| Tag |
Content |
LipidDB ID |
LipidDB-10090-01438 |
Entry Name |
|
UniProt Accession |
|
Theoretical PI |
8.04 |
Molecular Weight |
55503.38 |
Genbank Protein ID |
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Genbank Nucleotide ID |
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Protein Name |
Sodium-coupled neutral amino acid transporter 2 |
Protein Synonyms/Alias |
Amino acid transporter A2; Solute carrier family 38 member 2; System A amino acid transporter 2; System A transporter 1; System N amino acid transporter 2; |
Gene Name |
Slc38a2 |
Gene Synonyms/Alias |
Ata2; Kiaa1382; Sat2; Snat2; |
Created Date |
13-NOV-2007 |
| Lipid Modification Sites |
|---|
| Position |
Sequence Form |
Peptide |
References |
Modification Type |
238 | Canonical | FFLIVVICKKFQIPC | [1] | S-Palmitoylation |
|
Organism |
Mus musculus (Mouse) |
NCBI Taxa ID |
10090 |
Reference |
[1] Predicted from GPS-Lipid
|
Functional Description |
Functions as a sodium-dependent amino acid transporter. Mediates the saturable, pH-sensitive and electrogenic cotransport of neutral amino acids and sodium ions with a stoichiometry of 1:1. May function in the transport of amino acids at the blood- brain barrier and in the supply of maternal nutrients to the fetus through the placenta. |
Sequence Annotation |
Topological domain: 1 76 Cytoplasmic.
Transmembrane: 77 97 Helical.
Topological domain: 98 102 Extracellular.
Transmembrane: 103 123 Helical.
Topological domain: 124 158 Cytoplasmic.
Transmembrane: 159 179 Helical.
Topological domain: 180 188 Extracellular.
Transmembrane: 189 209 Helical.
Topological domain: 210 217 Cytoplasmic.
Transmembrane: 218 238 Helical.
Topological domain: 239 289 Extracellular.
Transmembrane: 290 310 Helical.
Topological domain: 311 326 Cytoplasmic.
Transmembrane: 327 347 Helical.
Topological domain: 348 368 Extracellular.
Transmembrane: 369 389 Helical.
Topological domain: 390 410 Cytoplasmic.
Transmembrane: 411 431 Helical.
Topological domain: 432 433 Extracellular.
Transmembrane: 434 454 Helical.
Topological domain: 455 471 Cytoplasmic.
Transmembrane: 472 492 Helical.
Topological domain: 493 504 Extracellular.
Region: 1 96 Regulates protein turnover upon aminoacid deprivation.
Modified residue: 12 12 Phosphoserine.
Modified residue: 22 22 Phosphoserine.
Modified residue: 55 55 Phosphoserine.
|
Protein Length |
504 AA. |
Protein Sequence
(Canonical) |
MKKTEMGRFN ISPDEDSSSY SSNSDFNYSY PTKQAALKSH YADVDPENQN FLLESNLGKK 60
KYETDFHPGT TSFGMSVFNL SNAIVGSGIL GLSYAMANTG IALFIILLTF VSIFSLYSVH 120
LLLKTANEGG SLLYEQLGHK AYGLAGKLAA SGSITMQNIG AMSSYLFIVK YELPLVIKAL 180
MNIEDTNGLW YLNGDYLVLL VSLVLILPLS LLRNLGYLGY TSGLSLLCMI FFLIVVICKK 240
FQIPCPVEAA LVANETVNGT FTQAALALAF NSTADDACRP RYFIFNSQTV YAVPILTFSF 300
VCHPAVLPIY EELKSRSRRR MMNVSKISFF AMFLMYLLAA LFGYLTFYGH VESELLHTYS 360
EIVGTDILLL VVRLAVLVAV TLTVPVVIFP IRSSVTHLLC PTKEFSWLRH SIITVTILSF 420
TNLLVIFVPT IRDIFGFIGA SAAAMLIFIL PSAFYIKLVK KEPMRSVQKI GALCFLLSGI 480
VVMIGSMGLI VLDWVHDASA AGGH 504
|
FASTA
(Canonical) |
>LipidDB-10090-01438|Q8CFE6
MKKTEMGRFNISPDEDSSSYSSNSDFNYSYPTKQAALKSHYADVDPENQNFLLESNLGKK
KYETDFHPGTTSFGMSVFNLSNAIVGSGILGLSYAMANTGIALFIILLTFVSIFSLYSVH
LLLKTANEGGSLLYEQLGHKAYGLAGKLAASGSITMQNIGAMSSYLFIVKYELPLVIKAL
MNIEDTNGLWYLNGDYLVLLVSLVLILPLSLLRNLGYLGYTSGLSLLCMIFFLIVVICKK
FQIPCPVEAALVANETVNGTFTQAALALAFNSTADDACRPRYFIFNSQTVYAVPILTFSF
VCHPAVLPIYEELKSRSRRRMMNVSKISFFAMFLMYLLAALFGYLTFYGHVESELLHTYS
EIVGTDILLLVVRLAVLVAVTLTVPVVIFPIRSSVTHLLCPTKEFSWLRHSIITVTILSF
TNLLVIFVPTIRDIFGFIGASAAAMLIFILPSAFYIKLVKKEPMRSVQKIGALCFLLSGI
VVMIGSMGLIVLDWVHDASAAGGH
|
Gene Ontology |
GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW GO:0005886; C:plasma membrane; IDA:MGI GO:0015171; F:amino acid transmembrane transporter activity; IDA:MGI GO:0015293; F:symporter activity; IEA:UniProtKB-KW GO:0003333; P:amino acid transmembrane transport; IDA:GOC GO:0006865; P:amino acid transport; IDA:MGI GO:0006814; P:sodium ion transport; IEA:UniProtKB-KW |
Interpro |
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Pfam |
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SMART |
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PROSITE |
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PRINTS |
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