LipidDB-10090-01382

Lipid Modification Database

Tag

Content

LipidDB ID

LipidDB-10090-01382

Entry Name

SERA_MOUSE

UniProt Accession

Q61753; Q3TEE5; Q75SV9; Q8C603;

Theoretical PI

6.12

Molecular Weight

56585.51

Genbank Protein ID

BAD08449.1; BAC36494.1; BAE41303.1; AAH86668.1; AAI10674.1; AAB67986.1;

Genbank Nucleotide ID

AB128936; AK076815; AK169684; BC086668; BC110673; L21027;

Protein Name

D-3-phosphoglycerate dehydrogenase

Protein Synonyms/Alias

3-PGDH; 1.1.1.95; A10;

Gene Name

Phgdh

Gene Synonyms/Alias

Created Date

15-JUL-1998

Lipid Modification Sites
Position	Sequence Form	Peptide	References	Modification Type
18	Canonical	ISDSLDPCCRKILQD	[1]	S-Palmitoylation
19	Canonical	SDSLDPCCRKILQDG	[1]	S-Palmitoylation
116	Canonical	LTCGMIMCLARQIPQ	[1]	S-Palmitoylation

Organism

Mus musculus (Mouse)

NCBI Taxa ID

10090

Reference

[1] Predicted from GPS-Lipid

Functional Description

Sequence Annotation

Nucleotide-binding: 155 156 NAD.
Nucleotide-binding: 234 236 NAD.
Nucleotide-binding: 283 286 NAD.
Active site: 236 236
Active site: 265 265
Active site: 283 283 Proton donor.
Binding site: 78 78 NAD.
Binding site: 175 175 NAD.
Binding site: 207 207 NAD; via carbonyl oxygen.
Binding site: 260 260 NAD.
Modified residue: 2 2 N-acetylalanine.
Modified residue: 21 21 N6-acetyllysine.
Modified residue: 58 58 N6-acetyllysine.

Protein Length

533 AA.

Protein Sequence
(Canonical)

MAFANLRKVL ISDSLDPCCR KILQDGGLQV VEKQNLSKEE LIAELQDCEG LIVRSATKVT  60
ADVINAAEKL QVVGRAGTGV DNVDLEAATR KGILVMNTPN GNSLSAAELT CGMIMCLARQ  120
IPQATASMKD GKWDRKKFMG TELNGKTLGI LGLGRIGREV ATRMQSFGMK TVGYDPIISP  180
EVAASFGVQQ LPLEEIWPLC DFITVHTPLL PSTTGLLNDS TFAQCKKGVR VVNCARGGIV  240
DEGALLRALQ SGQCAGAALD VFTEEPPRDR ALVDHENVIS CPHLGASTKE AQSRCGEEIA  300
VQFVDMVKGK SLTGVVNAQA LTSAFSPHTK PWIGLAEAMG TLMHAWAGSP KGTIQVVTQG  360
TSLKNAGTCL SPAVIVGLLR EASKQADVNL VNAKLLVKEA GLNVTTSHNP GVPGEQGSGE  420
CLLTVALAGA PYQAVGLVQG TTPMLQMLNG AVFRPEVPLR RGQPLLVFRA QPSDPGMLPT  480
MIGLLAEAGV QLLSYQTSMV SDGEPWHVMG LSSLLPSLET WKQHVLEAFQ FCF         533

FASTA
(Canonical)

>LipidDB-10090-01382|Q61753
MAFANLRKVLISDSLDPCCRKILQDGGLQVVEKQNLSKEELIAELQDCEGLIVRSATKVT
ADVINAAEKLQVVGRAGTGVDNVDLEAATRKGILVMNTPNGNSLSAAELTCGMIMCLARQ
IPQATASMKDGKWDRKKFMGTELNGKTLGILGLGRIGREVATRMQSFGMKTVGYDPIISP
EVAASFGVQQLPLEEIWPLCDFITVHTPLLPSTTGLLNDSTFAQCKKGVRVVNCARGGIV
DEGALLRALQSGQCAGAALDVFTEEPPRDRALVDHENVISCPHLGASTKEAQSRCGEEIA
VQFVDMVKGKSLTGVVNAQALTSAFSPHTKPWIGLAEAMGTLMHAWAGSPKGTIQVVTQG
TSLKNAGTCLSPAVIVGLLREASKQADVNLVNAKLLVKEAGLNVTTSHNPGVPGEQGSGE
CLLTVALAGAPYQAVGLVQGTTPMLQMLNGAVFRPEVPLRRGQPLLVFRAQPSDPGMLPT
MIGLLAEAGVQLLSYQTSMVSDGEPWHVMGLSSLLPSLETWKQHVLEAFQFCF

Gene Ontology

GO:0070062; C:extracellular vesicular exosome; IEA:Ensembl
GO:0051287; F:NAD binding; IEA:InterPro
GO:0004617; F:phosphoglycerate dehydrogenase activity; TAS:MGI
GO:0070314; P:G1 to G0 transition; IMP:MGI
GO:0009448; P:gamma-aminobutyric acid metabolic process; IMP:MGI
GO:0021782; P:glial cell development; IMP:MGI
GO:0006541; P:glutamine metabolic process; IMP:MGI
GO:0006544; P:glycine metabolic process; IMP:MGI
GO:0006564; P:L-serine biosynthetic process; IEA:UniProtKB-KW
GO:0006563; P:L-serine metabolic process; IMP:MGI
GO:0021915; P:neural tube development; IMP:MGI
GO:0022008; P:neurogenesis; IMP:MGI
GO:0031175; P:neuron projection development; IMP:MGI
GO:0010468; P:regulation of gene expression; IMP:MGI
GO:0021510; P:spinal cord development; IMP:MGI
GO:0019530; P:taurine metabolic process; IMP:MGI
GO:0006566; P:threonine metabolic process; IMP:MGI

Interpro

InterPro; IPR029009; ASB_dom
InterPro; IPR006139; D-isomer_2_OHA_DH_cat_dom
InterPro; IPR029753; D-isomer_DH_CS
InterPro; IPR029752; D-isomer_DH_CS1
InterPro; IPR006140; D-isomer_DH_NAD-bd
InterPro; IPR016040; NAD(P)-bd_dom
InterPro; IPR006236; PGDH

Pfam

Pfam; PF00389; 2-Hacid_dh;
Pfam; PF02826; 2-Hacid_dh_C;

SMART

PROSITE

PROSITE; PS00065; D_2_HYDROXYACID_DH_1;
PROSITE; PS00670; D_2_HYDROXYACID_DH_2;
PROSITE; PS00671; D_2_HYDROXYACID_DH_3;

PRINTS