| Tag |
Content |
LipidDB ID |
LipidDB-10116-00373 |
Entry Name |
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UniProt Accession |
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Theoretical PI |
9.06 |
Molecular Weight |
83361.51 |
Genbank Protein ID |
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Genbank Nucleotide ID |
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Protein Name |
Lipid phosphate phosphatase-related protein type 4 |
Protein Synonyms/Alias |
3.1.3.4; Brain-specific phosphatidic acid phosphatase-like protein 1; Plasticity-related gene 1 protein; PRG-1; |
Gene Name |
Lppr4 |
Gene Synonyms/Alias |
Prg1; |
Created Date |
05-FEB-2008 |
| Lipid Modification Sites |
|---|
| Position |
Sequence Form |
Peptide |
References |
Modification Type |
13 | Canonical | SSGARGECDISGTGR | [1] | S-Palmitoylation | 147 | Canonical | VGEGILYCCLSKRRN | [1] | S-Palmitoylation | 148 | Canonical | GEGILYCCLSKRRNG | [1] | S-Palmitoylation | 294 | Canonical | FIICGIICGLTRITQ | [1] | S-Palmitoylation |
|
Organism |
Rattus norvegicus (Rat) |
NCBI Taxa ID |
10116 |
Reference |
[1] Predicted from GPS-Lipid
|
Functional Description |
Hydrolyzes lysophosphatidic acid (LPA). Facilitates axonal outgrowth during development and regenerative sprouting. In the outgrowing axons acts as an ecto-enzyme and attenuates phospholipid-induced axon collapse in neurons and facilitates outgrowth in the hippocampus. |
Sequence Annotation |
Transmembrane: 68 88 Helical.
Transmembrane: 120 140 Helical.
Transmembrane: 179 199 Helical.
Transmembrane: 248 268 Helical.
Transmembrane: 277 297 Helical.
Transmembrane: 309 329 Helical.
|
Protein Length |
766 AA. |
Protein Sequence
(Canonical) |
MQRAGSSGAR GECDISGTGR LRLEQAARLG GRAVHTSPTG GLGARQVAGM SAKERPKGKV 60
IKDSVTLLPC FYFVELPILA SSVVSLYFLE LTDVFKPVHS GFSCYDRSLS MPYIEPTQEA 120
IPFLMLLSLA FAGPAITIMV GEGILYCCLS KRRNGAGLEP NINAGGCNFN SFLRRAVRFV 180
GVHVVGLCST ALITDIIQLA TGYQAPYFLT VCKPMYTSLE GSCKENSYIV EEICSGSDLT 240
VINNGKKSFP SQHATLAAFA AVYVSMYFNS TLTDSSKLLK PLLVFTFIIC GIICGLTRIT 300
QYKNHPVDVY CGFLIGGGIA LYLGLYAVGN FLPSEDSMLQ HRDALRSLTD LNQDPSRVLS 360
AKNGSSGDGI AHTEGILNRN HRDASSLTNL KRANADVEII TPRSPMGKES MVTFSNTLPR 420
ANTPSVEDPV RRNASIHASM DSARSKQLLT QWKSKNESRK MSLQVMDSEP EGQSPPRSIE 480
MRSSSEPSRV GVNGDHHVPG NQYLKIQPGT VPGCNNSMPA GPRVSIQSRP GSSQLVHIPE 540
ETQENISTSP KSSSARAKWL KAAEKTVACN RGNNQPRIMQ VIAMSKQQGV LQSSPKNAEG 600
STVTCTGSIR YKTLTDHEPS GIVRVEAHPE NNRPIIQIPS STEGEGSGSW KWKAPEKSSL 660
RQTYELNDLN RDSESCESLK DSFGSGDRKR KHIDSNEHHH HGITTIRVTP VEGSEIGSET 720
LSVSSSRDST LRRKGNIILI PERSNSPENT RNIFYKGTSP TRPYKD 766
|
FASTA
(Canonical) |
>LipidDB-10116-00373|Q7TMB7
MQRAGSSGARGECDISGTGRLRLEQAARLGGRAVHTSPTGGLGARQVAGMSAKERPKGKV
IKDSVTLLPCFYFVELPILASSVVSLYFLELTDVFKPVHSGFSCYDRSLSMPYIEPTQEA
IPFLMLLSLAFAGPAITIMVGEGILYCCLSKRRNGAGLEPNINAGGCNFNSFLRRAVRFV
GVHVVGLCSTALITDIIQLATGYQAPYFLTVCKPMYTSLEGSCKENSYIVEEICSGSDLT
VINNGKKSFPSQHATLAAFAAVYVSMYFNSTLTDSSKLLKPLLVFTFIICGIICGLTRIT
QYKNHPVDVYCGFLIGGGIALYLGLYAVGNFLPSEDSMLQHRDALRSLTDLNQDPSRVLS
AKNGSSGDGIAHTEGILNRNHRDASSLTNLKRANADVEIITPRSPMGKESMVTFSNTLPR
ANTPSVEDPVRRNASIHASMDSARSKQLLTQWKSKNESRKMSLQVMDSEPEGQSPPRSIE
MRSSSEPSRVGVNGDHHVPGNQYLKIQPGTVPGCNNSMPAGPRVSIQSRPGSSQLVHIPE
ETQENISTSPKSSSARAKWLKAAEKTVACNRGNNQPRIMQVIAMSKQQGVLQSSPKNAEG
STVTCTGSIRYKTLTDHEPSGIVRVEAHPENNRPIIQIPSSTEGEGSGSWKWKAPEKSSL
RQTYELNDLNRDSESCESLKDSFGSGDRKRKHIDSNEHHHHGITTIRVTPVEGSEIGSET
LSVSSSRDSTLRRKGNIILIPERSNSPENTRNIFYKGTSPTRPYKD
|
Gene Ontology |
GO:0009897; C:external side of plasma membrane; IDA:RGD GO:0005887; C:integral component of plasma membrane; IDA:RGD GO:0042577; F:lipid phosphatase activity; IDA:RGD GO:0008195; F:phosphatidate phosphatase activity; IEA:UniProtKB-EC GO:0007409; P:axonogenesis; IDA:RGD GO:0046839; P:phospholipid dephosphorylation; IDA:RGD |
Interpro |
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Pfam |
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SMART |
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PROSITE |
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PRINTS |
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