LipidDB-10090-01109

Lipid Modification Database

Tag

Content

LipidDB ID

LipidDB-10090-01109

Entry Name

TMX1_MOUSE

UniProt Accession

Q8VBT0; Q3UCI8; Q9CSD5;

Theoretical PI

5.19

Molecular Weight

31395.83

Genbank Protein ID

BAB28680.3; BAC26960.1; BAC34326.1; BAE23223.1; BAE29624.1; BAE31660.1; BAE41816.1; AAH17603.1; AAH21533.1;

Genbank Nucleotide ID

AK013150; AK030429; AK050567; AK137059; AK150511; AK153027; AK170468; BC017603; BC021533;

Protein Name

Thioredoxin-related transmembrane protein 1

Protein Synonyms/Alias

Thioredoxin domain-containing protein 1;

Gene Name

Tmx1

Gene Synonyms/Alias

Txndc; Txndc1;

Created Date

10-MAY-2004

Lipid Modification Sites
Position	Sequence Form	Peptide	References	Modification Type
106	Canonical	ALPSIYHCKDGEFRR	[1]	S-Palmitoylation
205	Canonical	CMIFVADCLCPSKRR	[1]	S-Palmitoylation
207	Canonical	IFVADCLCPSKRRKP	[1]	S-Palmitoylation

Organism

Mus musculus (Mouse)

NCBI Taxa ID

10090

Reference

[1] Predicted from GPS-Lipid

Functional Description

May participate in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyze dithiol-disulfide exchange reactions.

Sequence Annotation

Topological domain: 27 181 Extracellular.
Transmembrane: 182 202 Helical.
Topological domain: 203 278 Cytoplasmic.
Domain: 27 132 Thioredoxin.
Modified residue: 245 245 Phosphoserine.
Modified residue: 278 278 Phosphoserine.

Protein Length

278 AA.

Protein Sequence
(Canonical)

MAHLGRLMVP LAALVLLLWA VPGAHGRRNN VRVLTDENWT SLLEGEWMIE FYAPWCPACQ  60
NLQPEWESFA EWGEDLEVKV AKVDVTEQTG LSGRFIITAL PSIYHCKDGE FRRYVGPRTK  120
KDFINFVSDK EWKNIEPISS WFGPSSVLMT MMSALFQLSV YIRTSHSYFV HDLGIPAWGS  180
YLVFAFATVL SGLLLGLCMI FVADCLCPSK RRKPQQQYAK KTSPEFSQPL KKVEEEQEAD  240
EEDVSEEEAE DREGASKATS QSSIRQRCVG LPSATDTS                          278

FASTA
(Canonical)

>LipidDB-10090-01109|Q8VBT0
MAHLGRLMVPLAALVLLLWAVPGAHGRRNNVRVLTDENWTSLLEGEWMIEFYAPWCPACQ
NLQPEWESFAEWGEDLEVKVAKVDVTEQTGLSGRFIITALPSIYHCKDGEFRRYVGPRTK
KDFINFVSDKEWKNIEPISSWFGPSSVLMTMMSALFQLSVYIRTSHSYFVHDLGIPAWGS
YLVFAFATVLSGLLLGLCMIFVADCLCPSKRRKPQQQYAKKTSPEFSQPLKKVEEEQEAD
EEDVSEEEAEDREGASKATSQSSIRQRCVGLPSATDTS

Gene Ontology

GO:0005783; C:endoplasmic reticulum; IBA:RefGenome
GO:0005789; C:endoplasmic reticulum membrane; IEA:Ensembl
GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW
GO:0005730; C:nucleolus; IEA:Ensembl
GO:0015036; F:disulfide oxidoreductase activity; IEA:Ensembl
GO:0003756; F:protein disulfide isomerase activity; IBA:RefGenome
GO:0045454; P:cell redox homeostasis; IEA:InterPro
GO:0006457; P:protein folding; IBA:RefGenome
GO:0034976; P:response to endoplasmic reticulum stress; IBA:RefGenome

Interpro

InterPro; IPR012336; Thioredoxin-like_fold
InterPro; IPR017937; Thioredoxin_CS
InterPro; IPR013766; Thioredoxin_domain

Pfam

Pfam; PF00085; Thioredoxin;

SMART

PROSITE

PROSITE; PS00194; THIOREDOXIN_1;
PROSITE; PS51352; THIOREDOXIN_2;

PRINTS