| Tag |
Content |
LipidDB ID |
LipidDB-10090-01278 |
Entry Name |
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UniProt Accession |
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Theoretical PI |
4.94 |
Molecular Weight |
64172.72 |
Genbank Protein ID |
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Genbank Nucleotide ID |
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Protein Name |
AT-rich interactive domain-containing protein 3A |
Protein Synonyms/Alias |
ARID domain-containing protein 3A; B-cell regulator of IgH transcription; Bright; Dead ringer-like protein 1; |
Gene Name |
Arid3a |
Gene Synonyms/Alias |
Dri1; Dril1; |
Created Date |
11-JAN-2001 |
| Lipid Modification Sites |
|---|
| Position |
Sequence Form |
Peptide |
References |
Modification Type |
332 | Canonical | KYLYPYECERRGLSS | [1] | S-Palmitoylation |
|
Organism |
Mus musculus (Mouse) |
NCBI Taxa ID |
10090 |
Reference |
[1] Schmidt C, Kim D, Ippolito GC, Naqvi HR, Probst L, Mathur S, Rosas-Acosta G,Wilson VG, Oldham AL, Poenie M, Webb CF, Tucker PW. Signalling of the BCR isregulated by a lipid rafts-localised transcription factor, Bright. EMBO J. 2009Mar 18;28(6):711-24. doi: 10.1038/emboj.2009.20. Epub 2009 Feb 12.[ PMID:19214191]
|
Functional Description |
Transcription factor involved in B-cell differentiation. Binds a VH promoter proximal site necessary for induced mu-heavy- chain transcription. Binds the minor groove of a restricted ATC sequence that is sufficient for nuclear matrix association. This sequence motif is present in matrix-associating regions (MARS) proximal to the promoter and flanking E mu. Activates E mu-driven transcription by binding these sites. May be involved in the control of cell cycle progression by the RB1/E2F1 pathway. |
Sequence Annotation |
Domain: 243 335 ARID.
Domain: 449 546 REKLES.
Region: 128 165 Acidic.
Region: 450 493 Important for nuclear localization.
Region: 495 518 Homodimerization.
Region: 542 562 Important for cytoplasmic localization.
Modified residue: 78 78 Phosphoserine.
Modified residue: 82 82 Phosphoserine.
Modified residue: 89 89 Phosphoserine.
Modified residue: 99 99 Phosphothreonine.
Modified residue: 102 102 Phosphoserine.
Modified residue: 127 127 Phosphoserine.
|
Protein Length |
601 AA. |
Protein Sequence
(Canonical) |
MKLQAVMETL IQRQQRARQE LEARQAPPPP PPEPTGVRAR TTMTDEDREP ENARMHRTQM 60
AALAAMRAAA AGLGHPSSPG GSEDGPPISG DEDTAREGTL SSPALHGSVL EGAGHAEGDR 120
HLMDVGSDDD DTKSKWEEQE LEELGEEEEE EEEEDDFEEE EEEEEGLGPP ESASLGTAGL 180
FTRKAPPAQA FRGDGGPRML SGPERLGPGP AHPSHMASQM PPPDHGDWTF EEQFKQLYEL 240
DADPKRKEFL DDLFSFMQKR GTPVNRIPIM AKQVLDLFML YVLVTEKGGL VEVINKKLWR 300
EITKGLNLPT SITSAAFTLR TQYMKYLYPY ECERRGLSSP NELQAAIDSN RREGRRQSFG 360
GSLFAYSPSG AHSMLPSPKL PVTPLGLAAS TNGSSITPAP KIKKEEDSAI PITVPGRLPV 420
SLAGHPVVAA QAAAVQAAAA QAAVAAQAAA LEQLREKLES TEPPEKKMAL VADEQQRLMQ 480
RAVQQSFLAM TAQLPMNIRI NSQASESRQD SAVSLTSANG SNSISMSVEM NGIVYTGVLF 540
AQPPPPTAPS APGKGGVSSI GTNTTTGSRT GASGSTVSGG QVGLPGVSTP TMSSTSNNSL 600
P 601
|
FASTA
(Canonical) |
>LipidDB-10090-01278|Q62431
MKLQAVMETLIQRQQRARQELEARQAPPPPPPEPTGVRARTTMTDEDREPENARMHRTQM
AALAAMRAAAAGLGHPSSPGGSEDGPPISGDEDTAREGTLSSPALHGSVLEGAGHAEGDR
HLMDVGSDDDDTKSKWEEQELEELGEEEEEEEEEDDFEEEEEEEEGLGPPESASLGTAGL
FTRKAPPAQAFRGDGGPRMLSGPERLGPGPAHPSHMASQMPPPDHGDWTFEEQFKQLYEL
DADPKRKEFLDDLFSFMQKRGTPVNRIPIMAKQVLDLFMLYVLVTEKGGLVEVINKKLWR
EITKGLNLPTSITSAAFTLRTQYMKYLYPYECERRGLSSPNELQAAIDSNRREGRRQSFG
GSLFAYSPSGAHSMLPSPKLPVTPLGLAASTNGSSITPAPKIKKEEDSAIPITVPGRLPV
SLAGHPVVAAQAAAVQAAAAQAAVAAQAAALEQLREKLESTEPPEKKMALVADEQQRLMQ
RAVQQSFLAMTAQLPMNIRINSQASESRQDSAVSLTSANGSNSISMSVEMNGIVYTGVLF
AQPPPPTAPSAPGKGGVSSIGTNTTTGSRTGASGSTVSGGQVGLPGVSTPTMSSTSNNSL
P
|
Gene Ontology |
GO:0005794; C:Golgi apparatus; IEA:Ensembl GO:0045121; C:membrane raft; IEA:Ensembl GO:0005730; C:nucleolus; IEA:Ensembl GO:0005634; C:nucleus; IDA:MGI GO:0003682; F:chromatin binding; IDA:MGI GO:0003677; F:DNA binding; IDA:MGI GO:0042803; F:protein homodimerization activity; IPI:MGI GO:0000977; F:RNA polymerase II regulatory region sequence-specific DNA binding; IDA:NTNU_SB GO:0001228; F:RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription; IDA:NTNU_SB GO:0003700; F:sequence-specific DNA binding transcription factor activity; IDA:MGI GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IMP:NTNU_SB GO:0006355; P:regulation of transcription, DNA-templated; IDA:MGI |
Interpro |
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Pfam |
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SMART |
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PROSITE |
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PRINTS |
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