LipidDB ID

LipidDB-10090-01297

Entry Name

UniProt Accession

Q9EPU5; Q3UYG3; Q543Y9; Q91W77; Q91XH9;

Theoretical PI

7.28

Molecular Weight

71982.85

Genbank Protein ID

AAG38115.1; AAK74193.1; BAC31664.1; BAE22249.1; AAH16420.1;

Genbank Nucleotide ID

AF322069; AY043489; AK043823; AK134704; BC016420;

Protein Name

Tumor necrosis factor receptor superfamily member 21

Protein Synonyms/Alias

Death receptor 6; CD358;

Gene Name

Tnfrsf21

Gene Synonyms/Alias

Dr6;

Created Date

27-MAY-2002

Organism

Mus musculus (Mouse)

NCBI Taxa ID

10090

Reference

[1] Klíma M, Zájedová J, Doubravská L, Andera L. Functional analysis of theposttranslational modifications of the death receptor 6. Biochim Biophys Acta.2009 Oct;1793(10):1579-87. doi: 10.1016/j.bbamcr.2009.07.008. Epub 2009 Aug 3.[PMID:19654028]

Functional Description

Promotes apoptosis, possibly via a pathway that involves the activation of NF-kappa-B. Can also promote apoptosis mediated by BAX and by the release of cytochrome c from the mitochondria into the cytoplasm. Plays a role in neuronal apoptosis, including apoptosis in response to amyloid peptides derived from APP, and is required for both normal cell body death and axonal pruning. Trophic-factor deprivation triggers the cleavage of surface APP by beta-secretase to release sAPP-beta which is further cleaved to release an N-terminal fragment of APP (N-APP). N-APP binds TNFRSF21; this triggers caspase activation and degeneration of both neuronal cell bodies (via caspase-3) and axons (via caspase- 6). Negatively regulates oligodendrocyte survival, maturation and myelination. Plays a role in signaling cascades triggered by stimulation of T-cell receptors, in the adaptive immune response and in the regulation of T-cell differentiation and proliferation. Negatively regulates T-cell responses and the release of cytokines such as IL4, IL5, IL10, IL13 and IFNG by Th2 cells. Negatively regulates the production of IgG, IgM and IgM in response to antigens. May inhibit the activation of JNK in response to T-cell stimulation.

Sequence Annotation

Topological domain: 42 349 Extracellular.
Transmembrane: 350 370 Helical.
Topological domain: 371 655 Cytoplasmic.
Domain: 415 498 Death.

Protein Length

655 AA.

Protein Sequence
(Canonical)

FASTA
(Canonical)

Gene Ontology

GO:0030424; C:axon; IDA:UniProtKB
GO:0005887; C:integral component of plasma membrane; IEA:Ensembl
GO:0031226; C:intrinsic component of plasma membrane; IDA:UniProtKB
GO:0002250; P:adaptive immune response; IMP:UniProtKB
GO:0001783; P:B cell apoptotic process; IMP:UniProtKB
GO:0071356; P:cellular response to tumor necrosis factor; IEA:Ensembl
GO:0006959; P:humoral immune response; IMP:UniProtKB
GO:0042552; P:myelination; IMP:UniProtKB
GO:0030889; P:negative regulation of B cell proliferation; IMP:UniProtKB
GO:2001180; P:negative regulation of interleukin-10 secretion; IMP:UniProtKB
GO:2000666; P:negative regulation of interleukin-13 secretion; IMP:UniProtKB
GO:2000663; P:negative regulation of interleukin-5 secretion; IMP:UniProtKB
GO:0031642; P:negative regulation of myelination; IEA:Ensembl
GO:0042130; P:negative regulation of T cell proliferation; IMP:UniProtKB
GO:0051402; P:neuron apoptotic process; IMP:UniProtKB
GO:0097252; P:oligodendrocyte apoptotic process; IMP:UniProtKB
GO:0048713; P:regulation of oligodendrocyte differentiation; IMP:UniProtKB
GO:0050852; P:T cell receptor signaling pathway; IMP:UniProtKB

Interpro

InterPro; IPR011029; DEATH-like_dom
InterPro; IPR000488; Death_domain
InterPro; IPR001368; TNFR/NGFR_Cys_rich_reg
InterPro; IPR022330; TNFR_21

Pfam

Pfam; PF00531; Death;

SMART

SMART; SM00005; DEATH;
SMART; SM00208; TNFR;

PROSITE

PROSITE; PS50017; DEATH_DOMAIN;
PROSITE; PS00652; TNFR_NGFR_1;
PROSITE; PS50050; TNFR_NGFR_2;

PRINTS

PRINTS; PR01971; TNFACTORR21;