Lipid Modification Database
Tag Content
LipidDB ID
LipidDB-10090-01198
Entry Name
UniProt Accession
Theoretical PI
6.16
Molecular Weight
21258.61
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
Cell division control protein 42 homolog
Protein Synonyms/Alias
G25K GTP-binding protein;
Gene Name
Cdc42
Gene Synonyms/Alias
Created Date
13-APR-2004
 Lipid Modification Sites 
 Position   Sequence Form   Peptide   References   Modification Type 
188
Isoform 1
ETQPKRKCCIF****
[1]
S-Palmitoylation
189
Isoform 1
TQPKRKCCIF*****
[1]
S-Palmitoylation
Organism
Mus musculus (Mouse)
NCBI Taxa ID
10090
Reference
[1] Wirth A, Chen-Wacker C, Wu YW, Gorinski N, Filippov MA, Pandey G, PonimaskinE. Dual lipidation of the brain-specific Cdc42 isoform regulates its functionalproperties. Biochem J. 2013 Dec 15;456(3):311-22. doi: 10.1042/BJ20130788. PubMedPMID: 24059268.[PMID:24059268]
Functional Description
Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses. Involved in epithelial cell polarization processes. Regulates the bipolar attachment of spindle microtubules to kinetochores before chromosome congression in metaphase. Plays a role in the extension and maintenance of the formation of thin, actin-rich surface projections called filopodia. Mediates CDC42-dependent cell migration.
Sequence Annotation
Nucleotide-binding: 10 17 GTP.
Nucleotide-binding: 57 61 GTP.
Nucleotide-binding: 115 118 GTP.
Motif: 32 40 Effector region.
Modified residue: 64 64 Phosphotyrosine; by SRC.
Modified residue: 188 188 Cysteine methyl ester.
Protein Length
191 AA.
Protein Sequence
(Isoform 1)
MQTIKCVVVG DGAVGKTCLL ISYTTNKFPS EYVPTVFDNY AVTVMIGGEP YTLGLFDTAG  60
QEDYDRLRPL SYPQTDVFLV CFSVVSPSSF ENVKEKWVPE ITHHCPKTPF LLVGTQIDLR  120
DDPSTIEKLA KNKQKPITPE TAEKLARDLK AVKYVECSAL TQRGLKNVFD EAILAALEPP  180
ETQPKRKCCI F                                                       191
FASTA
(Isoform 1)
>LipidDB-10090-01198|P60766-1
MQTIKCVVVGDGAVGKTCLLISYTTNKFPSEYVPTVFDNYAVTVMIGGEPYTLGLFDTAG
QEDYDRLRPLSYPQTDVFLVCFSVVSPSSFENVKEKWVPEITHHCPKTPFLLVGTQIDLR
DDPSTIEKLAKNKQKPITPETAEKLARDLKAVKYVECSALTQRGLKNVFDEAILAALEPP
ETQPKRKCCIF
Gene Ontology
GO:0045177; C:apical part of cell; IDA:MGI
GO:0071944; C:cell periphery; IDA:MGI
GO:0042995; C:cell projection; IDA:MGI
GO:0005911; C:cell-cell junction; IDA:MGI
GO:0005737; C:cytoplasm; IDA:MGI
GO:0005829; C:cytosol; TAS:Reactome
GO:0070062; C:extracellular vesicular exosome; IEA:Ensembl
GO:0030175; C:filopodium; IEA:Ensembl
GO:0000139; C:Golgi membrane; IEA:Ensembl
GO:0031256; C:leading edge membrane; IDA:MGI
GO:0016020; C:membrane; ISS:UniProtKB
GO:0030496; C:midbody; ISS:UniProtKB
GO:0072686; C:mitotic spindle; ISS:UniProtKB
GO:0043005; C:neuron projection; IEA:Ensembl
GO:0043025; C:neuronal cell body; IEA:Ensembl
GO:0030141; C:secretory granule; IEA:Ensembl
GO:0051233; C:spindle midzone; ISS:UniProtKB
GO:0005525; F:GTP binding; IDA:MGI
GO:0030742; F:GTP-dependent protein binding; IPI:UniProtKB
GO:0003924; F:GTPase activity; IDA:MGI
GO:0019901; F:protein kinase binding; IPI:BHF-UCL
GO:0090135; P:actin filament branching; IEA:Ensembl
GO:0051017; P:actin filament bundle assembly; IMP:MGI
GO:0034332; P:adherens junction organization; IMP:MGI
GO:0060070; P:canonical Wnt signaling pathway; IMP:MGI
GO:0003161; P:cardiac conduction system development; IGI:MGI
GO:0034613; P:cellular protein localization; IMP:MGI
GO:0036336; P:dendritic cell migration; IGI:MGI
GO:0016197; P:endosomal transport; TAS:UniProtKB
GO:0048730; P:epidermis morphogenesis; IMP:MGI
GO:0090136; P:epithelial cell-cell adhesion; IMP:MGI
GO:0060684; P:epithelial-mesenchymal cell signaling; IMP:MGI
GO:0051683; P:establishment of Golgi localization; IEA:Ensembl
GO:0035088; P:establishment or maintenance of apical/basal cell polarity; IMP:MGI
GO:0007163; P:establishment or maintenance of cell polarity; TAS:UniProtKB
GO:0046847; P:filopodium assembly; IDA:MGI
GO:0007030; P:Golgi organization; IEA:Ensembl
GO:0006184; P:GTP catabolic process; IDA:GOC
GO:0031069; P:hair follicle morphogenesis; IMP:MGI
GO:0060789; P:hair follicle placode formation; IMP:MGI
GO:0060047; P:heart contraction; IGI:MGI
GO:0031424; P:keratinization; IMP:MGI
GO:0003334; P:keratinocyte development; IMP:MGI
GO:0035264; P:multicellular organism growth; IMP:MGI
GO:0010629; P:negative regulation of gene expression; IMP:MGI
GO:0031333; P:negative regulation of protein complex assembly; IEA:Ensembl
GO:0048664; P:neuron fate determination; IMP:MGI
GO:0007097; P:nuclear migration; IMP:MGI
GO:0051647; P:nucleus localization; IMP:MGI
GO:0072384; P:organelle transport along microtubule; IEA:Ensembl
GO:0032467; P:positive regulation of cytokinesis; ISS:UniProtKB
GO:0045740; P:positive regulation of DNA replication; IEA:Ensembl
GO:0010628; P:positive regulation of gene expression; IMP:MGI
GO:0071338; P:positive regulation of hair follicle cell proliferation; IMP:MGI
GO:0090316; P:positive regulation of intracellular protein transport; IEA:Ensembl
GO:0046330; P:positive regulation of JNK cascade; IEA:Ensembl
GO:0043410; P:positive regulation of MAPK cascade; IDA:MGI
GO:0048554; P:positive regulation of metalloenzyme activity; IEA:Ensembl
GO:0043525; P:positive regulation of neuron apoptotic process; IEA:Ensembl
GO:0033138; P:positive regulation of peptidyl-serine phosphorylation; IMP:MGI
GO:0043552; P:positive regulation of phosphatidylinositol 3-kinase activity; IMP:MGI
GO:0001934; P:positive regulation of protein phosphorylation; IMP:MGI
GO:0031274; P:positive regulation of pseudopodium assembly; IEA:Ensembl
GO:1900026; P:positive regulation of substrate adhesion-dependent cell spreading; ISS:UniProtKB
GO:0051835; P:positive regulation of synapse structural plasticity; IEA:Ensembl
GO:0051988; P:regulation of attachment of spindle microtubules to kinetochore; ISS:UniProtKB
GO:0051489; P:regulation of filopodium assembly; ISS:UniProtKB
GO:0007088; P:regulation of mitosis; IMP:MGI
GO:0042176; P:regulation of protein catabolic process; IMP:MGI
GO:0043497; P:regulation of protein heterodimerization activity; IDA:MGI
GO:0045859; P:regulation of protein kinase activity; IMP:MGI
GO:0051246; P:regulation of protein metabolic process; IMP:MGI
GO:0031647; P:regulation of protein stability; IMP:MGI
GO:0007266; P:Rho protein signal transduction; TAS:MGI
GO:0016337; P:single organismal cell-cell adhesion; TAS:UniProtKB
GO:0002040; P:sprouting angiogenesis; IEA:Ensembl
GO:0060661; P:submandibular salivary gland formation; IEA:Ensembl
GO:0021762; P:substantia nigra development; IEA:Ensembl
Interpro
InterPro; IPR027417; P-loop_NTPase
InterPro; IPR005225; Small_GTP-bd_dom
InterPro; IPR001806; Small_GTPase
InterPro; IPR003578; Small_GTPase_Rho
Pfam
Pfam; PF00071; Ras;
SMART
SMART; SM00174; RHO;
PROSITE
PROSITE; PS51420; RHO;
PRINTS
PRINTS; PR00449; RASTRNSFRMNG;