Lipid Modification Database
Tag Content
LipidDB ID
LipidDB-10090-01153
Entry Name
UniProt Accession
Theoretical PI
4.72
Molecular Weight
121505.16
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
Guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas
Protein Synonyms/Alias
Adenylate cyclase-stimulating G alpha protein; Extra large alphas protein; XLalphas;
Gene Name
Gnas
Gene Synonyms/Alias
Gnas1;
Created Date
17-OCT-2006
 Lipid Modification Sites 
 Position   Sequence Form   Peptide   References   Modification Type 
6
Canonical
**MGMFNCLHGNNMS
[1]
S-Palmitoylation
Organism
Mus musculus (Mouse)
NCBI Taxa ID
10090
Reference
[1] Predicted from GPS-Lipid
Functional Description
Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The G(s) protein is involved in hormonal regulation of adenylate cyclase: it activates the cyclase in response to beta-adrenergic stimuli. XLas isoforms interact with the same set of receptors as Gnas isoforms.
Sequence Annotation
Nucleotide-binding: 786 793 GTP.
Nucleotide-binding: 937 943 GTP.
Nucleotide-binding: 962 966 GTP.
Nucleotide-binding: 1031 1034 GTP.
Metal binding site: 793 793 Magnesium.
Metal binding site: 943 943 Magnesium.
Binding site: 1105 1105 GTP; via amide nitrogen.
Modified residue: 940 940 ADP-ribosylarginine; by cholera toxin.
Modified residue: 1091 1091 Phosphoserine.
Protein Length
1133 AA.
Protein Sequence
(Canonical)
MGMFNCLHGN NMSGQHDIPP EVGEQPEQEP LEAPGAAAPG AGAGPAEEMA TEPDSEPSNN  60
EPVPDETGSE ISGPPEDSKS DIQSPCQAFE EVRVGGDYSP PPEEAMPFET QQPSLGDFWP  120
TLEQPGPSGT PSGLQAFNPA ILEPGTPTGA SPGLGAYTPP PEEAMPFEFN EPAQGDHSQP  180
PLQVPDLAPG GPEALVPRAL PAEPGNIRFE NAGFREDYSP PPEESVPFQV GGEEFGGDSP  240
PPGLPRVIPQ IGIGGEFPTV AVPSALCLAP AENAPPLWVR GAIDRPFREA VRSPPNFACD  300
SPPMEITRPL LEIGRASIGV DDDTAVNMDS PPIASDGPPI EVSGAPDKSE CAERPPVERE  360
AAEMEGSPTT ATAVEGKVPS PERGDGSSTQ PEAMDAKPAP AAQAVSTGSD AGAPTDSAML  420
TDSQSDAGED GTAPGTPSDL QSDPEELEEA PAVRADPDGG AAPVAPATPA ESESEGSRDP  480
AAEPASEAVP ATTAESASGA APVTQVEPAA AAVSATLAEP AARAAPITPK EPTTRAVPSA  540
RAHPAAGAVP GAPAMSASAR AAAARAAYAG PLVWGARSLS ATPAARASLP ARAAAAARAA  600
SAARAVAAGR SASAAPSRAH LRPPSPEIQV ADPPTPRPPP RPTAWPDKYE RGRSCCRYEA  660
SSGICEIESS SDESEEGATG CFQWLLRRNR RPGLPRSHTV GSNPVRNFFT RAFGSCFGLS  720
ECTRSRSLSP GKAKDPMEER RKQMRKEAIE MREQKRADKK RSKLIDKQLE EEKMDYMCTH  780
RLLLLGAGES GKSTIVKQMR ILHVNGFNGE GGEEDPQAAR SNSDGEKATK VQDIKNNLKE  840
AIETIVAAMS NLVPPVELAN PENQFRVDYI LSVMNVPNFD FPPEFYEHAK ALWEDEGVRA  900
CYERSNEYQL IDCAQYFLDK IDVIKQADYV PSDQDLLRCR VLTSGIFETK FQVDKVNFHM  960
FDVGGQRDER RKWIQCFNDV TAIIFVVASS SYNMVIREDN QTNRLQEALN LFKSIWNNRW  1020
LRTISVILFL NKQDLLAEKV LAGKSKIEDY FPEFARYTTP EDATPEPGED PRVTRAKYFI  1080
RDEFLRISTA SGDGRHYCYP HFTCAVDTEN IRRVFNDCRD IIQRMHLRQY ELL         1133
FASTA
(Canonical)
>LipidDB-10090-01153|Q6R0H7
MGMFNCLHGNNMSGQHDIPPEVGEQPEQEPLEAPGAAAPGAGAGPAEEMATEPDSEPSNN
EPVPDETGSEISGPPEDSKSDIQSPCQAFEEVRVGGDYSPPPEEAMPFETQQPSLGDFWP
TLEQPGPSGTPSGLQAFNPAILEPGTPTGASPGLGAYTPPPEEAMPFEFNEPAQGDHSQP
PLQVPDLAPGGPEALVPRALPAEPGNIRFENAGFREDYSPPPEESVPFQVGGEEFGGDSP
PPGLPRVIPQIGIGGEFPTVAVPSALCLAPAENAPPLWVRGAIDRPFREAVRSPPNFACD
SPPMEITRPLLEIGRASIGVDDDTAVNMDSPPIASDGPPIEVSGAPDKSECAERPPVERE
AAEMEGSPTTATAVEGKVPSPERGDGSSTQPEAMDAKPAPAAQAVSTGSDAGAPTDSAML
TDSQSDAGEDGTAPGTPSDLQSDPEELEEAPAVRADPDGGAAPVAPATPAESESEGSRDP
AAEPASEAVPATTAESASGAAPVTQVEPAAAAVSATLAEPAARAAPITPKEPTTRAVPSA
RAHPAAGAVPGAPAMSASARAAAARAAYAGPLVWGARSLSATPAARASLPARAAAAARAA
SAARAVAAGRSASAAPSRAHLRPPSPEIQVADPPTPRPPPRPTAWPDKYERGRSCCRYEA
SSGICEIESSSDESEEGATGCFQWLLRRNRRPGLPRSHTVGSNPVRNFFTRAFGSCFGLS
ECTRSRSLSPGKAKDPMEERRKQMRKEAIEMREQKRADKKRSKLIDKQLEEEKMDYMCTH
RLLLLGAGESGKSTIVKQMRILHVNGFNGEGGEEDPQAARSNSDGEKATKVQDIKNNLKE
AIETIVAAMSNLVPPVELANPENQFRVDYILSVMNVPNFDFPPEFYEHAKALWEDEGVRA
CYERSNEYQLIDCAQYFLDKIDVIKQADYVPSDQDLLRCRVLTSGIFETKFQVDKVNFHM
FDVGGQRDERRKWIQCFNDVTAIIFVVASSSYNMVIREDNQTNRLQEALNLFKSIWNNRW
LRTISVILFLNKQDLLAEKVLAGKSKIEDYFPEFARYTTPEDATPEPGEDPRVTRAKYFI
RDEFLRISTASGDGRHYCYPHFTCAVDTENIRRVFNDCRDIIQRMHLRQYELL
Gene Ontology
GO:0030425; C:dendrite; IDA:MGI
GO:0070062; C:extracellular vesicular exosome; IEA:Ensembl
GO:0005834; C:heterotrimeric G-protein complex; ISA:MGI
GO:0016020; C:membrane; IDA:MGI
GO:0031698; F:beta-2 adrenergic receptor binding; IBA:RefGenome
GO:0051430; F:corticotropin-releasing hormone receptor 1 binding; IBA:RefGenome
GO:0031748; F:D1 dopamine receptor binding; IBA:RefGenome
GO:0031683; F:G-protein beta/gamma-subunit complex binding; IBA:RefGenome
GO:0005525; F:GTP binding; IEA:UniProtKB-KW
GO:0003924; F:GTPase activity; ISA:MGI
GO:0005159; F:insulin-like growth factor receptor binding; IBA:RefGenome
GO:0035255; F:ionotropic glutamate receptor binding; IBA:RefGenome
GO:0046872; F:metal ion binding; IEA:UniProtKB-KW
GO:0031852; F:mu-type opioid receptor binding; IBA:RefGenome
GO:0004871; F:signal transducer activity; IBA:RefGenome
GO:0007191; P:adenylate cyclase-activating dopamine receptor signaling pathway; IGI:MGI
GO:0007189; P:adenylate cyclase-activating G-protein coupled receptor signaling pathway; IDA:MGI
GO:0051216; P:cartilage development; IMP:MGI
GO:0050890; P:cognition; IEA:Ensembl
GO:0048589; P:developmental growth; IEA:Ensembl
GO:0006306; P:DNA methylation; IMP:MGI
GO:0048701; P:embryonic cranial skeleton morphogenesis; IMP:MGI
GO:0035116; P:embryonic hindlimb morphogenesis; IMP:MGI
GO:0001958; P:endochondral ossification; IMP:MGI
GO:0006112; P:energy reserve metabolic process; IMP:MGI
GO:0007186; P:G-protein coupled receptor signaling pathway; TAS:MGI
GO:0071514; P:genetic imprinting; IMP:MGI
GO:0060789; P:hair follicle placode formation; IEA:Ensembl
GO:0035264; P:multicellular organism growth; IMP:MGI
GO:0070527; P:platelet aggregation; IEA:Ensembl
GO:0045669; P:positive regulation of osteoblast differentiation; IMP:MGI
GO:0045672; P:positive regulation of osteoclast differentiation; IMP:MGI
GO:0040032; P:post-embryonic body morphogenesis; IMP:MGI
GO:0009791; P:post-embryonic development; IMP:MGI
GO:0042493; P:response to drug; IMP:MGI
GO:0007606; P:sensory perception of chemical stimulus; IBA:RefGenome
GO:0001501; P:skeletal system development; IMP:MGI
GO:0043588; P:skin development; IMP:MGI
GO:0001894; P:tissue homeostasis; IMP:MGI
Interpro
InterPro; IPR000367; Gprotein_alpha_S
InterPro; IPR001019; Gprotein_alpha_su
InterPro; IPR011025; GproteinA_insert
InterPro; IPR027417; P-loop_NTPase
Pfam
Pfam; PF00503; G-alpha;
SMART
SMART; SM00275; G_alpha;
PROSITE
PRINTS
PRINTS; PR00318; GPROTEINA;
PRINTS; PR00443; GPROTEINAS;