Lipid Modification Database
Tag Content
LipidDB ID
LipidDB-10090-01285
Entry Name
UniProt Accession
Theoretical PI
5.24
Molecular Weight
31172.41
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
Cation-dependent mannose-6-phosphate receptor
Protein Synonyms/Alias
CD Man-6-P receptor; CD-MPR; 46 kDa mannose 6-phosphate receptor; MPR 46;
Gene Name
M6pr
Gene Synonyms/Alias
46mpr;
Created Date
01-MAR-1992
 Lipid Modification Sites 
 Position   Sequence Form   Peptide   References   Modification Type 
7
Canonical
*MFPFSGCWRTELLL
[2]
S-Palmitoylation
241
Canonical
GNLVADGCDFVCRSK
[1]
S-Palmitoylation
245
Canonical
ADGCDFVCRSKPRNV
[1]
S-Palmitoylation
Organism
Mus musculus (Mouse)
NCBI Taxa ID
10090
Reference
[1] Schweizer A, Kornfeld S, Rohrer J. Cysteine34 of the cytoplasmic tail of thecation-dependent mannose 6-phosphate receptor is reversibly palmitoylated andrequired for normal trafficking and lysosomal enzyme sorting. J Cell Biol. 1996Feb;132(4):577-84.[PMID:8647889]
[2] Predicted from GPS-Lipid
Functional Description
Transport of phosphorylated lysosomal enzymes from the Golgi complex and the cell surface to lysosomes. Lysosomal enzymes bearing phosphomannosyl residues bind specifically to mannose-6- phosphate receptors in the Golgi apparatus and the resulting receptor-ligand complex is transported to an acidic prelyosomal compartment where the low pH mediates the dissociation of the complex.
Sequence Annotation
Topological domain: 22 186 Lumenal.
Transmembrane: 187 211 Helical.
Topological domain: 212 278 Cytoplasmic.
Modified residue: 268 268 Phosphoserine.
Protein Length
278 AA.
Protein Sequence
(Canonical)
MFPFSGCWRT ELLLLLLLAV AVRESWQIEE KSCDLVGEKD KESKNEVALL ERLRPLFNKS  60
FESTVGQGSD TYSYIFRVCR EASNHSSGAG LVQINKSNDK ETVVGRINET HIFNGSNWIM  120
LIYKGGDEYD NHCGKEQRRA VVMISCNRHT LAANFNPVSE ERGKVQDCFY LFEMDSSLAC  180
SPEVSHLSVG SILLVIFASL VAVYIIGGFL YQRLVVGAKG MEQFPHLAFW QDLGNLVADG  240
CDFVCRSKPR NVPAAYRGVG DDQLGEESEE RDDHLLPM                          278
FASTA
(Canonical)
>LipidDB-10090-01285|P24668
MFPFSGCWRTELLLLLLLAVAVRESWQIEEKSCDLVGEKDKESKNEVALLERLRPLFNKS
FESTVGQGSDTYSYIFRVCREASNHSSGAGLVQINKSNDKETVVGRINETHIFNGSNWIM
LIYKGGDEYDNHCGKEQRRAVVMISCNRHTLAANFNPVSEERGKVQDCFYLFEMDSSLAC
SPEVSHLSVGSILLVIFASLVAVYIIGGFLYQRLVVGAKGMEQFPHLAFWQDLGNLVADG
CDFVCRSKPRNVPAAYRGVGDDQLGEESEERDDHLLPM
Gene Ontology
GO:0005768; C:endosome; ISO:MGI
GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW
GO:0005770; C:late endosome; IDA:MGI
GO:0005764; C:lysosome; IEA:UniProtKB-KW
GO:0005537; F:mannose binding; IEA:InterPro
GO:0015578; F:mannose transmembrane transporter activity; IEA:InterPro
GO:0006886; P:intracellular protein transport; TAS:MGI
Interpro
InterPro; IPR028927; Man-6-P_rcpt
InterPro; IPR009011; Man6P_isomerase_rcpt-bd_dom
InterPro; IPR000296; Man_6_P_rcpt
Pfam
Pfam; PF02157; Man-6-P_recep;
SMART
PROSITE
PRINTS
PRINTS; PR00715; MAN6PRECEPTR;