LipidDB-10090-01240

Lipid Modification Database

Tag

Content

LipidDB ID

LipidDB-10090-01240

Entry Name

ICAM2_MOUSE

UniProt Accession

P35330; Q9D8Q4;

Theoretical PI

8.1

Molecular Weight

31390.25

Genbank Protein ID

CAA46474.1; CAA46473.1; CAA46473.1; CAA46473.1; BAB25266.1; AAH39128.1; AAH39970.1;

Genbank Nucleotide ID

X65493; X65490; X65491; X65492; AK007801; BC039128; BC039970;

Protein Name

Intercellular adhesion molecule 2

Protein Synonyms/Alias

ICAM-2; Lymphocyte function-associated AG-1 counter-receptor; CD102;

Gene Name

Icam2

Gene Synonyms/Alias

Icam-2;

Created Date

01-FEB-1994

Lipid Modification Sites
Position	Sequence Form	Peptide	References	Modification Type
6	Canonical	**MSSFACWSLSLLI	[1]	S-Palmitoylation

Organism

Mus musculus (Mouse)

NCBI Taxa ID

10090

Reference

[1] Predicted from GPS-Lipid

Functional Description

ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). ICAM2 may play a role in lymphocyte recirculation by blocking LFA-1-dependent cell adhesion. It mediates adhesive interactions important for antigen- specific immune response, NK-cell mediated clearance, lymphocyte recirculation, and other cellular interactions important for immune response and surveillance.

Sequence Annotation

Topological domain: 23 222 Extracellular.
Transmembrane: 223 247 Helical.
Topological domain: 248 277 Cytoplasmic.
Domain: 39 98 Ig-like C2-type 1.
Domain: 127 196 Ig-like C2-type 2.

Protein Length

277 AA.

Protein Sequence
(Canonical)

MSSFACWSLS LLILFYSPGS GEKAFEVYIW SEKQIVEATE SWKINCSTNC AAPDMGGLET  60
PTNKIMLEEH PQGKWKQFLV SNVSKDTVFF CHFTCSGKQH SESLNIRVYQ PPAQVTLKLQ  120
PPRVFVGEDF TIECTVSPVQ PLERLTLSLL RGRETLKNQT FGGAETVPQE ATATFNSTAL  180
KKDGLNFSCQ AELDLRPHGG YIIRSISEYQ ILEVYEPMQD NQMVIIIVVV SILLFLFVTS  240
VLLCFIFGQH WHRRRTGTYG VLAAWRRLPR AFRARPV                           277

FASTA
(Canonical)

>LipidDB-10090-01240|P35330
MSSFACWSLSLLILFYSPGSGEKAFEVYIWSEKQIVEATESWKINCSTNCAAPDMGGLET
PTNKIMLEEHPQGKWKQFLVSNVSKDTVFFCHFTCSGKQHSESLNIRVYQPPAQVTLKLQ
PPRVFVGEDFTIECTVSPVQPLERLTLSLLRGRETLKNQTFGGAETVPQEATATFNSTAL
KKDGLNFSCQAELDLRPHGGYIIRSISEYQILEVYEPMQDNQMVIIIVVVSILLFLFVTS
VLLCFIFGQHWHRRRTGTYGVLAAWRRLPRAFRARPV

Gene Ontology

GO:0071944; C:cell periphery; IDA:MGI
GO:0070062; C:extracellular vesicular exosome; IEA:Ensembl
GO:0005887; C:integral component of plasma membrane; IDA:MGI
GO:0005886; C:plasma membrane; IDA:MGI
GO:0001931; C:uropod; IDA:MGI
GO:0016337; P:single organismal cell-cell adhesion; IEA:InterPro

Interpro

InterPro; IPR015653; ICAM2
InterPro; IPR013768; ICAM_N
InterPro; IPR003987; ICAM_VCAM_N
InterPro; IPR013783; Ig-like_fold

Pfam

Pfam; PF03921; ICAM_N;

SMART

PROSITE

PRINTS

PRINTS; PR01472; ICAMVCAM1;