Lipid Modification Database
Tag Content
LipidDB ID
LipidDB-10116-00288
Entry Name
UniProt Accession
Theoretical PI
8.79
Molecular Weight
44930.07
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
B2 bradykinin receptor
Protein Synonyms/Alias
B2R; BK-2 receptor;
Gene Name
Bdkrb2
Gene Synonyms/Alias
Created Date
01-MAY-1992
 Lipid Modification Sites 
 Position   Sequence Form   Peptide   References   Modification Type 
356
Canonical
REVYQAICRKGGCMG
[1]
S-Palmitoylation
Organism
Rattus norvegicus (Rat)
NCBI Taxa ID
10116
Reference
[1] Soskic V, Nyakatura E, Roos M, Müller-Esterl W, Godovac-Zimmermann J.Correlations in palmitoylation and multiple phosphorylation of rat bradykinin B2 receptor in Chinese hamster ovary cells. J Biol Chem. 1999 Mar26;274(13):8539-45.[PMID:10085087]
Functional Description
Receptor for bradykinin. It is associated with G proteins that activate a phosphatidylinositol-calcium second messenger system.
Sequence Annotation
Topological domain: 1 65 Extracellular.
Transmembrane: 66 89 Helical; Name=1.
Topological domain: 90 98 Cytoplasmic.
Transmembrane: 99 123 Helical; Name=2.
Topological domain: 124 136 Extracellular.
Transmembrane: 137 158 Helical; Name=3.
Topological domain: 159 180 Cytoplasmic.
Transmembrane: 181 203 Helical; Name=4.
Topological domain: 204 226 Extracellular.
Transmembrane: 227 253 Helical; Name=5.
Topological domain: 254 272 Cytoplasmic.
Transmembrane: 273 297 Helical; Name=6.
Topological domain: 298 316 Extracellular.
Transmembrane: 317 340 Helical; Name=7.
Topological domain: 341 396 Cytoplasmic.
Modified residue: 161 161 Phosphotyrosine.
Modified residue: 352 352 Phosphotyrosine.
Modified residue: 365 365 Phosphoserine.
Modified residue: 371 371 Phosphoserine.
Modified residue: 374 374 Phosphothreonine.
Modified residue: 378 378 Phosphoserine; by GRK6.
Modified residue: 380 380 Phosphoserine; by GRK6.
Protein Length
396 AA.
Protein Sequence
(Canonical)
MDTRSSLCPK TQAVVAVFWG PGCHLSTCIE MFNITTQALG SAHNGTFSEV NCPDTEWWSW  60
LNAIQAPFLW VLFLLAALEN IFVLSVFCLH KTNCTVAEIY LGNLAAADLI LACGLPFWAI  120
TIANNFDWLF GEVLCRVVNT MIYMNLYSSI CFLMLVSIDR YLALVKTMSM GRMRGVRWAK  180
LYSLVIWSCT LLLSSPMLVF RTMKDYREEG HNVTACVIVY PSRSWEVFTN MLLNLVGFLL  240
PLSIITFCTV RIMQVLRNNE MKKFKEVQTE KKATVLVLAV LGLFVLCWFP FQISTFLDTL  300
LRLGVLSGCW NERAVDIVTQ ISSYVAYSNS CLNPLVYVIV GKRFRKKSRE VYQAICRKGG  360
CMGESVQMEN SMGTLRTSIS VDRQIHKLQD WAGNKQ                            396
FASTA
(Canonical)
>LipidDB-10116-00288|P25023
MDTRSSLCPKTQAVVAVFWGPGCHLSTCIEMFNITTQALGSAHNGTFSEVNCPDTEWWSW
LNAIQAPFLWVLFLLAALENIFVLSVFCLHKTNCTVAEIYLGNLAAADLILACGLPFWAI
TIANNFDWLFGEVLCRVVNTMIYMNLYSSICFLMLVSIDRYLALVKTMSMGRMRGVRWAK
LYSLVIWSCTLLLSSPMLVFRTMKDYREEGHNVTACVIVYPSRSWEVFTNMLLNLVGFLL
PLSIITFCTVRIMQVLRNNEMKKFKEVQTEKKATVLVLAVLGLFVLCWFPFQISTFLDTL
LRLGVLSGCWNERAVDIVTQISSYVAYSNSCLNPLVYVIVGKRFRKKSREVYQAICRKGG
CMGESVQMENSMGTLRTSISVDRQIHKLQDWAGNKQ
Gene Ontology
GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW
GO:0005886; C:plasma membrane; IDA:RGD
GO:0031698; F:beta-2 adrenergic receptor binding; IPI:RGD
GO:0004947; F:bradykinin receptor activity; IDA:RGD
GO:0002438; P:acute inflammatory response to antigenic stimulus; IMP:RGD
GO:0071456; P:cellular response to hypoxia; IEP:RGD
GO:0035633; P:maintenance of blood-brain barrier; IDA:RGD
GO:0045776; P:negative regulation of blood pressure; IMP:RGD
GO:0008285; P:negative regulation of cell proliferation; IMP:RGD
GO:0007204; P:positive regulation of cytosolic calcium ion concentration; IMP:RGD
GO:0042493; P:response to drug; IEP:RGD
GO:0019233; P:sensory perception of pain; TAS:RGD
GO:0006939; P:smooth muscle contraction; IEA:InterPro
GO:0042310; P:vasoconstriction; IEA:InterPro
Interpro
InterPro; IPR001504; Brdyknn_2_rcpt
InterPro; IPR000496; Brdyknn_rcpt
InterPro; IPR000276; GPCR_Rhodpsn
InterPro; IPR017452; GPCR_Rhodpsn_7TM
Pfam
Pfam; PF00001; 7tm_1;
SMART
PROSITE
PROSITE; PS00237; G_PROTEIN_RECEP_F1_1;
PROSITE; PS50262; G_PROTEIN_RECEP_F1_2;
PRINTS
PRINTS; PR00425; BRADYKININR;
PRINTS; PR00994; BRADYKINNB2R;
PRINTS; PR00237; GPCRRHODOPSN;