Lipid Modification Database
Tag Content
LipidDB ID
LipidDB-10090-01415
Entry Name
UniProt Accession
Theoretical PI
5.69
Molecular Weight
66579.95
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
Potassium voltage-gated channel subfamily A member 5
Protein Synonyms/Alias
Voltage-gated potassium channel subunit Kv1.5; KV1-5;
Gene Name
Kcna5
Gene Synonyms/Alias
Created Date
01-NOV-1997
 Lipid Modification Sites 
 Position   Sequence Form   Peptide   References   Modification Type 
593
Canonical
RRSLYALCLDTSRET
[1]
S-Palmitoylation
Organism
Mus musculus (Mouse)
NCBI Taxa ID
10090
Reference
[1] Jindal HK, Folco EJ, Liu GX, Koren G. Posttranslational modification ofvoltage-dependent potassium channel Kv1.5: COOH-terminal palmitoylation modulatesits biological properties. Am J Physiol Heart Circ Physiol. 2008May;294(5):H2012-21. doi: 10.1152/ajpheart.01374.2007. Epub 2008 Mar 14. PubMedPMID: 18344374.[PMID:18344374]
Functional Description
Mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient. This channel displays rapid activation and slow inactivation.
Sequence Annotation
Transmembrane: 242 260 Helical; Name=Segment S1.
Transmembrane: 316 336 Helical; Name=Segment S2.
Transmembrane: 347 368 Helical; Name=Segment S3.
Transmembrane: 387 408 Helical; Voltage-sensor; Name=Segment S4.
Transmembrane: 423 444 Helical; Name=Segment S5.
Transmembrane: 484 505 Helical; Name=Segment S6.
Motif: 469 474 Selectivity filter.
Motif: 600 602 PDZ-binding.
Modified residue: 81 81 Phosphoserine; by CK2 and PKA.
Modified residue: 535 535 Phosphoserine; by PKA.
Modified residue: 546 546 Phosphoserine; by PKA.
Modified residue: 569 569 Phosphoserine; by PKA.
Protein Length
602 AA.
Protein Sequence
(Canonical)
MEISLVPMEN GSAMTLRGGG EAGASCVQSP RGECGCPPTA GLNNQSKETS PRRRATHEDA  60
GQGGRPLPPM PQELPQPRRP SAEDEEGEGD PGLGTVEEDQ APQDSGSLHH QRVLINISGL  120
RFETQLGTLA QFPNTLLGDP VKRLRYFDPL RNEYFFDRNR PSFDGILYYY QSGGRLRRPV  180
NVSLDVFADE IRFYQLGDEA MERFREDEGF IKEEEKPLPR NEFQRQVWLI FEYPESSGSA  240
RAIAIVSVLV ILISIITFCL ETLPEFRDER ELLRHPPVPP QPPAPAPGAN GSGSGVLSSG  300
PTVAPLLPRT LADPFFIVET TCVIWFTFEL LVRFFACPSK AEFSRNIMNI IDIVAIFPYF  360
ITLGTELAEQ QPGGGGQNGQ QAMSLAILRV IRLVRVFRIF KLSRHSKGLQ ILGKTLQASM  420
RELGLLIFFL FIGVILFSSA VYFAEADNQG SHFSSIPDAF WWAVVTMTTV GYGDMRPITV  480
GGKIVGSLCA IAGVLTIALP VPVIVSNFNY FYHRETDHEE QAALKEEQGI QRRESGLDTG  540
GQRKVSCSKA SFCKTGGPLE STDSIRRGSC PLEKCHLKAK SNVDLRRSLY ALCLDTSRET  600
DL                                                                 602
FASTA
(Canonical)
>LipidDB-10090-01415|Q61762
MEISLVPMENGSAMTLRGGGEAGASCVQSPRGECGCPPTAGLNNQSKETSPRRRATHEDA
GQGGRPLPPMPQELPQPRRPSAEDEEGEGDPGLGTVEEDQAPQDSGSLHHQRVLINISGL
RFETQLGTLAQFPNTLLGDPVKRLRYFDPLRNEYFFDRNRPSFDGILYYYQSGGRLRRPV
NVSLDVFADEIRFYQLGDEAMERFREDEGFIKEEEKPLPRNEFQRQVWLIFEYPESSGSA
RAIAIVSVLVILISIITFCLETLPEFRDERELLRHPPVPPQPPAPAPGANGSGSGVLSSG
PTVAPLLPRTLADPFFIVETTCVIWFTFELLVRFFACPSKAEFSRNIMNIIDIVAIFPYF
ITLGTELAEQQPGGGGQNGQQAMSLAILRVIRLVRVFRIFKLSRHSKGLQILGKTLQASM
RELGLLIFFLFIGVILFSSAVYFAEADNQGSHFSSIPDAFWWAVVTMTTVGYGDMRPITV
GGKIVGSLCAIAGVLTIALPVPVIVSNFNYFYHRETDHEEQAALKEEQGIQRRESGLDTG
GQRKVSCSKASFCKTGGPLESTDSIRRGSCPLEKCHLKAKSNVDLRRSLYALCLDTSRET
DL
Gene Ontology
GO:0005783; C:endoplasmic reticulum; IEA:Ensembl
GO:0005794; C:Golgi apparatus; IEA:Ensembl
GO:0005887; C:integral component of plasma membrane; IC:MGI
GO:0014704; C:intercalated disc; IDA:MGI
GO:0046691; C:intracellular canaliculus; IEA:Ensembl
GO:0016020; C:membrane; IDA:MGI
GO:0045121; C:membrane raft; IEA:Ensembl
GO:0048471; C:perinuclear region of cytoplasm; IEA:Ensembl
GO:0005886; C:plasma membrane; IDA:MGI
GO:0008076; C:voltage-gated potassium channel complex; IEA:Ensembl
GO:0030018; C:Z disc; IEA:Ensembl
GO:0005251; F:delayed rectifier potassium channel activity; IBA:RefGenome
GO:0015271; F:outward rectifier potassium channel activity; IEA:Ensembl
GO:0019870; F:potassium channel inhibitor activity; IDA:MGI
GO:0005249; F:voltage-gated potassium channel activity; IDA:MGI
GO:0086089; F:voltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarization; IEA:Ensembl
GO:0060081; P:membrane hyperpolarization; IEA:Ensembl
GO:0051481; P:negative regulation of cytosolic calcium ion concentration; IEA:Ensembl
GO:0043267; P:negative regulation of potassium ion transport; IDA:MGI
GO:1900087; P:positive regulation of G1/S transition of mitotic cell cycle; IEA:Ensembl
GO:2000288; P:positive regulation of myoblast proliferation; IEA:Ensembl
GO:0071435; P:potassium ion export; IEA:Ensembl
GO:0055075; P:potassium ion homeostasis; IEA:Ensembl
GO:0006813; P:potassium ion transport; IDA:MGI
GO:0051260; P:protein homooligomerization; IEA:InterPro
GO:0060372; P:regulation of atrial cardiac muscle cell membrane repolarization; IEA:Ensembl
GO:0086091; P:regulation of heart rate by cardiac conduction; IEA:Ensembl
GO:0042391; P:regulation of membrane potential; IGI:MGI
GO:0019229; P:regulation of vasoconstriction; IMP:MGI
GO:0001666; P:response to hypoxia; IEA:Ensembl
Interpro
InterPro; IPR000210; BTB/POZ-like
InterPro; IPR011333; BTB/POZ_fold
InterPro; IPR027359; Channel_four-helix_dom
InterPro; IPR005821; Ion_trans_dom
InterPro; IPR003091; K_chnl
InterPro; IPR003968; K_chnl_volt-dep_Kv
InterPro; IPR003972; K_chnl_volt-dep_Kv1
InterPro; IPR004052; K_chnl_volt-dep_Kv1.5
InterPro; IPR003131; T1-type_BTB
InterPro; IPR028325; VG_K_chnl
Pfam
Pfam; PF02214; BTB_2;
Pfam; PF00520; Ion_trans;
SMART
SMART; SM00225; BTB;
PROSITE
PRINTS
PRINTS; PR00169; KCHANNEL;
PRINTS; PR01512; KV15CHANNEL;
PRINTS; PR01491; KVCHANNEL;
PRINTS; PR01496; SHAKERCHANEL;