Lipid Modification Database
Tag Content
LipidDB ID
LipidDB-10090-01451
Entry Name
UniProt Accession
Theoretical PI
5.75
Molecular Weight
78492.0
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
Nicastrin
Protein Synonyms/Alias
Gene Name
Ncstn
Gene Synonyms/Alias
Created Date
11-JAN-2001
 Lipid Modification Sites 
 Position   Sequence Form   Peptide   References   Modification Type 
688
Canonical
FSLIVTYCINAKADV
[1]
S-Palmitoylation
Organism
Mus musculus (Mouse)
NCBI Taxa ID
10090
Reference
[1] Predicted from GPS-Lipid
Functional Description
Essential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (beta- amyloid precursor protein). It probably represents a stabilizing cofactor required for the assembly of the gamma-secretase complex.
Sequence Annotation
Topological domain: 28 668 Extracellular.
Transmembrane: 669 689 Helical.
Topological domain: 690 708 Cytoplasmic.
Protein Length
708 AA.
Protein Sequence
(Canonical)
MATTRGGSGP DPGSRGLLLL SFSVVLAGLC GGNSVERKIY IPLNKTAPCV RLLNATHQIG  60
CQSSISGDTG VIHVVEKEED LKWVLTDGPN PPYMVLLEGK LFTRDVMEKL KGTTSRIAGL  120
AVTLAKPNST SSFSPSVQCP NDGFGIYSNS YGPEFAHCKK TLWNELGNGL AYEDFSFPIF  180
LLEDENETKV IKQCYQDHNL GQNGSAPSFP LCAMQLFSHM HAVISTATCM RRSFIQSTFS  240
INPEIVCDPL SDYNVWSMLK PINTSVGLEP DVRVVVAATR LDSRSFFWNV APGAESAVAS  300
FVTQLAAAEA LHKAPDVTTL SRNVMFVFFQ GETFDYIGSS RMVYDMENGK FPVRLENIDS  360
FVELGQVALR TSLDLWMHTD PMSQKNESVK NQVEDLLATL EKSGAGVPEV VLRRLAQSQA  420
LPPSSLQRFL RARNISGVVL ADHSGSFHNR YYQSIYDTAE NINVTYPEWQ SPEEDLNFVT  480
DTAKALANVA TVLARALYEL AGGTNFSSSI QADPQTVTRL LYGFLVRANN SWFQSILKHD  540
LRSYLDDRPL QHYIAVSSPT NTTYVVQYAL ANLTGKATNL TREQCQDPSK VPNESKDLYE  600
YSWVQGPWNS NRTERLPQCV RSTVRLARAL SPAFELSQWS STEYSTWAES RWKDIQARIF  660
LIASKELEFI TLIVGFSTLV FSLIVTYCIN AKADVLFVAP REPGAVSY               708
FASTA
(Canonical)
>LipidDB-10090-01451|P57716
MATTRGGSGPDPGSRGLLLLSFSVVLAGLCGGNSVERKIYIPLNKTAPCVRLLNATHQIG
CQSSISGDTGVIHVVEKEEDLKWVLTDGPNPPYMVLLEGKLFTRDVMEKLKGTTSRIAGL
AVTLAKPNSTSSFSPSVQCPNDGFGIYSNSYGPEFAHCKKTLWNELGNGLAYEDFSFPIF
LLEDENETKVIKQCYQDHNLGQNGSAPSFPLCAMQLFSHMHAVISTATCMRRSFIQSTFS
INPEIVCDPLSDYNVWSMLKPINTSVGLEPDVRVVVAATRLDSRSFFWNVAPGAESAVAS
FVTQLAAAEALHKAPDVTTLSRNVMFVFFQGETFDYIGSSRMVYDMENGKFPVRLENIDS
FVELGQVALRTSLDLWMHTDPMSQKNESVKNQVEDLLATLEKSGAGVPEVVLRRLAQSQA
LPPSSLQRFLRARNISGVVLADHSGSFHNRYYQSIYDTAENINVTYPEWQSPEEDLNFVT
DTAKALANVATVLARALYELAGGTNFSSSIQADPQTVTRLLYGFLVRANNSWFQSILKHD
LRSYLDDRPLQHYIAVSSPTNTTYVVQYALANLTGKATNLTREQCQDPSKVPNESKDLYE
YSWVQGPWNSNRTERLPQCVRSTVRLARALSPAFELSQWSSTEYSTWAESRWKDIQARIF
LIASKELEFITLIVGFSTLVFSLIVTYCINAKADVLFVAPREPGAVSY
Gene Ontology
GO:0005783; C:endoplasmic reticulum; ISS:UniProtKB
GO:0070062; C:extracellular vesicular exosome; IEA:Ensembl
GO:0005794; C:Golgi apparatus; ISS:UniProtKB
GO:0005887; C:integral component of plasma membrane; ISS:UniProtKB
GO:0005765; C:lysosomal membrane; IEA:Ensembl
GO:0016020; C:membrane; IDA:MGI
GO:0005886; C:plasma membrane; IDA:MGI
GO:0004175; F:endopeptidase activity; IMP:MGI
GO:0050435; P:beta-amyloid metabolic process; IMP:MGI
GO:0050673; P:epithelial cell proliferation; IMP:MGI
GO:0006509; P:membrane protein ectodomain proteolysis; ISS:UniProtKB
GO:0002262; P:myeloid cell homeostasis; IMP:MGI
GO:0007219; P:Notch signaling pathway; IEA:UniProtKB-KW
GO:0043085; P:positive regulation of catalytic activity; ISS:UniProtKB
GO:0016485; P:protein processing; ISS:UniProtKB
GO:0042098; P:T cell proliferation; IMP:MGI
Interpro
InterPro; IPR008710; Nicastrin
Pfam
Pfam; PF05450; Nicastrin;
SMART
PROSITE
PRINTS