Lipid Modification Database
Tag Content
LipidDB ID
LipidDB-10116-00369
Entry Name
UniProt Accession
Theoretical PI
5.95
Molecular Weight
56771.82
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
Excitatory amino acid transporter 3
Protein Synonyms/Alias
Excitatory amino-acid carrier 1; Sodium-dependent glutamate/aspartate transporter 3; Solute carrier family 1 member 1;
Gene Name
Slc1a1
Gene Synonyms/Alias
Eaac1; Eaat3;
Created Date
01-OCT-1996
 Lipid Modification Sites 
 Position   Sequence Form   Peptide   References   Modification Type 
158
Canonical
PENLVQACFQQYKTK
[1]
S-Palmitoylation
Organism
Rattus norvegicus (Rat)
NCBI Taxa ID
10116
Reference
[1] Predicted from GPS-Lipid
Functional Description
Transports L-glutamate and also L- and D-aspartate. Essential for terminating the postsynaptic action of glutamate by rapidly removing released glutamate from the synaptic cleft. Acts as a symport by cotransporting sodium. Negatively regulated by ARL6IP5.
Sequence Annotation
Topological domain: 1 18 Cytoplasmic.
Transmembrane: 19 38 Helical.
Transmembrane: 62 82 Helical.
Transmembrane: 94 114 Helical.
Topological domain: 115 208 Extracellular.
Transmembrane: 209 228 Helical.
Transmembrane: 253 272 Helical.
Transmembrane: 289 308 Helical.
Transmembrane: 315 334 Helical.
Transmembrane: 361 380 Helical.
Transmembrane: 391 410 Helical.
Transmembrane: 419 438 Helical.
Protein Length
523 AA.
Protein Sequence
(Canonical)
MGKPTSSGCD WRRFLRNHWL LLSTVAAVVL GIVVGVLVRG HSELSNLDKF YFAFPGEILM  60
RMLKLVILPL IISSMITGVA ALDSNVSGKI GLRAVVYYFS TTVIAVILGI VLVVSIKPGV  120
TQKVNEINRT GKTPEVSTVD AMLDLIRNMF PENLVQACFQ QYKTKREEVK PASDPGGNQT  180
EVSVTTAMTT MSENKTKEYK IVGLYSDGIN VLGLIIFCLV FGLVIGKMGE KGQILVDFFN  240
ALSDATMKIV QIIMCYMPIG ILFLIAGKII EVEDWEIFRK LGLYMATVLS GLAIHSLVVL  300
PLIYFIVVRK NPFRFALGMA QALLTALMIS SSSATLPVTF RCAEEKNHVD KRITRFVLPV  360
GATINMDGTA LYEAVAAVFI AQLNGMDLSI GQIITISITA TAASIGAAGV PQAGLVTMVI  420
VLSAVGLPAE DVTLIIAVDW LLDRFRTMVN VLGDAFGTGI VEKLSKKELE QVDVSSEVNI  480
VNPFALEPTI LDNEDSDTKK SYVNGGFSVD KSDTISFTQT SQF                    523
FASTA
(Canonical)
>LipidDB-10116-00369|P51907
MGKPTSSGCDWRRFLRNHWLLLSTVAAVVLGIVVGVLVRGHSELSNLDKFYFAFPGEILM
RMLKLVILPLIISSMITGVAALDSNVSGKIGLRAVVYYFSTTVIAVILGIVLVVSIKPGV
TQKVNEINRTGKTPEVSTVDAMLDLIRNMFPENLVQACFQQYKTKREEVKPASDPGGNQT
EVSVTTAMTTMSENKTKEYKIVGLYSDGINVLGLIIFCLVFGLVIGKMGEKGQILVDFFN
ALSDATMKIVQIIMCYMPIGILFLIAGKIIEVEDWEIFRKLGLYMATVLSGLAIHSLVVL
PLIYFIVVRKNPFRFALGMAQALLTALMISSSSATLPVTFRCAEEKNHVDKRITRFVLPV
GATINMDGTALYEAVAAVFIAQLNGMDLSIGQIITISITATAASIGAAGVPQAGLVTMVI
VLSAVGLPAEDVTLIIAVDWLLDRFRTMVNVLGDAFGTGIVEKLSKKELEQVDVSSEVNI
VNPFALEPTILDNEDSDTKKSYVNGGFSVDKSDTISFTQTSQF
Gene Ontology
GO:0070062; C:extracellular vesicular exosome; IEA:Ensembl
GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW
GO:0005886; C:plasma membrane; IEA:Ensembl
GO:0016595; F:glutamate binding; IDA:RGD
GO:0015501; F:glutamate:sodium symporter activity; IDA:RGD
GO:0005313; F:L-glutamate transmembrane transporter activity; IDA:RGD
GO:0017153; F:sodium:dicarboxylate symporter activity; IEA:InterPro
GO:0070779; P:D-aspartate import; IEA:Ensembl
GO:0051938; P:L-glutamate import; IEA:Ensembl
GO:0015813; P:L-glutamate transport; IDA:RGD
GO:0051260; P:protein homooligomerization; IDA:RGD
Interpro
InterPro; IPR001991; Na-dicarboxylate_symporter
InterPro; IPR018107; Na-dicarboxylate_symporter_CS
Pfam
Pfam; PF00375; SDF;
SMART
PROSITE
PROSITE; PS00713; NA_DICARBOXYL_SYMP_1;
PROSITE; PS00714; NA_DICARBOXYL_SYMP_2;
PRINTS
PRINTS; PR00173; EDTRNSPORT;