINTS
PRINTS; PR01259; NACAEXCHNGR;