LipidDB ID

LipidDB-10090-01312

Entry Name

UniProt Accession

Q8C180;

Theoretical PI

5.8

Molecular Weight

56793.91

Genbank Protein ID

BAC26132.1; AAH43109.1; AAH55334.1;

Genbank Nucleotide ID

AK028813; BC043109; BC055334;

Protein Name

Fibroblast growth factor receptor substrate 2

Protein Synonyms/Alias

FGFR substrate 2; FGFR-signaling adaptor SNT; FRS2-alpha; Suc1-associated neurotrophic factor target 1; SNT-1;

Gene Name

Frs2

Gene Synonyms/Alias

Frs2a;

Created Date

19-JUL-2005

Organism

Mus musculus (Mouse)

NCBI Taxa ID

10090

Reference

[1] Kouhara H, Hadari YR, Spivak-Kroizman T, Schilling J, Bar-Sagi D, Lax I,Schlessinger J. A lipid-anchored Grb2-binding protein that links FGF-receptoractivation to the Ras/MAPK signaling pathway. Cell. 1997 May 30;89(5):693-702.[PMID:9182757]

Functional Description

Adapter protein that links activated FGR and NGF receptors to downstream signaling pathways. Plays an important role in the activation of MAP kinases and in the phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3- kinase, in response to ligand-mediated activation of FGFR1. Modulates signaling via SHC1 by competing for a common binding site on NTRK1.

Sequence Annotation

Domain: 13 115 IRS-type PTB.
Modified residue: 196 196 Phosphotyrosine; by FGFR1.
Modified residue: 211 211 Phosphoserine.
Modified residue: 221 221 Phosphoserine.
Modified residue: 306 306 Phosphotyrosine; by FGFR1.
Modified residue: 349 349 Phosphotyrosine; by FGFR1.
Modified residue: 392 392 Phosphotyrosine; by FGFR1.
Modified residue: 436 436 Phosphotyrosine; by FGFR1.
Modified residue: 471 471 Phosphotyrosine; by FGFR1.

Protein Length

508 AA.

Protein Sequence
(Canonical)

FASTA
(Canonical)

Gene Ontology

GO:0005911; C:cell-cell junction; IDA:MGI
GO:0005737; C:cytoplasm; IDA:MGI
GO:0005886; C:plasma membrane; IDA:MGI
GO:0005068; F:transmembrane receptor protein tyrosine kinase adaptor activity; IDA:MGI
GO:0000187; P:activation of MAPK activity; IMP:MGI
GO:0008595; P:anterior/posterior axis specification, embryo; IMP:MGI
GO:0008543; P:fibroblast growth factor receptor signaling pathway; IMP:MGI
GO:0030900; P:forebrain development; IMP:MGI
GO:0001702; P:gastrulation with mouth forming second; IMP:MGI
GO:0002088; P:lens development in camera-type eye; IMP:MGI
GO:0070307; P:lens fiber cell development; IMP:MGI
GO:0007405; P:neuroblast proliferation; IMP:MGI
GO:0046619; P:optic placode formation involved in camera-type eye formation; IMP:MGI
GO:0001759; P:organ induction; IMP:MGI
GO:0060527; P:prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis; IMP:MGI
GO:0042981; P:regulation of apoptotic process; IMP:MGI
GO:0050678; P:regulation of epithelial cell proliferation; IMP:MGI
GO:0070372; P:regulation of ERK1 and ERK2 cascade; IMP:MGI
GO:0007169; P:transmembrane receptor protein tyrosine kinase signaling pathway; IDA:MGI
GO:0003281; P:ventricular septum development; IMP:MGI

Interpro

InterPro; IPR002404; Insln_rcpt_S1
InterPro; IPR011993; PH_like_dom

Pfam

Pfam; PF02174; IRS;

SMART

SMART; SM00310; PTBI;

PROSITE

PROSITE; PS51064; IRS_PTB;

PRINTS