LipidDB ID

LipidDB-10116-00345

Entry Name

UniProt Accession

P59215; P04900; P30033;

Theoretical PI

5.34

Molecular Weight

40068.54

Genbank Protein ID

AAA40826.1; AAA41262.1;

Genbank Nucleotide ID

M17526; M12671;

Protein Name

Guanine nucleotide-binding protein G(o) subunit alpha

Protein Synonyms/Alias

Gene Name

Gnao1

Gene Synonyms/Alias

Gna0; Gnao;

Created Date

13-AUG-1987

Organism

Rattus norvegicus (Rat)

NCBI Taxa ID

10116

Reference

[1] Parenti M, Viganó MA, Newman CM, Milligan G, Magee AI. A novel N-terminalmotif for palmitoylation of G-protein alpha subunits. Biochem J. 1993 Apr 15;291 ( Pt 2):349-53.[PMID:8484716]

Functional Description

Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The G(o) protein function is not clear. Stimulated by RGS14 (By similarity).

Sequence Annotation

Nucleotide-binding: 40 47 GTP.
Nucleotide-binding: 176 182 GTP.
Nucleotide-binding: 201 205 GTP.
Nucleotide-binding: 270 273 GTP.
Metal binding site: 47 47 Magnesium.
Metal binding site: 182 182 Magnesium.
Binding site: 326 326 GTP; via amide nitrogen.
Functional site: 351 351 Not S-palmitoylated.
Modified residue: 346 346 Deamidated asparagine; in form Alpha-3.

Protein Length

354 AA.

Protein Sequence
(Canonical)

FASTA
(Canonical)

Gene Ontology

GO:0005834; C:heterotrimeric G-protein complex; IBA:RefGenome
GO:0016020; C:membrane; IDA:RGD
GO:0043005; C:neuron projection; IDA:RGD
GO:0043234; C:protein complex; IDA:RGD
GO:0051430; F:corticotropin-releasing hormone receptor 1 binding; IPI:RGD
GO:0031683; F:G-protein beta/gamma-subunit complex binding; IBA:RefGenome
GO:0031821; F:G-protein coupled serotonin receptor binding; IPI:RGD
GO:0019003; F:GDP binding; TAS:RGD
GO:0005525; F:GTP binding; IDA:RGD
GO:0032794; F:GTPase activating protein binding; IPI:RGD
GO:0003924; F:GTPase activity; IDA:RGD
GO:0046872; F:metal ion binding; IEA:UniProtKB-KW
GO:0031852; F:mu-type opioid receptor binding; IPI:RGD
GO:0032403; F:protein complex binding; IPI:RGD
GO:0004871; F:signal transducer activity; IBA:RefGenome
GO:0007188; P:adenylate cyclase-modulating G-protein coupled receptor signaling pathway; IBA:RefGenome
GO:0007568; P:aging; IDA:RGD
GO:0007212; P:dopamine receptor signaling pathway; IBA:RefGenome
GO:0030900; P:forebrain development; IEP:RGD
GO:0007186; P:G-protein coupled receptor signaling pathway; IMP:RGD
GO:0007626; P:locomotory behavior; IEA:Ensembl
GO:0051926; P:negative regulation of calcium ion transport; IMP:RGD
GO:0031175; P:neuron projection development; IEP:RGD
GO:0043547; P:positive regulation of GTPase activity; IMP:RGD
GO:0008016; P:regulation of heart contraction; IEA:Ensembl
GO:0034097; P:response to cytokine; IEP:RGD
GO:0042493; P:response to drug; IEP:RGD
GO:0042542; P:response to hydrogen peroxide; IEP:RGD
GO:0043278; P:response to morphine; IEP:RGD
GO:0014070; P:response to organic cyclic compound; IEP:RGD
GO:0010243; P:response to organonitrogen compound; IDA:RGD

Interpro

InterPro; IPR001408; Gprotein_alpha_I
InterPro; IPR001019; Gprotein_alpha_su
InterPro; IPR011025; GproteinA_insert
InterPro; IPR027417; P-loop_NTPase

Pfam

Pfam; PF00503; G-alpha;

SMART

SMART; SM00275; G_alpha;

PROSITE

PRINTS

PRINTS; PR00318; GPROTEINA;
PRINTS; PR00441; GPROTEINAI;