LipidDB-10090-01461

Lipid Modification Database

Tag

Content

LipidDB ID

LipidDB-10090-01461

Entry Name

RRAS2_MOUSE

UniProt Accession

P62071; P17082; Q3TA79; Q8C5D1; Q9D0H6;

Theoretical PI

5.74

Molecular Weight

23399.57

Genbank Protein ID

BAB27607.1; BAC37432.1; BAE42790.1; AAH03871.1;

Genbank Nucleotide ID

AK011419; AK078870; AK172037; BC003871;

Protein Name

Ras-related protein R-Ras2

Protein Synonyms/Alias

Gene Name

Rras2

Gene Synonyms/Alias

Created Date

21-JUN-2004

Lipid Modification Sites
Position	Sequence Form	Peptide	References	Modification Type
199	Canonical	KEKDKKGCHCVIF**	[1]	S-Palmitoylation

Organism

Mus musculus (Mouse)

NCBI Taxa ID

10090

Reference

[1] Predicted from GPS-Lipid

Functional Description

It is a plasma membrane-associated GTP-binding protein with GTPase activity. Might transduce growth inhibitory signals across the cell membrane, exerting its effect through an effector shared with the Ras proteins but in an antagonistic fashion.

Sequence Annotation

Nucleotide-binding: 21 29 GTP.
Nucleotide-binding: 68 72 GTP.
Nucleotide-binding: 127 130 GTP.
Nucleotide-binding: 157 159 GTP.
Motif: 43 51 Effector region.
Modified residue: 2 2 N-acetylalanine.
Modified residue: 186 186 Phosphoserine.
Modified residue: 201 201 Cysteine methyl ester.

Protein Length

204 AA.

Protein Sequence
(Canonical)

MAAAGWRDGS GQEKYRLVVV GGGGVGKSAL TIQFIQSYFV TDYDPTIEDS YTKQCVIDDR  60
AARLDILDTA GQEEFGAMRE QYMRTGEGFL LVFSVTDRGS FEEIYKFQRQ ILRVKDRDEF  120
PMILIGNKAD LDHQRQVTQE EGQQLARQLK VTYMEASAKI RMNVDQAFHE LVRVIRKFQE  180
QECPPSPEPT RKEKDKKGCH CVIF                                         204

FASTA
(Canonical)

>LipidDB-10090-01461|P62071
MAAAGWRDGSGQEKYRLVVVGGGGVGKSALTIQFIQSYFVTDYDPTIEDSYTKQCVIDDR
AARLDILDTAGQEEFGAMREQYMRTGEGFLLVFSVTDRGSFEEIYKFQRQILRVKDRDEF
PMILIGNKADLDHQRQVTQEEGQQLARQLKVTYMEASAKIRMNVDQAFHELVRVIRKFQE
QECPPSPEPTRKEKDKKGCHCVIF

Gene Ontology

GO:0070062; C:extracellular vesicular exosome; IEA:Ensembl
GO:0005622; C:intracellular; IDA:MGI
GO:0005886; C:plasma membrane; IEA:UniProtKB-KW
GO:0005525; F:GTP binding; IEA:UniProtKB-KW
GO:0009987; P:cellular process; IDA:MGI
GO:0006184; P:GTP catabolic process; IEA:InterPro
GO:0001649; P:osteoblast differentiation; IEA:Ensembl
GO:0030335; P:positive regulation of cell migration; IGI:MGI
GO:0007265; P:Ras protein signal transduction; IDA:MGI

Interpro

InterPro; IPR027417; P-loop_NTPase
InterPro; IPR005225; Small_GTP-bd_dom
InterPro; IPR001806; Small_GTPase
InterPro; IPR020849; Small_GTPase_Ras

Pfam

Pfam; PF00071; Ras;

SMART

SMART; SM00173; RAS;

PROSITE

PROSITE; PS51421; RAS;

PRINTS

PRINTS; PR00449; RASTRNSFRMNG;