Lipid Modification Database
Tag Content
LipidDB ID
LipidDB-10116-00126
Entry Name
UniProt Accession
Theoretical PI
5.14
Molecular Weight
33067.48
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
Syntaxin-1A
Protein Synonyms/Alias
Neuron-specific antigen HPC-1; Synaptotagmin-associated 35 kDa protein; P35A;
Gene Name
Stx1a
Gene Synonyms/Alias
Sap;
Created Date
01-OCT-1993
 Lipid Modification Sites 
 Position   Sequence Form   Peptide   References   Modification Type 
272
Canonical
KIMIIICCVILGIII
[1]
S-Palmitoylation
Organism
Rattus norvegicus (Rat)
NCBI Taxa ID
10116
Reference
[1] Predicted from GPS-Lipid
Functional Description
Potentially involved in docking of synaptic vesicles at presynaptic active zones. May play a critical role in neurotransmitter exocytosis. May mediate Ca(2+)-regulation of exocytosis acrosomal reaction in sperm.
Sequence Annotation
Topological domain: 1 265 Cytoplasmic.
Transmembrane: 266 288 Helical; Anchor for type IV membraneprotein.
Domain: 192 254 t-SNARE coiled-coil homology.
Modified residue: 14 14 Phosphoserine.
Modified residue: 188 188 Phosphoserine; by DAPK1.
Protein Length
288 AA.
Protein Sequence
(Canonical)
MKDRTQELRT AKDSDDDDDV TVTVDRDRFM DEFFEQVEEI RGFIDKIAEN VEEVKRKHSA  60
ILASPNPDEK TKEELEELMS DIKKTANKVR SKLKSIEQSI EQEEGLNRSS ADLRIRKTQH  120
STLSRKFVEV MSEYNATQSD YRERCKGRIQ RQLEITGRTT TSEELEDMLE SGNPAIFASG  180
IIMDSSISKQ ALSEIETRHS EIIKLENSIR ELHDMFMDMA MLVESQGEMI DRIEYNVEHA  240
VDYVERAVSD TKKAVKYQSK ARRKKIMIII CCVILGIIIA STIGGIFG               288
FASTA
(Canonical)
>LipidDB-10116-00126|P32851
MKDRTQELRTAKDSDDDDDVTVTVDRDRFMDEFFEQVEEIRGFIDKIAENVEEVKRKHSA
ILASPNPDEKTKEELEELMSDIKKTANKVRSKLKSIEQSIEQEEGLNRSSADLRIRKTQH
STLSRKFVEVMSEYNATQSDYRERCKGRIQRQLEITGRTTTSEELEDMLESGNPAIFASG
IIMDSSISKQALSEIETRHSEIIKLENSIRELHDMFMDMAMLVESQGEMIDRIEYNVEHA
VDYVERAVSDTKKAVKYQSKARRKKIMIIICCVILGIIIASTIGGIFG
Gene Ontology
GO:0042641; C:actomyosin; IDA:RGD
GO:0030054; C:cell junction; IEA:UniProtKB-KW
GO:0016021; C:integral component of membrane; NAS:UniProtKB
GO:0043229; C:intracellular organelle; IDA:RGD
GO:0043005; C:neuron projection; IEA:UniProtKB-KW
GO:0005886; C:plasma membrane; IDA:RGD
GO:0043234; C:protein complex; IDA:RGD
GO:0030141; C:secretory granule; IDA:UniProtKB
GO:0031201; C:SNARE complex; ISS:UniProtKB
GO:0030672; C:synaptic vesicle membrane; IEA:Ensembl
GO:0070044; C:synaptobrevin 2-SNAP-25-syntaxin-1a complex; IDA:MGI
GO:0070032; C:synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex; IDA:MGI
GO:0070033; C:synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II complex; IDA:RGD
GO:0043008; F:ATP-dependent protein binding; IPI:RGD
GO:0019855; F:calcium channel inhibitor activity; IEA:Ensembl
GO:0048306; F:calcium-dependent protein binding; IPI:RGD
GO:0001948; F:glycoprotein binding; IDA:MGI
GO:0017022; F:myosin binding; IPI:RGD
GO:0032028; F:myosin head/neck binding; IPI:RGD
GO:0030674; F:protein binding, bridging; IPI:RGD
GO:0019904; F:protein domain specific binding; IPI:RGD
GO:0046982; F:protein heterodimerization activity; IDA:RGD
GO:0047485; F:protein N-terminus binding; IDA:RGD
GO:0000149; F:SNARE binding; IDA:MGI
GO:0017156; P:calcium ion-dependent exocytosis; IEA:Ensembl
GO:0006886; P:intracellular protein transport; IEA:InterPro
GO:0006836; P:neurotransmitter transport; TAS:RGD
GO:0045921; P:positive regulation of exocytosis; IDA:RGD
GO:0001956; P:positive regulation of neurotransmitter secretion; IMP:RGD
GO:0017157; P:regulation of exocytosis; IMP:RGD
GO:0009629; P:response to gravity; IDA:RGD
GO:0016081; P:synaptic vesicle docking involved in exocytosis; IEP:UniProtKB
Interpro
InterPro; IPR028669; STX1A/1B
InterPro; IPR006012; Syntaxin/epimorphin_CS
InterPro; IPR006011; Syntaxin_N
InterPro; IPR010989; t-SNARE
InterPro; IPR000727; T_SNARE_dom
Pfam
Pfam; PF05739; SNARE;
Pfam; PF00804; Syntaxin;
SMART
SMART; SM00503; SynN;
SMART; SM00397; t_SNARE;
PROSITE
PROSITE; PS00914; SYNTAXIN;
PROSITE; PS50192; T_SNARE;
PRINTS