LipidDB-10116-00170

Lipid Modification Database

Tag

Content

LipidDB ID

LipidDB-10116-00170

Entry Name

VIAAT_RAT

UniProt Accession

O35458;

Theoretical PI

6.19

Molecular Weight

57407.16

Genbank Protein ID

AAB82950.1;

Genbank Nucleotide ID

AF030253;

Protein Name

Vesicular inhibitory amino acid transporter

Protein Synonyms/Alias

GABA and glycine transporter; Solute carrier family 32 member 1; Vesicular GABA transporter; rGVAT;

Gene Name

Slc32a1

Gene Synonyms/Alias

Vgat; Viaat;

Created Date

28-MAR-2003

Lipid Modification Sites
Position	Sequence Form	Peptide	References	Modification Type
285	Canonical	NILVIAYCLSRARDW	[1]	S-Palmitoylation

Organism

Rattus norvegicus (Rat)

NCBI Taxa ID

10116

Reference

[1] Predicted from GPS-Lipid

Functional Description

Involved in the uptake of GABA and glycine into the synaptic vesicles.

Sequence Annotation

Topological domain: 1 133 Cytoplasmic.
Transmembrane: 134 154 Helical.
Topological domain: 155 204 Lumenal, vesicle.
Transmembrane: 205 225 Helical.
Topological domain: 226 242 Cytoplasmic.
Transmembrane: 243 263 Helical.
Topological domain: 264 265 Lumenal, vesicle.
Transmembrane: 266 286 Helical.
Topological domain: 287 305 Cytoplasmic.
Transmembrane: 306 326 Helical.
Topological domain: 327 341 Lumenal, vesicle.
Transmembrane: 342 362 Helical.
Topological domain: 363 383 Cytoplasmic.
Transmembrane: 384 404 Helical.
Topological domain: 405 438 Lumenal, vesicle.
Transmembrane: 439 459 Helical.
Topological domain: 460 461 Cytoplasmic.
Transmembrane: 462 482 Helical.
Topological domain: 483 489 Lumenal, vesicle.
Transmembrane: 490 510 Helical.
Topological domain: 511 525 Cytoplasmic.
Modified residue: 186 186 Nitrated tyrosine.

Protein Length

525 AA.

Protein Sequence
(Canonical)

MATLLRSKLT NVATSVSNKS QAKVSGMFAR MGFQAATDEE AVGFAHCDDL DFEHRQGLQM  60
DILKSEGEPC GDEGAEPPVE GDIHYQRGGA PLPPSGSKDQ AVGAGGEFGG HDKPKITAWE  120
AGWNVTNAIQ GMFVLGLPYA ILHGGYLGLF LIIFAAVVCC YTGKILIACL YEENEDGEVV  180
RVRDSYVAIA NACCAPRFPT LGGRVVNVAQ IIELVMTCIL YVVVSGNLMY NSFPGLPVSQ  240
KSWSIIATAV LLPCAFLKNL KAVSKFSLLC TLAHFVINIL VIAYCLSRAR DWAWEKVKFY  300
IDVKKFPISI GIIVFSYTSQ IFLPSLEGNM QQPSEFHCMM NWTHIAACVL KGLFALVAYL  360
TWADETKEVI TDNLPGSIRA VVNIFLVAKA LLSYPLPFFA AVEVLEKSLF QEGSRAFFPA  420
CYGGDGRLKS WGLTLRCALV VFTLLMAIYV PHFALLMGLT GSLTGAGLCF LLPSLFHLRL  480
LWRKLLWHQV FFDVAIFVIG GICSVSGFVH SLEGLIEAYR TNAED                  525

FASTA
(Canonical)

>LipidDB-10116-00170|O35458
MATLLRSKLTNVATSVSNKSQAKVSGMFARMGFQAATDEEAVGFAHCDDLDFEHRQGLQM
DILKSEGEPCGDEGAEPPVEGDIHYQRGGAPLPPSGSKDQAVGAGGEFGGHDKPKITAWE
AGWNVTNAIQGMFVLGLPYAILHGGYLGLFLIIFAAVVCCYTGKILIACLYEENEDGEVV
RVRDSYVAIANACCAPRFPTLGGRVVNVAQIIELVMTCILYVVVSGNLMYNSFPGLPVSQ
KSWSIIATAVLLPCAFLKNLKAVSKFSLLCTLAHFVINILVIAYCLSRARDWAWEKVKFY
IDVKKFPISIGIIVFSYTSQIFLPSLEGNMQQPSEFHCMMNWTHIAACVLKGLFALVAYL
TWADETKEVITDNLPGSIRAVVNIFLVAKALLSYPLPFFAAVEVLEKSLFQEGSRAFFPA
CYGGDGRLKSWGLTLRCALVVFTLLMAIYVPHFALLMGLTGSLTGAGLCFLLPSLFHLRL
LWRKLLWHQVFFDVAIFVIGGICSVSGFVHSLEGLIEAYRTNAED

Gene Ontology

GO:0051286; C:cell tip; IEA:Ensembl
GO:0044316; C:cone cell pedicle; IEA:Ensembl
GO:0044292; C:dendrite terminus; IEA:Ensembl
GO:0060077; C:inhibitory synapse; IDA:BHF-UCL
GO:0016021; C:integral component of membrane; TAS:RGD
GO:0043229; C:intracellular organelle; IDA:RGD
GO:0045202; C:synapse; IDA:MGI
GO:0008021; C:synaptic vesicle; IDA:RGD
GO:0015495; F:gamma-aminobutyric acid:proton symporter activity; IEA:Ensembl
GO:0015187; F:glycine transmembrane transporter activity; TAS:RGD
GO:0007568; P:aging; IEP:RGD
GO:0015816; P:glycine transport; TAS:RGD
GO:0006836; P:neurotransmitter transport; TAS:RGD

Interpro

InterPro; IPR013057; AA_transpt_TM

Pfam

Pfam; PF01490; Aa_trans;

SMART

PROSITE

PRINTS