LipidDB ID

LipidDB-10090-01381

Entry Name

UniProt Accession

O54957;

Theoretical PI

3.86

Molecular Weight

26014.5

Genbank Protein ID

AAC40054.1; AAH13337.1;

Genbank Nucleotide ID

AF036907; BC013337;

Protein Name

Linker for activation of T-cells family member 1

Protein Synonyms/Alias

36 kDa phospho-tyrosine adapter protein; pp36; p36-38;

Gene Name

Lat

Gene Synonyms/Alias

Created Date

01-JUN-2001

Organism

Mus musculus (Mouse)

NCBI Taxa ID

10090

Reference

[1] Van Laethem F, Liang X, Andris F, Urbain J, Vandenbranden M, Ruysschaert JM,Resh MD, Stulnig TM, Leo O. Glucocorticoids alter the lipid and proteincomposition of membrane rafts of a murine T cell hybridoma. J Immunol. 2003 Mar15;170(6):2932-9.[PMID:12626544]
[2] Hundt M, Harada Y, De Giorgio L, Tanimura N, Zhang W, Altman A.Palmitoylation-dependent plasma membrane transport but lipid raft-independentsignaling by linker for activation of T cells. J Immunol. 2009 Aug1;183(3):1685-94. doi: 10.4049/jimmunol.0803921. Epub 2009 Jul 10.[PMID:19592663]

Functional Description

Required for TCR (T-cell antigen receptor)- and pre-TCR- mediated signaling, both in mature T-cells and during their development. Involved in FCGR3 (low affinity immunoglobulin gamma Fc region receptor III)-mediated signaling in natural killer cells and FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Couples activation of these receptors and their associated kinases with distal intracellular events such as mobilization of intracellular calcium stores, PKC activation, MAPK activation or cytoskeletal reorganization through the recruitment of PLCG1, GRB2, GRAP2, and other signaling molecules.

Sequence Annotation

Topological domain: 1 4 Extracellular.
Transmembrane: 5 28 Helical; Signal-anchor for type IIImembrane protein.
Topological domain: 29 242 Cytoplasmic.
Region: 136 139 Interaction with PLCG1.
Region: 175 178 Interaction with GRB2, GRAP2 and PIK3R1.
Region: 195 198 Interaction with GRB2, GRAP2 and PIK3R1.
Modified residue: 40 40 Phosphothreonine.
Modified residue: 41 41 Phosphoserine.
Modified residue: 44 44 Phosphoserine.
Modified residue: 87 87 Phosphoserine.
Modified residue: 104 104 Phosphoserine.
Modified residue: 109 109 Phosphoserine.
Modified residue: 175 175 Phosphotyrosine.
Modified residue: 199 199 Phosphoserine.
Modified residue: 215 215 Phosphoserine.
Modified residue: 235 235 Phosphotyrosine.

Protein Length

242 AA.

Protein Sequence
(Canonical)

FASTA
(Canonical)

Gene Ontology

GO:0005911; C:cell-cell junction; IDA:MGI
GO:0008180; C:COP9 signalosome; IDA:UniProtKB
GO:0001772; C:immunological synapse; IDA:MGI
GO:0005887; C:integral component of plasma membrane; TAS:MGI
GO:0042629; C:mast cell granule; IEA:GOC
GO:0005057; F:receptor signaling protein activity; TAS:MGI
GO:0005070; F:SH3/SH2 adaptor activity; ISS:HGNC
GO:0019722; P:calcium-mediated signaling; ISS:HGNC
GO:0006968; P:cellular defense response; TAS:MGI
GO:0010467; P:gene expression; IMP:MGI
GO:0048872; P:homeostasis of number of cells; IMP:MGI
GO:0006955; P:immune response; ISS:HGNC
GO:0006954; P:inflammatory response; IMP:MGI
GO:0007229; P:integrin-mediated signaling pathway; ISS:HGNC
GO:0035556; P:intracellular signal transduction; ISS:HGNC
GO:0002260; P:lymphocyte homeostasis; IMP:MGI
GO:0043303; P:mast cell degranulation; IEA:UniProtKB-KW
GO:0007265; P:Ras protein signal transduction; ISS:HGNC
GO:0050863; P:regulation of T cell activation; ISS:HGNC
GO:0007169; P:transmembrane receptor protein tyrosine kinase signaling pathway; TAS:MGI

Interpro

InterPro; IPR008359; Linker_for_activat_Tcells_prot

Pfam

Pfam; PF15234; LAT;

SMART

PROSITE

PRINTS

PRINTS; PR01781; LATPROTEIN;