LipidDB ID

LipidDB-10090-01018

Entry Name

UniProt Accession

Q80WJ7; B2RSG8; Q05CM0; Q3U9F8; Q3UAQ8; Q8BN67; Q8CBT9; Q8CDL0; Q8CGI7; Q9D052;

Theoretical PI

9.34

Molecular Weight

63846.0

Genbank Protein ID

AAS68097.1; AAP30790.1; BAB27854.1; BAC26673.1; BAC29022.1; BAE30256.1; BAE30709.1; AAH23115.1; AAH36994.1; AAI38859.1; AAI38860.1;

Genbank Nucleotide ID

AY553638; AF501309; AK011808; AK029915; AK035302; AK151269; AK151810; BC023115; BC036994; BC138858; BC138859;

Protein Name

Protein LYRIC

Protein Synonyms/Alias

3D3/LYRIC; Lysine-rich CEACAM1 co-isolated protein; Metadherin; Metastasis adhesion protein;

Gene Name

Mtdh

Gene Synonyms/Alias

Lyric;

Created Date

21-DEC-2004

Organism

Mus musculus (Mouse)

NCBI Taxa ID

10090

Reference

[1] Predicted from GPS-Lipid

Functional Description

Downregulates SLC1A2/EAAT2 promoter activity when expressed ectopically. Activates the nuclear factor kappa-B (NF- kappa-B) transcription factor. Promotes anchorage-independent growth of immortalized melanocytes and astrocytes which is a key component in tumor cell expansion. Promotes lung metastasis and also has an effect on bone and brain metastasis, possibly by enhancing the seeding of tumor cells to the target organ endothelium. Induces chemoresistance (By similarity).

Sequence Annotation

Topological domain: 1 48 Lumenal.
Transmembrane: 49 69 Helical.
Topological domain: 70 579 Cytoplasmic.
Region: 1 71 Activation of NF-kappa-B.
Region: 72 168 Interaction with BCCIP.
Region: 100 204 Interaction with RELA.
Region: 378 440 Lung-homing for mammary tumors.
Modified residue: 263 263 N6-acetyllysine.
Modified residue: 297 297 Phosphoserine.
Modified residue: 303 303 Phosphoserine.
Modified residue: 308 308 Phosphoserine.
Modified residue: 341 341 Phosphoserine.
Modified residue: 366 366 Phosphoserine.
Modified residue: 412 412 Phosphoserine.
Modified residue: 423 423 Phosphoserine.
Modified residue: 565 565 Phosphoserine.

Protein Length

579 AA.

Protein Sequence
(Canonical)

FASTA
(Canonical)

Gene Ontology

GO:0016324; C:apical plasma membrane; IEA:Ensembl
GO:0005783; C:endoplasmic reticulum; IDA:UniProtKB
GO:0005789; C:endoplasmic reticulum membrane; IDA:UniProtKB
GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW
GO:0046581; C:intercellular canaliculus; IEA:Ensembl
GO:0016604; C:nuclear body; IEA:Ensembl
GO:0005730; C:nucleolus; IDA:UniProtKB
GO:0048471; C:perinuclear region of cytoplasm; IDA:UniProtKB
GO:0005923; C:tight junction; IEA:UniProtKB-KW
GO:0003725; F:double-stranded RNA binding; ISO:MGI
GO:0051059; F:NF-kappaB binding; ISS:UniProtKB
GO:0044822; F:poly(A) RNA binding; IEA:Ensembl
GO:0003713; F:transcription coactivator activity; IEA:Ensembl
GO:0031663; P:lipopolysaccharide-mediated signaling pathway; IEA:Ensembl
GO:0043066; P:negative regulation of apoptotic process; IEA:Ensembl
GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; ISS:UniProtKB
GO:0045766; P:positive regulation of angiogenesis; IEA:Ensembl
GO:0010508; P:positive regulation of autophagy; IEA:Ensembl
GO:0043123; P:positive regulation of I-kappaB kinase/NF-kappaB signaling; IEA:Ensembl
GO:0051092; P:positive regulation of NF-kappaB transcription factor activity; ISS:UniProtKB
GO:0051897; P:positive regulation of protein kinase B signaling; IEA:Ensembl
GO:0070830; P:tight junction assembly; IEA:Ensembl

Interpro

Pfam

SMART

PROSITE

PRINTS