Lipid Modification Database
Tag Content
LipidDB ID
LipidDB-10090-01205
Entry Name
UniProt Accession
Theoretical PI
6.07
Molecular Weight
150289.4
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
Nephrocystin-3
Protein Synonyms/Alias
Gene Name
Nphp3
Gene Synonyms/Alias
Kiaa2000;
Created Date
05-JUL-2005
 Lipid Modification Sites 
 Position   Sequence Form   Peptide   References   Modification Type 
2
Canonical
******MGTASSLVS
[1]
N-Myristoylation
Organism
Mus musculus (Mouse)
NCBI Taxa ID
10090
Reference
[1] Nakata K, Shiba D, Kobayashi D, Yokoyama T. Targeting of Nphp3 to the primary cilia is controlled by an N-terminal myristoylation site and coiled-coil domains.Cytoskeleton (Hoboken). 2012 Apr;69(4):221-34. doi: 10.1002/cm.21014. Epub 2012Feb 21.[PMID:22328406]
Functional Description
Required for normal ciliary development and function. Inhibits disheveled-1-induced canonical Wnt-signaling activity and may also play a role in the control of non-canonical Wnt signaling that regulates planar cell polarity. Probably acts as a molecular switch between different Wnt signaling pathways. Required for proper convergent extension cell movements.
Sequence Annotation
Protein Length
1325 AA.
Protein Sequence
(Canonical)
MGTASSLVSP TGGEVIEDTY GAGGGEACEI PVEVKPKARL LRSSFRRGAG AGPGSLPRAA  60
GGGGLLGASF KSTGSSVPEL EYAAAEFERL KKEYEIFRVS KNQELLSMGR REAKLDTENK  120
RLRAELQALQ KTYQKILREK EGALEAKYQA MERAVTFEHD RDRVKRQFKI FRETKENEIQ  180
DLLRAKRELE SKLQRLQAQG IQVFDPGESD SDDNCTDVTA AGTQCEYWAS RALGSEHSIG  240
SMIQLPQPFR GPEFAHSSID VEGPFANINR DDWDAAVAGL LQATPLFSHS LWSHPVRCYL  300
IYTDETQPEM ELFLKDHSPK LKRMCETMGY FFLAVYFPLD VENQYLTVRK WEIEKSSLVI  360
LFLHSTLPSF LLEDCEEAFL QNPEGKPGLI YHRLEDGKVT CDSVQQFLDQ VSNLGKTTKA  420
KIIEHSGDPA EGVCKIYVGV EKIIKQDILG LENTDVEEKD GGREDSTPEE DDFGDVLWDI  480
HDEQEQMEAF QQTSSSAHEL GFEKYYQRLD DLVVAPAPIP PLLVSGGPGS GKSLLLSKWI  540
QLQQKHFPNT LILSHFVGRP MSTSSESSLI IKRLTLKLMQ HFWAVSALTL DPAKLLEEFP  600
HWLEKLSARH QGSIIIIIDS IDQVQQVEKH MKWLIDPLPV NVRVIVSVNV ETCPTAWRLW  660
PTLHLDPLSP KDAISIITAE CYSMDVRLSR EQEKMLEQHC RPATTRHALY VTLFSKMMAC  720
AGRGGNVAET LHQCLQCQDT VSLYKLVLHH VRESMPSDRD KEWMTQILCL INVSHNGVSE  780
SELMELYPEM SWLSLTSIVH SLHKMHLLTY SCGLLRFQHL QAWETVRLQY LEDPALVSSY  840
REKLISYFAS QLSQDRVTWR SADELPWLFQ QQGSKQKLHS CLLNLLVAQN LYKRGHFAEL  900
LSYWQFVGKD KGAMATEYFE SLKQYENSEG EENMLCLADL YETLGRFLKD LGLLSQAVVP  960
LQRSLEIRET ALDPDHPRVA QSLHQLAGVY VQWKKFGDAE QLYKQALEIS ENAYGADHPH  1020
AARELEALAT LYHKQNKYEQ AEHFRKKSVI IRQQATRRKG SLYGFALLRR RALQLEELTL  1080
GKDKPENART LNELGVLYFL QNNLETAEQF LKRSLEMRER VLGPDHPDCA QSLNNLAALC  1140
NEKKQYEKAE ELYERALDIR RRALAPDHPS LAYTVKHLAI LYKKTGKVDK AVPLYELAVE  1200
IRQKSFGPKH PSVATALVNL AVLHSQMKKH SEALPLYERA LKIYEDSLGR MHPRVGETLK  1260
NLAVLSYEEG NFEKAAELYK RAMEIKEAET SLLGGKAPSR QSSSGDTFLF KTTHSPNVFL  1320
PQGQS                                                              1325
FASTA
(Canonical)
>LipidDB-10090-01205|Q7TNH6
MGTASSLVSPTGGEVIEDTYGAGGGEACEIPVEVKPKARLLRSSFRRGAGAGPGSLPRAA
GGGGLLGASFKSTGSSVPELEYAAAEFERLKKEYEIFRVSKNQELLSMGRREAKLDTENK
RLRAELQALQKTYQKILREKEGALEAKYQAMERAVTFEHDRDRVKRQFKIFRETKENEIQ
DLLRAKRELESKLQRLQAQGIQVFDPGESDSDDNCTDVTAAGTQCEYWASRALGSEHSIG
SMIQLPQPFRGPEFAHSSIDVEGPFANINRDDWDAAVAGLLQATPLFSHSLWSHPVRCYL
IYTDETQPEMELFLKDHSPKLKRMCETMGYFFLAVYFPLDVENQYLTVRKWEIEKSSLVI
LFLHSTLPSFLLEDCEEAFLQNPEGKPGLIYHRLEDGKVTCDSVQQFLDQVSNLGKTTKA
KIIEHSGDPAEGVCKIYVGVEKIIKQDILGLENTDVEEKDGGREDSTPEEDDFGDVLWDI
HDEQEQMEAFQQTSSSAHELGFEKYYQRLDDLVVAPAPIPPLLVSGGPGSGKSLLLSKWI
QLQQKHFPNTLILSHFVGRPMSTSSESSLIIKRLTLKLMQHFWAVSALTLDPAKLLEEFP
HWLEKLSARHQGSIIIIIDSIDQVQQVEKHMKWLIDPLPVNVRVIVSVNVETCPTAWRLW
PTLHLDPLSPKDAISIITAECYSMDVRLSREQEKMLEQHCRPATTRHALYVTLFSKMMAC
AGRGGNVAETLHQCLQCQDTVSLYKLVLHHVRESMPSDRDKEWMTQILCLINVSHNGVSE
SELMELYPEMSWLSLTSIVHSLHKMHLLTYSCGLLRFQHLQAWETVRLQYLEDPALVSSY
REKLISYFASQLSQDRVTWRSADELPWLFQQQGSKQKLHSCLLNLLVAQNLYKRGHFAEL
LSYWQFVGKDKGAMATEYFESLKQYENSEGEENMLCLADLYETLGRFLKDLGLLSQAVVP
LQRSLEIRETALDPDHPRVAQSLHQLAGVYVQWKKFGDAEQLYKQALEISENAYGADHPH
AARELEALATLYHKQNKYEQAEHFRKKSVIIRQQATRRKGSLYGFALLRRRALQLEELTL
GKDKPENARTLNELGVLYFLQNNLETAEQFLKRSLEMRERVLGPDHPDCAQSLNNLAALC
NEKKQYEKAEELYERALDIRRRALAPDHPSLAYTVKHLAILYKKTGKVDKAVPLYELAVE
IRQKSFGPKHPSVATALVNLAVLHSQMKKHSEALPLYERALKIYEDSLGRMHPRVGETLK
NLAVLSYEEGNFEKAAELYKRAMEIKEAETSLLGGKAPSRQSSSGDTFLFKTTHSPNVFL
PQGQS
Gene Ontology
GO:0097546; C:ciliary base; IDA:MGI
GO:0097543; C:ciliary inversin compartment; IDA:MGI
GO:0005929; C:cilium; ISS:UniProtKB
GO:0072372; C:primary cilium; ISS:UniProtKB
GO:0003283; P:atrial septum development; IEA:Ensembl
GO:0060271; P:cilium morphogenesis; ISS:UniProtKB
GO:0060027; P:convergent extension involved in gastrulation; IEA:Ensembl
GO:0071908; P:determination of intestine left/right asymmetry; IEA:Ensembl
GO:0007368; P:determination of left/right symmetry; IMP:BHF-UCL
GO:0071910; P:determination of liver left/right asymmetry; IEA:Ensembl
GO:0035469; P:determination of pancreatic left/right asymmetry; IEA:Ensembl
GO:0071909; P:determination of stomach left/right asymmetry; IEA:Ensembl
GO:0007163; P:establishment or maintenance of cell polarity; IMP:MGI
GO:0030198; P:extracellular matrix organization; IMP:MGI
GO:0001947; P:heart looping; IEA:Ensembl
GO:0060993; P:kidney morphogenesis; IMP:BHF-UCL
GO:0006629; P:lipid metabolic process; IMP:MGI
GO:0030324; P:lung development; IEA:Ensembl
GO:0048496; P:maintenance of organ identity; IMP:HGNC
GO:0090090; P:negative regulation of canonical Wnt signaling pathway; ISS:UniProtKB
GO:0045494; P:photoreceptor cell maintenance; IEA:Ensembl
GO:0030814; P:regulation of cAMP metabolic process; IMP:MGI
GO:2000095; P:regulation of Wnt signaling pathway, planar cell polarity pathway; ISS:UniProtKB
GO:0072189; P:ureter development; IEA:Ensembl
GO:0016055; P:Wnt signaling pathway; IEA:UniProtKB-KW
Interpro
InterPro; IPR027417; P-loop_NTPase
InterPro; IPR013026; TPR-contain_dom
InterPro; IPR011990; TPR-like_helical_dom
InterPro; IPR019734; TPR_repeat
Pfam
Pfam; PF13176; TPR_7;
SMART
SMART; SM00028; TPR;
PROSITE
PROSITE; PS50005; TPR;
PROSITE; PS50293; TPR_REGION;
PRINTS