LipidDB-10090-01370

Lipid Modification Database

Tag

Content

LipidDB ID

LipidDB-10090-01370

Entry Name

SSR5_MOUSE

UniProt Accession

O08858; A6H6N8; O08998; Q3UZM7;

Theoretical PI

9.54

Molecular Weight

40008.3

Genbank Protein ID

AAC53353.1; AAB61418.1; AAB86492.1; AAB88302.1; BAE21747.1; BAE21829.1; AAI45944.1; AAI50806.1;

Genbank Nucleotide ID

U82697; AF004740; AF030441; AF035777; AK133609; AK133767; AC131323; BC145943; BC150805;

Protein Name

Somatostatin receptor type 5

Protein Synonyms/Alias

SS-5-R; SS5-R; SS5R;

Gene Name

Sstr5

Gene Synonyms/Alias

Smstr5;

Created Date

01-NOV-1997

Lipid Modification Sites
Position	Sequence Form	Peptide	References	Modification Type
319	Canonical	QSFRKALCLRRGYGV	[1]	S-Palmitoylation

Organism

Mus musculus (Mouse)

NCBI Taxa ID

10090

Reference

[1] Kokkola T, Kruse C, Roy-Pogodzik EM, Pekkinen J, Bauch C, Hönck HH, Hennemann H, Kreienkamp HJ. Somatostatin receptor 5 is palmitoylated by the interactingZDHHC5 palmitoyltransferase. FEBS Lett. 2011 Sep 2;585(17):2665-70. doi:10.1016/j.febslet.2011.07.028. Epub 2011 Jul 31.[PMID:21820437]

Functional Description

Receptor for somatostatin-28. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase. Increases cell growth inhibition activity of SSTR2 following heterodimerization.

Sequence Annotation

Topological domain: 1 35 Extracellular.
Transmembrane: 36 63 Helical; Name=1.
Topological domain: 64 73 Cytoplasmic.
Transmembrane: 74 99 Helical; Name=2.
Topological domain: 100 110 Extracellular.
Transmembrane: 111 132 Helical; Name=3.
Topological domain: 133 154 Cytoplasmic.
Transmembrane: 155 175 Helical; Name=4.
Topological domain: 176 195 Extracellular.
Transmembrane: 196 220 Helical; Name=5.
Topological domain: 221 246 Cytoplasmic.
Transmembrane: 247 272 Helical; Name=6.
Topological domain: 273 282 Extracellular.
Transmembrane: 283 307 Helical; Name=7.
Topological domain: 308 362 Cytoplasmic.

Protein Length

362 AA.

Protein Sequence
(Canonical)

MEPLSLTSTP SWNASAASSS SHNWSLVDPV SPMGARAVLV PVLYLLVCTV GLGGNTLVIY  60
VVLRYAKMKT VTNVYILNLA VADVLFMLGL PFLATQNAVS YWPFGSFLCR LVMTLDGINQ  120
FTSIFCLMVM SVDRYLAVVH PLRSARWRRP RVAKLASAAV WVFSLLMSLP LLVFADVQEG  180
WGTCNLSWPE PVGLWGAAFI TYTSVLGFFG PLLVICLCYL LIVVKVKAAG MRVGSSRRRR  240
SERKVTRMVV VVVLVFVGCW LPFFIVNIVN LAFTLPEEPT SAGLYFFVVV LSYANSCANP  300
LLYGFLSDNF RQSFRKALCL RRGYGVEDAD AIEPRPDKSG RPQTTLPTRS CEANGLMQTS  360
RL                                                                 362

FASTA
(Canonical)

>LipidDB-10090-01370|O08858
MEPLSLTSTPSWNASAASSSSHNWSLVDPVSPMGARAVLVPVLYLLVCTVGLGGNTLVIY
VVLRYAKMKTVTNVYILNLAVADVLFMLGLPFLATQNAVSYWPFGSFLCRLVMTLDGINQ
FTSIFCLMVMSVDRYLAVVHPLRSARWRRPRVAKLASAAVWVFSLLMSLPLLVFADVQEG
WGTCNLSWPEPVGLWGAAFITYTSVLGFFGPLLVICLCYLLIVVKVKAAGMRVGSSRRRR
SERKVTRMVVVVVLVFVGCWLPFFIVNIVNLAFTLPEEPTSAGLYFFVVVLSYANSCANP
LLYGFLSDNFRQSFRKALCLRRGYGVEDADAIEPRPDKSGRPQTTLPTRSCEANGLMQTS
RL

Gene Ontology

GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW
GO:0005886; C:plasma membrane; IDA:MGI
GO:0004994; F:somatostatin receptor activity; IEA:InterPro
GO:0042593; P:glucose homeostasis; IMP:MGI
GO:0032467; P:positive regulation of cytokinesis; IEA:Ensembl
GO:0050796; P:regulation of insulin secretion; IMP:MGI

Interpro

InterPro; IPR000276; GPCR_Rhodpsn
InterPro; IPR017452; GPCR_Rhodpsn_7TM
InterPro; IPR000586; Somatstn_rcpt
InterPro; IPR001184; Somatstn_rcpt_5

Pfam

Pfam; PF00001; 7tm_1;

SMART

PROSITE

PROSITE; PS00237; G_PROTEIN_RECEP_F1_1;
PROSITE; PS50262; G_PROTEIN_RECEP_F1_2;

PRINTS

PRINTS; PR00237; GPCRRHODOPSN;
PRINTS; PR00246; SOMATOSTATNR;
PRINTS; PR00591; SOMATOSTTN5R;