LipidDB ID

LipidDB-10116-00395

Entry Name

UniProt Accession

P47863;

Theoretical PI

6.65

Molecular Weight

34480.15

Genbank Protein ID

AAC52152.1; AAD37965.1; AAA17730.1;

Genbank Nucleotide ID

U14007; AF144082; L27588;

Protein Name

Aquaporin-4

Protein Synonyms/Alias

AQP-4; Mercurial-insensitive water channel; MIWC; WCH4;

Gene Name

Aqp4

Gene Synonyms/Alias

Created Date

01-FEB-1996

Organism

Rattus norvegicus (Rat)

NCBI Taxa ID

10116

Reference

[1] Suzuki H, Nishikawa K, Hiroaki Y, Fujiyoshi Y. Formation of aquaporin-4 arraysis inhibited by palmitoylation of N-terminal cysteine residues. Biochim BiophysActa. 2008 Apr;1778(4):1181-9. doi: 10.1016/j.bbamem.2007.12.007. Epub 2007 Dec15.[PMID:18179769]

Functional Description

Forms a water-specific channel. Osmoreceptor which regulates body water balance and mediates water flow within the central nervous system. It is expressed predominantly in the ependymal cell lining the aqueductal system and over the space of the brain in contact with the subarachnoid space, as cerebrospinal fluid fills these structures it may facilitate water balance between brain parenchyma and the fluid compartment. In the plasma membranes of the neurons of the paraventricular and supraoptic nuclei, it may mediate rapid changes in cell volume in response to local shifts in extracellular osmolarity.

Sequence Annotation

Topological domain: 1 36 Cytoplasmic.
Transmembrane: 37 57 Helical.
Topological domain: 58 64 Extracellular.
Transmembrane: 65 85 Helical.
Topological domain: 86 115 Cytoplasmic.
Transmembrane: 116 136 Helical.
Topological domain: 137 155 Extracellular.
Transmembrane: 156 176 Helical.
Topological domain: 177 184 Cytoplasmic.
Transmembrane: 185 205 Helical.
Topological domain: 206 231 Extracellular.
Transmembrane: 232 252 Helical.
Topological domain: 253 323 Cytoplasmic.
Motif: 97 99 NPA 1.
Motif: 213 215 NPA 2.
Modified residue: 111 111 Phosphoserine; by PKG.
Modified residue: 180 180 Phosphoserine; by PKC.
Modified residue: 285 285 Phosphoserine.
Modified residue: 321 321 Phosphoserine.

Protein Length

323 AA.

Protein Sequence
(Canonical)

FASTA
(Canonical)

Gene Ontology

GO:0009925; C:basal plasma membrane; IDA:RGD
GO:0016323; C:basolateral plasma membrane; IDA:RGD
GO:0031253; C:cell projection membrane; IDA:RGD
GO:0005911; C:cell-cell junction; IEA:Ensembl
GO:0005737; C:cytoplasm; IEA:Ensembl
GO:0009897; C:external side of plasma membrane; IEA:Ensembl
GO:0005887; C:integral component of plasma membrane; IDA:RGD
GO:0016020; C:membrane; IDA:RGD
GO:0043234; C:protein complex; IDA:RGD
GO:0042383; C:sarcolemma; IDA:RGD
GO:0030315; C:T-tubule; IDA:RGD
GO:0015288; F:porin activity; IDA:RGD
GO:0015250; F:water channel activity; IDA:RGD
GO:0015670; P:carbon dioxide transport; IDA:UniProtKB
GO:0071392; P:cellular response to estradiol stimulus; IEP:RGD
GO:0071333; P:cellular response to glucose stimulus; IMP:RGD
GO:0071346; P:cellular response to interferon-gamma; IEA:Ensembl
GO:0071347; P:cellular response to interleukin-1; IEP:RGD
GO:0071354; P:cellular response to interleukin-6; IEP:RGD
GO:0007565; P:female pregnancy; IEP:RGD
GO:0042538; P:hyperosmotic salinity response; IEP:RGD
GO:0060354; P:negative regulation of cell adhesion molecule production; IMP:RGD
GO:0032691; P:negative regulation of interleukin-1 beta production; IMP:RGD
GO:0032715; P:negative regulation of interleukin-6 production; IMP:RGD
GO:0051260; P:protein homooligomerization; IDA:RGD
GO:0010574; P:regulation of vascular endothelial growth factor production; IMP:RGD
GO:0070295; P:renal water absorption; IEA:Ensembl
GO:0051384; P:response to glucocorticoid; IEP:RGD
GO:0009314; P:response to radiation; IEP:RGD
GO:0007605; P:sensory perception of sound; IEA:Ensembl
GO:0055085; P:transmembrane transport; IDA:GOC
GO:0006833; P:water transport; IDA:RGD

Interpro

InterPro; IPR023271; Aquaporin-like
InterPro; IPR000425; MIP
InterPro; IPR022357; MIP_CS

Pfam

Pfam; PF00230; MIP;

SMART

PROSITE

PROSITE; PS00221; MIP;

PRINTS

PRINTS; PR00783; MINTRINSICP;