LipidDB ID

LipidDB-10090-01455

Entry Name

UniProt Accession

Q60898; Q8C9Q8; Q8CAT0; Q8CBE9; Q8QZX8;

Theoretical PI

8.14

Molecular Weight

31680.81

Genbank Protein ID

AAA82756.1; CAB66139.1; AAL87537.1; AAL87538.1; BAC29328.1; BAC29896.1; BAC30988.1; AAH32922.1;

Genbank Nucleotide ID

U29056; AJ131777; AY079449; AY079450; AK036167; AK037901; AK041565; BC032922;

Protein Name

Src-like-adapter

Protein Synonyms/Alias

Src-like-adapter protein 1; SLAP-1; mSLAP;

Gene Name

Sla

Gene Synonyms/Alias

Slap; Slap1;

Created Date

23-APR-2003

Organism

Mus musculus (Mouse)

NCBI Taxa ID

10090

Reference

[1] Manes G, Bello P, Roche S. Slap negatively regulates Src mitogenic functionbut does not revert Src-induced cell morphology changes. Mol Cell Biol. 2000May;20(10):3396-406.[PMID:10779329]

Functional Description

Adapter protein, which negatively regulates T-cell receptor (TCR) signaling. Inhibits T-cell antigen-receptor induced activation of nuclear factor of activated T-cells. Involved in the negative regulation of positive selection and mitosis of T-cells. May act by linking signaling proteins such as ZAP70 with CBL, leading to a CBL dependent degradation of signaling proteins.

Sequence Annotation

Domain: 22 82 SH3.
Domain: 84 175 SH2.
Region: 190 281 SLA C-terminal.
Modified residue: 278 278 Phosphotyrosine.

Protein Length

281 AA.

Protein Sequence
(Canonical)

FASTA
(Canonical)

Gene Ontology

GO:0005768; C:endosome; IEA:UniProtKB-KW

Interpro

InterPro; IPR000980; SH2
InterPro; IPR001452; SH3_domain

Pfam

Pfam; PF00017; SH2;
Pfam; PF00018; SH3_1;

SMART

SMART; SM00252; SH2;
SMART; SM00326; SH3;

PROSITE

PROSITE; PS50001; SH2;
PROSITE; PS50002; SH3;

PRINTS

PRINTS; PR00401; SH2DOMAIN;