Lipid Modification Database
Tag Content
LipidDB ID
LipidDB-10090-01121
Entry Name
UniProt Accession
Theoretical PI
9.17
Molecular Weight
19815.08
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
Protein tyrosine phosphatase type IVA 1
Protein Synonyms/Alias
3.1.3.48; Protein-tyrosine phosphatase 4a1; Protein-tyrosine phosphatase of regenerating liver 1; PRL-1;
Gene Name
Ptp4a1
Gene Synonyms/Alias
Prl1;
Created Date
05-JUL-2005
 Lipid Modification Sites 
 Position   Sequence Form   Peptide   References   Modification Type 
170
Canonical
SNGHRNNCCIQ****
[1]
S-Farnesylation
Organism
Mus musculus (Mouse)
NCBI Taxa ID
10090
Reference
[1] Zeng Q, Si X, Horstmann H, Xu Y, Hong W, Pallen CJ. Prenylation-dependentassociation of protein-tyrosine phosphatases PRL-1, -2, and -3 with the plasmamembrane and the early endosome. J Biol Chem. 2000 Jul 14;275(28):21444-52.[PMID:10747914]
Functional Description
Protein tyrosine phosphatase which stimulates progression from G1 into S phase during mitosis. May play a role in the development and maintenance of differentiating epithelial tissues (By similarity).
Sequence Annotation
Domain: 82 148 Tyrosine-protein phosphatase.
Region: 97 132 Interaction with ATF5.
Region: 105 110 Phosphate binding.
Active site: 72 72 Proton donor.
Active site: 104 104 Phosphocysteine intermediate.
Binding site: 110 110 Substrate.
Modified residue: 170 170 Cysteine methyl ester.
Protein Length
173 AA.
Protein Sequence
(Canonical)
MARMNRPAPV EVTYKNMRFL ITHNPTNATL NKFIEELKKY GVTTIVRVCE ATYDTTLVEK  60
EGIHVLDWPF DDGAPPSNQI VDDWLSLVKI KFREEPGCCI AVHCVAGLGR APVLVALALI  120
EGGMKYEDAV QFIRQKRRGA FNSKQLLYLE KYRPKMRLRF KDSNGHRNNC CIQ         173
FASTA
(Canonical)
>LipidDB-10090-01121|Q63739
MARMNRPAPVEVTYKNMRFLITHNPTNATLNKFIEELKKYGVTTIVRVCEATYDTTLVEK
EGIHVLDWPFDDGAPPSNQIVDDWLSLVKIKFREEPGCCIAVHCVAGLGRAPVLVALALI
EGGMKYEDAVQFIRQKRRGAFNSKQLLYLEKYRPKMRLRFKDSNGHRNNCCIQ
Gene Ontology
GO:0009898; C:cytoplasmic side of plasma membrane; IEA:Ensembl
GO:0005856; C:cytoskeleton; IEA:UniProtKB-KW
GO:0005783; C:endoplasmic reticulum; IEA:UniProtKB-KW
GO:0005768; C:endosome; TAS:UniProtKB
GO:0070062; C:extracellular vesicular exosome; IEA:Ensembl
GO:0005634; C:nucleus; IEA:Ensembl
GO:0005886; C:plasma membrane; TAS:UniProtKB
GO:0004727; F:prenylated protein tyrosine phosphatase activity; TAS:UniProtKB
GO:0007049; P:cell cycle; IEA:UniProtKB-KW
GO:0007275; P:multicellular organismal development; IEA:UniProtKB-KW
GO:0030335; P:positive regulation of cell migration; IDA:UniProtKB
Interpro
InterPro; IPR029021; Prot-tyrosine_phosphatase-like
InterPro; IPR000387; Tyr/Dual-sp_Pase
InterPro; IPR000242; Tyr_Pase_rcpt/non-rcpt
Pfam
Pfam; PF00102; Y_phosphatase;
SMART
PROSITE
PROSITE; PS50056; TYR_PHOSPHATASE_2;
PRINTS