LipidDB ID

LipidDB-10116-00450

Entry Name

UniProt Accession

P63095; P04894; P08755; Q05087; Q45QM7; Q9Z1R8;

Theoretical PI

5.69

Molecular Weight

45663.6

Genbank Protein ID

AAA41261.1; AAA40827.1; AAA41664.1; AAD11802.1; AAZ23814.1; AAZ23815.1; AAH61967.1;

Genbank Nucleotide ID

M12673; M17525; L10326; AF107844; DQ120475; DQ120476; BC061967;

Protein Name

Guanine nucleotide-binding protein G(s) subunit alpha isoforms short

Protein Synonyms/Alias

Adenylate cyclase-stimulating G alpha protein; G-alpha-8;

Gene Name

Gnas

Gene Synonyms/Alias

Gnas1;

Created Date

13-AUG-1987

Organism

Rattus norvegicus (Rat)

NCBI Taxa ID

10116

Reference

[1] Degtyarev MY, Spiegel AM, Jones TL. The G protein alpha s subunit incorporates[3H]palmitic acid and mutation of cysteine-3 prevents this modification.Biochemistry. 1993 Aug 17;32(32):8057-61.[PMID:8347607]

Functional Description

Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The G(s) protein is involved in hormonal regulation of adenylate cyclase: it activates the cyclase in response to beta-adrenergic stimuli. Stimulates the Ras signaling pathway via RAPGEF2 (By similarity).

Sequence Annotation

Nucleotide-binding: 47 54 GTP.
Nucleotide-binding: 198 204 GTP.
Nucleotide-binding: 223 227 GTP.
Nucleotide-binding: 292 295 GTP.
Metal binding site: 54 54 Magnesium.
Metal binding site: 204 204 Magnesium.
Binding site: 366 366 GTP; via amide nitrogen.
Modified residue: 352 352 Phosphoserine.

Protein Length

394 AA.

Protein Sequence
(Canonical)

FASTA
(Canonical)

Gene Ontology

GO:0005737; C:cytoplasm; IDA:RGD
GO:0005829; C:cytosol; IDA:BHF-UCL
GO:0005768; C:endosome; IDA:RGD
GO:0005834; C:heterotrimeric G-protein complex; IDA:BHF-UCL
GO:0016020; C:membrane; IDA:BHF-UCL
GO:0045121; C:membrane raft; IDA:RGD
GO:0005886; C:plasma membrane; IDA:RGD
GO:0001726; C:ruffle; IDA:RGD
GO:0031982; C:vesicle; IDA:RGD
GO:0043014; F:alpha-tubulin binding; IDA:RGD
GO:0031698; F:beta-2 adrenergic receptor binding; IPI:RGD
GO:0051430; F:corticotropin-releasing hormone receptor 1 binding; IPI:RGD
GO:0031748; F:D1 dopamine receptor binding; IPI:RGD
GO:0001965; F:G-protein alpha-subunit binding; IPI:RGD
GO:0031681; F:G-protein beta-subunit binding; IDA:RGD
GO:0031683; F:G-protein beta/gamma-subunit complex binding; IBA:RefGenome
GO:0005525; F:GTP binding; IDA:RGD
GO:0003924; F:GTPase activity; IBA:RefGenome
GO:0005159; F:insulin-like growth factor receptor binding; IPI:RGD
GO:0035255; F:ionotropic glutamate receptor binding; IPI:RGD
GO:0046872; F:metal ion binding; IEA:UniProtKB-KW
GO:0031852; F:mu-type opioid receptor binding; IDA:RGD
GO:0019904; F:protein domain specific binding; IPI:RGD
GO:0004871; F:signal transducer activity; IDA:RGD
GO:0071880; P:adenylate cyclase-activating adrenergic receptor signaling pathway; ISS:UniProtKB
GO:0007191; P:adenylate cyclase-activating dopamine receptor signaling pathway; IDA:BHF-UCL
GO:0007189; P:adenylate cyclase-activating G-protein coupled receptor signaling pathway; IDA:RGD
GO:0055074; P:calcium ion homeostasis; IMP:RGD
GO:0071870; P:cellular response to catecholamine stimulus; IDA:BHF-UCL
GO:0071380; P:cellular response to prostaglandin E stimulus; IDA:BHF-UCL
GO:0007186; P:G-protein coupled receptor signaling pathway; IMP:RGD
GO:0045776; P:negative regulation of blood pressure; IMP:RGD
GO:0035814; P:negative regulation of renal sodium excretion; IMP:RGD
GO:0030819; P:positive regulation of cAMP biosynthetic process; IMP:RGD
GO:0043950; P:positive regulation of cAMP-mediated signaling; ISS:UniProtKB
GO:0001934; P:positive regulation of protein phosphorylation; IMP:RGD
GO:0032320; P:positive regulation of Ras GTPase activity; ISS:UniProtKB
GO:0010765; P:positive regulation of sodium ion transport; IMP:RGD
GO:0006357; P:regulation of transcription from RNA polymerase II promoter; IMP:RGD
GO:0007606; P:sensory perception of chemical stimulus; IBA:RefGenome

Interpro

InterPro; IPR000367; Gprotein_alpha_S
InterPro; IPR001019; Gprotein_alpha_su
InterPro; IPR011025; GproteinA_insert
InterPro; IPR027417; P-loop_NTPase

Pfam

Pfam; PF00503; G-alpha;

SMART

SMART; SM00275; G_alpha;

PROSITE

PRINTS

PRINTS; PR00318; GPROTEINA;
PRINTS; PR00443; GPROTEINAS;