Lipid Modification Database
Tag Content
LipidDB ID
LipidDB-10090-01441
Entry Name
UniProt Accession
Theoretical PI
6.65
Molecular Weight
122158.76
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
Integrin alpha-6 light chain
Protein Synonyms/Alias
CD49 antigen-like family member F; VLA-6; CD49f;
Gene Name
Itga6
Gene Synonyms/Alias
Created Date
15-JUL-1998
 Lipid Modification Sites 
 Position   Sequence Form   Peptide   References   Modification Type 
8
Canonical
MAVAGQLCLLYLSAG
[1]
S-Palmitoylation
562
Canonical
NRQKQRACMEETLWL
[1]
S-Palmitoylation
1039
Canonical
LVFLLWKCGFFKRSR
[1]
S-Palmitoylation
Organism
Mus musculus (Mouse)
NCBI Taxa ID
10090
Reference
[1] Predicted from GPS-Lipid
Functional Description
Integrin alpha-6/beta-1 is a receptor for laminin on platelets. Integrin alpha-6/beta-4 is a receptor for laminin in epithelial cells and it plays a critical structural role in the hemidesmosome. Mice expressing a null mutation of the alpha-6 subunit gene die soon after birth and develop severe blistering. The blisters are due to separation of the basal epithelial cells from a normally formed basement membrane.
Sequence Annotation
Topological domain: 24 1011 Extracellular.
Transmembrane: 1012 1037 Helical.
Topological domain: 1038 1091 Cytoplasmic.
Motif: 1040 1044 GFFKR motif.
Protein Length
1091 AA.
Protein Sequence
(Canonical)
MAVAGQLCLL YLSAGLLARL GTAFNLDTRE DNVIRKSGDP GSLFGFSLAM HWQLQPEDKR  60
LLLVGAPRAE ALPLQRANRT GGLYSCDITS RGPCTRIEFD NDADPMSESK EDQWMGVTVQ  120
SQGPGGKVVT CAHRYEKRQH VNTKQESRDI FGRCYVLSQN LRIEDDMDGG DWSFCDGRLR  180
GHEKFGSCQQ GVAATFTKDF HYIVFGAPGT YNWKGIVRVE QKNNTFFDMN IFEDGPYEVG  240
GETDHDESLV PVPANSYLGF SLDSGKGIVS KDDITFVSGA PRANHSGAVV LLKRDMKSAH  300
LLPEYIFDGE GLASSFGYDV AVVDLNADGW QDIVIGAPQY FDRDGEVGGA VYVYINQQGK  360
WSNVKPIRLN GTKDSMFGIS VKNIGDINQD GYPDIAVGAP YDDLGKVFIY HGSPTGIITK  420
PTQVLEGTSP YFGYSIAGNM DLDRNSYPDL AVGSLSDSVT IFRSRPVINI LKTITVTPNR  480
IDLRQKSMCG SPSGICLKVK ACFEYTAKPS GYNPPISILG ILEAEKERRK SGLSSRVQFR  540
NQGSEPKYTQ ELTLNRQKQR ACMEETLWLQ ENIRDKLRPI PITASVEIQE PSSRRRVNSL  600
PEVLPILNSN EAKTVQTDVH FLKEGCGDDN VCNSNLKLEY KFGTREGNQD KFSYLPIQKG  660
IPELVLKDQK DIALEITVTN SPSDPRNPRK DGDDAHEAKL IATFPDTLTY SAYRELRAFP  720
EKQLSCVANQ NGSQADCELG NPFKRNSSVT FYLILSTTEV TFDTTDLDIN LKLETTSNQD  780
NLAPITAKAK VVIELLLSVS GVAKPSQVYF GGTVVGEQAM KSEDEVGSLI EYEFRVINLG  840
KPLKNLGTAT LNIQWPKEIS NGKWLLYLMK VESKGLEQIV CEPHNEINYL KLKESHNSRK  900
KRELPEKQID DSRKFSLFPE RKYQTLNCSV NVRCVNIRCP LRGLDSKASL VLRSRLWNST  960
FLEEYSKLNY LDILLRASID VTAAAQNIKL PHAGTQVRVT VFPSKTVAQY SGVAWWIILL  1020
AVLAGILMLA LLVFLLWKCG FFKRSRYDDS IPRYHAVRIR KEEREIKDEK HMDNLEKKQW  1080
ITKWNENESY S                                                       1091
FASTA
(Canonical)
>LipidDB-10090-01441|Q61739
MAVAGQLCLLYLSAGLLARLGTAFNLDTREDNVIRKSGDPGSLFGFSLAMHWQLQPEDKR
LLLVGAPRAEALPLQRANRTGGLYSCDITSRGPCTRIEFDNDADPMSESKEDQWMGVTVQ
SQGPGGKVVTCAHRYEKRQHVNTKQESRDIFGRCYVLSQNLRIEDDMDGGDWSFCDGRLR
GHEKFGSCQQGVAATFTKDFHYIVFGAPGTYNWKGIVRVEQKNNTFFDMNIFEDGPYEVG
GETDHDESLVPVPANSYLGFSLDSGKGIVSKDDITFVSGAPRANHSGAVVLLKRDMKSAH
LLPEYIFDGEGLASSFGYDVAVVDLNADGWQDIVIGAPQYFDRDGEVGGAVYVYINQQGK
WSNVKPIRLNGTKDSMFGISVKNIGDINQDGYPDIAVGAPYDDLGKVFIYHGSPTGIITK
PTQVLEGTSPYFGYSIAGNMDLDRNSYPDLAVGSLSDSVTIFRSRPVINILKTITVTPNR
IDLRQKSMCGSPSGICLKVKACFEYTAKPSGYNPPISILGILEAEKERRKSGLSSRVQFR
NQGSEPKYTQELTLNRQKQRACMEETLWLQENIRDKLRPIPITASVEIQEPSSRRRVNSL
PEVLPILNSNEAKTVQTDVHFLKEGCGDDNVCNSNLKLEYKFGTREGNQDKFSYLPIQKG
IPELVLKDQKDIALEITVTNSPSDPRNPRKDGDDAHEAKLIATFPDTLTYSAYRELRAFP
EKQLSCVANQNGSQADCELGNPFKRNSSVTFYLILSTTEVTFDTTDLDINLKLETTSNQD
NLAPITAKAKVVIELLLSVSGVAKPSQVYFGGTVVGEQAMKSEDEVGSLIEYEFRVINLG
KPLKNLGTATLNIQWPKEISNGKWLLYLMKVESKGLEQIVCEPHNEINYLKLKESHNSRK
KRELPEKQIDDSRKFSLFPERKYQTLNCSVNVRCVNIRCPLRGLDSKASLVLRSRLWNST
FLEEYSKLNYLDILLRASIDVTAAAQNIKLPHAGTQVRVTVFPSKTVAQYSGVAWWIILL
AVLAGILMLALLVFLLWKCGFFKRSRYDDSIPRYHAVRIRKEEREIKDEKHMDNLEKKQW
ITKWNENESYS
Gene Ontology
GO:0045178; C:basal part of cell; IDA:MGI
GO:0009925; C:basal plasma membrane; IDA:MGI
GO:0005604; C:basement membrane; IDA:MGI
GO:0016323; C:basolateral plasma membrane; IDA:MGI
GO:0009986; C:cell surface; IDA:MGI
GO:0005913; C:cell-cell adherens junction; IEA:Ensembl
GO:0009897; C:external side of plasma membrane; IDA:MGI
GO:0030175; C:filopodium; IEA:Ensembl
GO:0030056; C:hemidesmosome; IDA:MGI
GO:0034676; C:integrin alpha6-beta4 complex; IEA:Ensembl
GO:0008305; C:integrin complex; IDA:MGI
GO:0005886; C:plasma membrane; IDA:MGI
GO:0005178; F:integrin binding; IPI:MGI
GO:0046872; F:metal ion binding; IEA:UniProtKB-KW
GO:0050873; P:brown fat cell differentiation; IDA:MGI
GO:0033627; P:cell adhesion mediated by integrin; IDA:MGI
GO:0007160; P:cell-matrix adhesion; IMP:MGI
GO:0031668; P:cellular response to extracellular stimulus; IDA:MGI
GO:0071407; P:cellular response to organic cyclic compound; IEA:Ensembl
GO:0046847; P:filopodium assembly; IMP:MGI
GO:0007229; P:integrin-mediated signaling pathway; IEA:UniProtKB-KW
GO:0050900; P:leukocyte migration; IMP:MGI
GO:2001237; P:negative regulation of extrinsic apoptotic signaling pathway; IEA:Ensembl
GO:0042475; P:odontogenesis of dentin-containing tooth; IMP:MGI
GO:0043065; P:positive regulation of apoptotic process; IEA:Ensembl
GO:0022409; P:positive regulation of cell-cell adhesion; IDA:MGI
GO:0010811; P:positive regulation of cell-substrate adhesion; IEA:Ensembl
GO:0042327; P:positive regulation of phosphorylation; IEA:Ensembl
GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IEA:Ensembl
GO:0016337; P:single organismal cell-cell adhesion; IEA:Ensembl
Interpro
InterPro; IPR013519; Int_alpha_beta-p
InterPro; IPR000413; Integrin_alpha
InterPro; IPR013649; Integrin_alpha-2
InterPro; IPR018184; Integrin_alpha_C_CS
Pfam
Pfam; PF08441; Integrin_alpha2;
SMART
SMART; SM00191; Int_alpha;
PROSITE
PROSITE; PS51470; FG_GAP;
PROSITE; PS00242; INTEGRIN_ALPHA;
PRINTS
PRINTS; PR01185; INTEGRINA;