LipidDB ID

LipidDB-10090-01352

Entry Name

UniProt Accession

P32883; P04200; P08643;

Theoretical PI

6.33

Molecular Weight

21655.83

Genbank Protein ID

CAA26295.1; CAA26295.1; CAA26295.1; CAA26295.1; CAA26296.1; AAH04642.1; AAH10202.1; AAA40037.1; CAA25160.1;

Genbank Nucleotide ID

X02452; X02453; X02454; X02456; X02455; BC004642; BC010202; K01927; X00485;

Protein Name

GTPase KRas, N-terminally processed

Protein Synonyms/Alias

K-Ras 2; Ki-Ras; c-K-ras; c-Ki-ras;

Gene Name

Kras

Gene Synonyms/Alias

Kras2;

Created Date

20-MAR-1987

Organism

Mus musculus (Mouse)

NCBI Taxa ID

10090

Reference

[1] Predicted from GPS-Lipid

Functional Description

Ras proteins bind GDP/GTP and possess intrinsic GTPase activity.

Sequence Annotation

Nucleotide-binding: 10 17 GTP.
Nucleotide-binding: 57 61 GTP.
Nucleotide-binding: 116 119 GTP.
Region: 166 185 Hypervariable region.
Motif: 32 40 Effector region.
Modified residue: 1 1 N-acetylmethionine.
Modified residue: 2 2 N-acetylthreonine; in GTPase KRas, N-terminally processed.
Modified residue: 104 104 N6-acetyllysine.
Modified residue: 186 186 Cysteine methyl ester; in isoform 2A.

Protein Length

189 AA.

Protein Sequence
(Canonical)

FASTA
(Canonical)

Gene Ontology

GO:0016020; C:membrane; IDA:MGI
GO:0045121; C:membrane raft; IEA:Ensembl
GO:0005739; C:mitochondrion; IEA:Ensembl
GO:0005886; C:plasma membrane; TAS:Reactome
GO:0019003; F:GDP binding; IEA:Ensembl
GO:0019002; F:GMP binding; IEA:Ensembl
GO:0005525; F:GTP binding; IEA:UniProtKB-KW
GO:0003924; F:GTPase activity; IGI:MGI
GO:0032403; F:protein complex binding; ISO:MGI
GO:0030036; P:actin cytoskeleton organization; IGI:MGI
GO:0019221; P:cytokine-mediated signaling pathway; IEA:Ensembl
GO:0060441; P:epithelial tube branching involved in lung morphogenesis; IDA:MGI
GO:0045596; P:negative regulation of cell differentiation; IDA:MGI
GO:0043524; P:negative regulation of neuron apoptotic process; IGI:MGI
GO:0008284; P:positive regulation of cell proliferation; IGI:MGI
GO:0010628; P:positive regulation of gene expression; IEA:Ensembl
GO:0043406; P:positive regulation of MAP kinase activity; IEA:Ensembl
GO:0051092; P:positive regulation of NF-kappaB transcription factor activity; IEA:Ensembl
GO:0051000; P:positive regulation of nitric-oxide synthase activity; IEA:Ensembl
GO:0035022; P:positive regulation of Rac protein signal transduction; IGI:MGI
GO:0007265; P:Ras protein signal transduction; IGI:MGI
GO:0048169; P:regulation of long-term neuronal synaptic plasticity; IGI:MGI
GO:0032228; P:regulation of synaptic transmission, GABAergic; IGI:MGI
GO:0051384; P:response to glucocorticoid; IEA:Ensembl
GO:0051385; P:response to mineralocorticoid; IEA:Ensembl
GO:0035176; P:social behavior; IEA:Ensembl
GO:0051146; P:striated muscle cell differentiation; IGI:MGI
GO:0008542; P:visual learning; IGI:MGI

Interpro

InterPro; IPR027417; P-loop_NTPase
InterPro; IPR005225; Small_GTP-bd_dom
InterPro; IPR001806; Small_GTPase
InterPro; IPR020849; Small_GTPase_Ras

Pfam

Pfam; PF00071; Ras;

SMART

SMART; SM00173; RAS;

PROSITE

PROSITE; PS51421; RAS;

PRINTS

PRINTS; PR00449; RASTRNSFRMNG;