LipidDB ID

LipidDB-10116-00384

Entry Name

UniProt Accession

P20171; Q4KLL6; Q5RJJ8;

Theoretical PI

5.16

Molecular Weight

21298.13

Genbank Protein ID

AAA42009.1; AAH86608.1; AAH99130.1; AAA42008.1;

Genbank Nucleotide ID

M13011; BC086608; BC099130; M15188;

Protein Name

GTPase HRas, N-terminally processed

Protein Synonyms/Alias

H-Ras-1; Transforming protein p21; c-H-ras; p21ras;

Gene Name

Hras

Gene Synonyms/Alias

Hras1;

Created Date

01-FEB-1991

Organism

Rattus norvegicus (Rat)

NCBI Taxa ID

10116

Reference

[1] Casey PJ, Solski PA, Der CJ, Buss JE. p21ras is modified by a farnesylisoprenoid. Proc Natl Acad Sci U S A. 1989 Nov;86(21):8323-7.[PMID:2682646]
[2] Clarke S, Vogel JP, Deschenes RJ, Stock J. Posttranslational modification ofthe Ha-ras oncogene protein: evidence for a third class of protein carboxylmethyltransferases. Proc Natl Acad Sci U S A. 1988 Jul;85(13):4643-7. Erratum in:Proc Natl Acad Sci U S A 1988 Oct;85(20):7556.[PMID:3290900]

Functional Description

Ras proteins bind GDP/GTP and possess intrinsic GTPase activity.

Sequence Annotation

Nucleotide-binding: 10 17 GTP.
Nucleotide-binding: 57 61 GTP.
Nucleotide-binding: 116 119 GTP.
Region: 166 185 Hypervariable region.
Motif: 32 40 Effector region.
Modified residue: 1 1 N-acetylmethionine.
Modified residue: 2 2 N-acetylthreonine; in GTPase HRas, N-terminally processed.
Modified residue: 118 118 S-nitrosocysteine.
Modified residue: 186 186 Cysteine methyl ester.

Protein Length

189 AA.

Protein Sequence
(Canonical)

FASTA
(Canonical)

Gene Ontology

GO:0005794; C:Golgi apparatus; ISS:UniProtKB
GO:0043231; C:intracellular membrane-bounded organelle; IDA:RGD
GO:0005886; C:plasma membrane; IDA:UniProtKB
GO:0005525; F:GTP binding; ISS:UniProtKB
GO:0030036; P:actin cytoskeleton organization; IEA:Ensembl
GO:0006915; P:apoptotic process; IMP:RGD
GO:0007050; P:cell cycle arrest; IEA:Ensembl
GO:0008283; P:cell proliferation; IEA:Ensembl
GO:0090398; P:cellular senescence; IEA:Ensembl
GO:0006897; P:endocytosis; IEA:Ensembl
GO:0060441; P:epithelial tube branching involved in lung morphogenesis; IEA:Ensembl
GO:0006184; P:GTP catabolic process; IEA:InterPro
GO:0097193; P:intrinsic apoptotic signaling pathway; IEA:Ensembl
GO:0007093; P:mitotic cell cycle checkpoint; IEA:Ensembl
GO:0045596; P:negative regulation of cell differentiation; IEA:Ensembl
GO:0008285; P:negative regulation of cell proliferation; IEA:Ensembl
GO:0010629; P:negative regulation of gene expression; IEA:Ensembl
GO:0043524; P:negative regulation of neuron apoptotic process; IEA:Ensembl
GO:0034259; P:negative regulation of Rho GTPase activity; IEA:Ensembl
GO:2000251; P:positive regulation of actin cytoskeleton reorganization; IEA:Ensembl
GO:0030335; P:positive regulation of cell migration; IEA:Ensembl
GO:0045740; P:positive regulation of DNA replication; IMP:RGD
GO:0050679; P:positive regulation of epithelial cell proliferation; IEA:Ensembl
GO:0070374; P:positive regulation of ERK1 and ERK2 cascade; IMP:RGD
GO:0046330; P:positive regulation of JNK cascade; IEA:Ensembl
GO:0043406; P:positive regulation of MAP kinase activity; IEA:Ensembl
GO:2000630; P:positive regulation of miRNA metabolic process; IEA:Ensembl
GO:0032855; P:positive regulation of Rac GTPase activity; IEA:Ensembl
GO:0035022; P:positive regulation of Rac protein signal transduction; IEA:Ensembl
GO:0046579; P:positive regulation of Ras protein signal transduction; IMP:MGI
GO:1900029; P:positive regulation of ruffle assembly; IEA:Ensembl
GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IEA:Ensembl
GO:0090303; P:positive regulation of wound healing; IEA:Ensembl
GO:0051291; P:protein heterooligomerization; IPI:RGD
GO:0007265; P:Ras protein signal transduction; IMP:RGD
GO:0048169; P:regulation of long-term neuronal synaptic plasticity; IEA:Ensembl
GO:0032228; P:regulation of synaptic transmission, GABAergic; IEA:Ensembl
GO:0035176; P:social behavior; IEP:RGD
GO:0051146; P:striated muscle cell differentiation; IEA:Ensembl
GO:0008542; P:visual learning; IEA:Ensembl

Interpro

InterPro; IPR027417; P-loop_NTPase
InterPro; IPR005225; Small_GTP-bd_dom
InterPro; IPR001806; Small_GTPase
InterPro; IPR020849; Small_GTPase_Ras

Pfam

Pfam; PF00071; Ras;

SMART

SMART; SM00173; RAS;

PROSITE

PROSITE; PS51421; RAS;

PRINTS

PRINTS; PR00449; RASTRNSFRMNG;