Lipid Modification Database
Tag Content
LipidDB ID
LipidDB-10116-00294
Entry Name
UniProt Accession
Theoretical PI
8.32
Molecular Weight
65962.9
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
G protein-coupled receptor kinase 6
Protein Synonyms/Alias
2.7.11.16; G protein-coupled receptor kinase GRK6;
Gene Name
Grk6
Gene Synonyms/Alias
Gprk6;
Created Date
15-JUL-1998
 Lipid Modification Sites 
 Position   Sequence Form   Peptide   References   Modification Type 
561
Canonical
RLFSRQDCCGNCSDS
[1]
S-Palmitoylation
562
Canonical
LFSRQDCCGNCSDSE
[1]
S-Palmitoylation
565
Canonical
RQDCCGNCSDSEEEL
[1]
S-Palmitoylation
Organism
Rattus norvegicus (Rat)
NCBI Taxa ID
10116
Reference
[1] Takimoto K, Yang EK, Conforti L. Palmitoylation of KChIP splicing variants is required for efficient cell surface expression of Kv4.3 channels. J Biol Chem.2002 Jul 26;277(30):26904-11. Epub 2002 May 10.[PMID:12006572]
Functional Description
Specifically phosphorylates the activated forms of G protein-coupled receptors. Such receptor phosphorylation initiates beta-arrestin-mediated receptor desensitization, internalization, and signaling events leading to their desensitization. Seems to be involved in the desensitization of D2-like dopamine receptors in striatum and chemokine receptor CXCR4 which is critical for CXCL12-induced cell chemotaxis (By similarity). Phosphorylates rhodopsin (RHO) (in vitro) and a non G-protein-coupled receptor: LRP6 during Wnt signaling (in vitro) (By similarity).
Sequence Annotation
Domain: 53 171 RGS.
Domain: 186 448 Protein kinase.
Domain: 449 514 AGC-kinase C-terminal.
Nucleotide-binding: 192 200 ATP.
Nucleotide-binding: 264 270 ATP.
Nucleotide-binding: 315 318 ATP.
Region: 1 185 N-terminal.
Active site: 311 311 Proton acceptor.
Binding site: 215 215 ATP.
Modified residue: 484 484 Phosphoserine; by autocatalysis.
Modified residue: 485 485 Phosphothreonine; by autocatalysis.
Protein Length
576 AA.
Protein Sequence
(Canonical)
MELENIVANT VLLKAREGGG GNRKGKSKKW RQMLQFPHIS QCEELRLSLE RDYHSLCERQ  60
PIGRLLFREF CATRPELTRC TAFLDGVAEY EVTPDEKRKA CGCRLMQNFL SHTGPDLIPE  120
VPRQLVSNCA QRLEQGPCKD LFQELTRLTH EYLSMAPFAD YLDSIYFNRF LQWKWLERQP  180
VTKNTFRQYR VLGKGGFGEV CACQVRATGK MYACKKLEKK RIKKRKGEAM ALNEKQILEK  240
VNSRFVVSLA YAYETKDALC LVLTLMNGGD LKFHIYHMGQ AGFPEARAVF YAAEICCGLE  300
DLHRERIVYR DLKPENILLD DHGHIRISDL GLTVHVPEGQ TIKGRVGTVG YMAPEVVKNE  360
RYTFSPDWWA LGCLLYEMIA GQSPFQQRKK KIKREEVERL VKEVAEEYTD RFSPQARSLC  420
SQLPNKDPAE RLGCRGGGAR EVKEHPLFKK LNFKRLGAGM LEPPFKPDPQ AIYCKDVLDI  480
EQFSTVKGVD LEPTDQDFYQ KFATGSVSIP WQNEMVETEC FQELNVFGLD GSVPPDLDWK  540
GQPTAPPKKG LLQRLFSRQD CCGNCSDSEE ELPTRL                            576
FASTA
(Canonical)
>LipidDB-10116-00294|P97711
MELENIVANTVLLKAREGGGGNRKGKSKKWRQMLQFPHISQCEELRLSLERDYHSLCERQ
PIGRLLFREFCATRPELTRCTAFLDGVAEYEVTPDEKRKACGCRLMQNFLSHTGPDLIPE
VPRQLVSNCAQRLEQGPCKDLFQELTRLTHEYLSMAPFADYLDSIYFNRFLQWKWLERQP
VTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEK
VNSRFVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGLE
DLHRERIVYRDLKPENILLDDHGHIRISDLGLTVHVPEGQTIKGRVGTVGYMAPEVVKNE
RYTFSPDWWALGCLLYEMIAGQSPFQQRKKKIKREEVERLVKEVAEEYTDRFSPQARSLC
SQLPNKDPAERLGCRGGGAREVKEHPLFKKLNFKRLGAGMLEPPFKPDPQAIYCKDVLDI
EQFSTVKGVDLEPTDQDFYQKFATGSVSIPWQNEMVETECFQELNVFGLDGSVPPDLDWK
GQPTAPPKKGLLQRLFSRQDCCGNCSDSEEELPTRL
Gene Ontology
GO:0005829; C:cytosol; IDA:RGD
GO:0005886; C:plasma membrane; IDA:RGD
GO:0005524; F:ATP binding; IEA:UniProtKB-KW
GO:0004703; F:G-protein coupled receptor kinase activity; IDA:RGD
GO:0002029; P:desensitization of G-protein coupled receptor protein signaling pathway; IDA:RGD
GO:0010360; P:negative regulation of anion channel activity; IMP:RGD
GO:0006468; P:protein phosphorylation; IDA:RGD
GO:0038032; P:termination of G-protein coupled receptor signaling pathway; IEA:InterPro
GO:0016055; P:Wnt signaling pathway; IEA:UniProtKB-KW
Interpro
InterPro; IPR000961; AGC-kinase_C
InterPro; IPR000239; GPCR_kinase
InterPro; IPR011009; Kinase-like_dom
InterPro; IPR000719; Prot_kinase_dom
InterPro; IPR017441; Protein_kinase_ATP_BS
InterPro; IPR016137; Regulat_G_prot_signal_superfam
InterPro; IPR000342; RGS_dom
InterPro; IPR002290; Ser/Thr_dual-sp_kinase
InterPro; IPR008271; Ser/Thr_kinase_AS
Pfam
Pfam; PF00069; Pkinase;
Pfam; PF00615; RGS;
SMART
SMART; SM00315; RGS;
SMART; SM00133; S_TK_X;
SMART; SM00220; S_TKc;
PROSITE
PROSITE; PS51285; AGC_KINASE_CTER;
PROSITE; PS00107; PROTEIN_KINASE_ATP;
PROSITE; PS50011; PROTEIN_KINASE_DOM;
PROSITE; PS00108; PROTEIN_KINASE_ST;
PROSITE; PS50132; RGS;
PRINTS
PRINTS; PR00717; GPCRKINASE;