Lipid Modification Database
Tag Content
LipidDB ID
LipidDB-10090-01333
Entry Name
UniProt Accession
Theoretical PI
5.57
Molecular Weight
29820.1
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
Prohibitin
Protein Synonyms/Alias
B-cell receptor-associated protein 32; BAP 32;
Gene Name
Phb
Gene Synonyms/Alias
Created Date
11-OCT-2004
 Lipid Modification Sites 
 Position   Sequence Form   Peptide   References   Modification Type 
69
Canonical
QKPIIFDCRSRPRNV
[1]
S-Palmitoylation
Organism
Mus musculus (Mouse)
NCBI Taxa ID
10090
Reference
[1] Predicted from GPS-Lipid
Functional Description
Prohibitin inhibits DNA synthesis. It has a role in regulating proliferation. As yet it is unclear if the protein or the mRNA exhibits this effect. May play a role in regulating mitochondrial respiration activity and in aging (By similarity).
Sequence Annotation
Modified residue: 128 128 N6-acetyllysine.
Modified residue: 186 186 N6-acetyllysine.
Modified residue: 202 202 N6-acetyllysine; alternate.
Modified residue: 202 202 N6-succinyllysine; alternate.
Modified residue: 249 249 Phosphotyrosine.
Protein Length
272 AA.
Protein Sequence
(Canonical)
MAAKVFESIG KFGLALAVAG GVVNSALYNV DAGHRAVIFD RFRGVQDIVV GEGTHFLIPW  60
VQKPIIFDCR SRPRNVPVIT GSKDLQNVNI TLRILFRPVA SQLPRIYTSI GEDYDERVLP  120
SITTEILKSV VARFDAGELI TQRELVSRQV SDDLTERAAT FGLILDDVSL THLTFGKEFT  180
EAVEAKQVAQ QEAERARFVV EKAEQQKKAA IISAEGDSKA AELIANSLAT AGDGLIELRK  240
LEAAEDIAYQ LSRSRNITYL PAGQSVLLQL PQ                                272
FASTA
(Canonical)
>LipidDB-10090-01333|P67778
MAAKVFESIGKFGLALAVAGGVVNSALYNVDAGHRAVIFDRFRGVQDIVVGEGTHFLIPW
VQKPIIFDCRSRPRNVPVITGSKDLQNVNITLRILFRPVASQLPRIYTSIGEDYDERVLP
SITTEILKSVVARFDAGELITQRELVSRQVSDDLTERAATFGLILDDVSLTHLTFGKEFT
EAVEAKQVAQQEAERARFVVEKAEQQKKAAIISAEGDSKAAELIANSLATAGDGLIELRK
LEAAEDIAYQLSRSRNITYLPAGQSVLLQLPQ
Gene Ontology
GO:0070062; C:extracellular vesicular exosome; IEA:Ensembl
GO:0005887; C:integral component of plasma membrane; IEA:Ensembl
GO:0005743; C:mitochondrial inner membrane; IDA:MGI
GO:0005739; C:mitochondrion; IDA:MGI
GO:0005654; C:nucleoplasm; IEA:Ensembl
GO:0005634; C:nucleus; IDA:MGI
GO:0000981; F:sequence-specific DNA binding RNA polymerase II transcription factor activity; IDA:MGI
GO:0044212; F:transcription regulatory region DNA binding; IEA:Ensembl
GO:0071354; P:cellular response to interleukin-6; IEA:Ensembl
GO:0071897; P:DNA biosynthetic process; IMP:MGI
GO:0006260; P:DNA replication; IEA:UniProtKB-KW
GO:0016575; P:histone deacetylation; IEA:Ensembl
GO:0060766; P:negative regulation of androgen receptor signaling pathway; IEA:Ensembl
GO:0030308; P:negative regulation of cell growth; IEA:Ensembl
GO:0008285; P:negative regulation of cell proliferation; IEA:Ensembl
GO:2000323; P:negative regulation of glucocorticoid receptor signaling pathway; IEA:Ensembl
GO:0010944; P:negative regulation of transcription by competitive promoter binding; IEA:Ensembl
GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; IDA:MGI
GO:0001649; P:osteoblast differentiation; IEA:Ensembl
GO:0045893; P:positive regulation of transcription, DNA-templated; IEA:Ensembl
GO:0050847; P:progesterone receptor signaling pathway; IEA:Ensembl
GO:0006366; P:transcription from RNA polymerase II promoter; IDA:GOC
Interpro
InterPro; IPR001107; Band_7
InterPro; IPR000163; Prohibitin
Pfam
Pfam; PF01145; Band_7;
SMART
SMART; SM00244; PHB;
PROSITE
PRINTS
PRINTS; PR00679; PROHIBITIN;