Lipid Modification Database
Tag Content
LipidDB ID
LipidDB-10116-00023
Entry Name
UniProt Accession
Theoretical PI
8.99
Molecular Weight
12096.96
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
CDGSH iron-sulfur domain-containing protein 1
Protein Synonyms/Alias
MitoNEET;
Gene Name
Cisd1
Gene Synonyms/Alias
Created Date
25-NOV-2008
 Lipid Modification Sites 
 Position   Sequence Form   Peptide   References   Modification Type 
72
Canonical
LGDKAVYCRCWRSKK
[1]
S-Palmitoylation
Organism
Rattus norvegicus (Rat)
NCBI Taxa ID
10116
Reference
[1] Predicted from GPS-Lipid
Functional Description
Plays a key role in regulating maximal capacity for electron transport and oxidative phosphorylation. May be involved in Fe-S cluster shuttling and/or in redox reactions.
Sequence Annotation
Transmembrane: 13 31 Helical; Signal-anchor for type IIImembrane protein.
Topological domain: 32 108 Cytoplasmic.
Metal binding site: 72 72 Iron-sulfur (2Fe-2S).
Metal binding site: 74 74 Iron-sulfur (2Fe-2S).
Metal binding site: 83 83 Iron-sulfur (2Fe-2S).
Metal binding site: 87 87 Iron-sulfur (2Fe-2S); via pros nitrogen.
Modified residue: 55 55 N6-acetyllysine.
Modified residue: 68 68 N6-acetyllysine.
Modified residue: 104 104 N6-acetyllysine.
Protein Length
108 AA.
Protein Sequence
(Canonical)
MGLSSDSPVR VEWIAAVTFA AGTAALGYLA YKKFYAKESR TKAMVNLQIQ KDNPKVVHAF  60
DMEDLGDKAV YCRCWRSKKF PFCDGAHIKH NEETGDNVGP LIIKKKET               108
FASTA
(Canonical)
>LipidDB-10116-00023|B0K020
MGLSSDSPVRVEWIAAVTFAAGTAALGYLAYKKFYAKESRTKAMVNLQIQKDNPKVVHAF
DMEDLGDKAVYCRCWRSKKFPFCDGAHIKHNEETGDNVGPLIIKKKET
Gene Ontology
GO:0070062; C:extracellular vesicular exosome; IEA:Ensembl
GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW
GO:0005741; C:mitochondrial outer membrane; IEA:UniProtKB-KW
GO:0051537; F:2 iron, 2 sulfur cluster binding; IEA:UniProtKB-KW
GO:0046872; F:metal ion binding; IEA:UniProtKB-KW
GO:0043457; P:regulation of cellular respiration; IEA:Ensembl
Interpro
InterPro; IPR018967; FeS-contain_CDGSH-typ
InterPro; IPR006622; FeS-contain_CDGSH-typ_subfam
InterPro; IPR019610; FeS-contain_mitoNEET_N
Pfam
Pfam; PF10660; MitoNEET_N;
Pfam; PF09360; zf-CDGSH;
SMART
SMART; SM00704; ZnF_CDGSH;
PROSITE
PRINTS