LipidDB ID

LipidDB-10090-00978

Entry Name

UniProt Accession

Q62108; Q5NCV5; Q5NCV6; Q5NCV7; Q91WJ1;

Theoretical PI

5.56

Molecular Weight

80472.32

Genbank Protein ID

BAA09297.1; CAI35168.1; CAI35169.1; CAI35170.1; AAH14807.1;

Genbank Nucleotide ID

D50621; AL596185; AL596185; AL596185; BC014807;

Protein Name

Disks large homolog 4

Protein Synonyms/Alias

Postsynaptic density protein 95; PSD-95; Synapse-associated protein 90; SAP-90; SAP90;

Gene Name

Dlg4

Gene Synonyms/Alias

Dlgh4; Psd95;

Created Date

01-NOV-1997

Organism

Mus musculus (Mouse)

NCBI Taxa ID

10090

Reference

[1] Topinka JR, Bredt DS. N-terminal palmitoylation of PSD-95 regulatesassociation with cell membranes and interaction with K+ channel Kv1.4. Neuron.1998 Jan;20(1):125-34.[PMID:9459448]
[2] Wong W, Schlichter LC. Differential recruitment of Kv1.4 and Kv4.2 to lipidrafts by PSD-95. J Biol Chem. 2004 Jan 2;279(1):444-52. Epub 2003 Oct 14.[PMID:14559911]

Functional Description

Interacts with the cytoplasmic tail of NMDA receptor subunits and shaker-type potassium channels. Required for synaptic plasticity associated with NMDA receptor signaling. Overexpression or depletion of DLG4 changes the ratio of excitatory to inhibitory synapses in hippocampal neurons. May reduce the amplitude of ASIC3 acid-evoked currents by retaining the channel intracellularly. May regulate the intracellular trafficking of ADR1B.

Sequence Annotation

Domain: 65 151 PDZ 1.
Domain: 160 246 PDZ 2.
Domain: 313 393 PDZ 3.
Domain: 428 498 SH3.
Domain: 534 709 Guanylate kinase-like.
Modified residue: 142 142 Phosphoserine.
Modified residue: 240 240 Phosphotyrosine.
Modified residue: 580 580 Phosphotyrosine.
Modified residue: 715 715 Phosphotyrosine.

Protein Length

724 AA.

Protein Sequence
(Canonical)

FASTA
(Canonical)

Gene Ontology

GO:0032281; C:alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex; IDA:MGI
GO:0030054; C:cell junction; IDA:MGI
GO:0044300; C:cerebellar mossy fiber; IDA:MGI
GO:0030863; C:cortical cytoskeleton; IEA:Ensembl
GO:0005737; C:cytoplasm; IDA:MGI
GO:0030425; C:dendrite; IDA:MGI
GO:0032839; C:dendrite cytoplasm; ISS:BHF-UCL
GO:0043197; C:dendritic spine; IDA:ParkinsonsUK-UCL
GO:0005783; C:endoplasmic reticulum; IDA:MGI
GO:0060076; C:excitatory synapse; IDA:BHF-UCL
GO:0031234; C:extrinsic component of cytoplasmic side of plasma membrane; IDA:MGI
GO:0044224; C:juxtaparanode region of axon; IDA:MGI
GO:0016020; C:membrane; IDA:MGI
GO:0044306; C:neuron projection terminus; IDA:MGI
GO:0044309; C:neuron spine; IDA:BHF-UCL
GO:0097481; C:neuronal postsynaptic density; ISS:BHF-UCL
GO:0005886; C:plasma membrane; IDA:MGI
GO:0014069; C:postsynaptic density; ISS:UniProtKB
GO:0045211; C:postsynaptic membrane; IEA:UniProtKB-KW
GO:0045202; C:synapse; IDA:MGI
GO:0097060; C:synaptic membrane; IDA:MGI
GO:0008021; C:synaptic vesicle; IDA:MGI
GO:0033130; F:acetylcholine receptor binding; ISS:BHF-UCL
GO:0031697; F:beta-1 adrenergic receptor binding; ISS:BHF-UCL
GO:0031748; F:D1 dopamine receptor binding; ISS:BHF-UCL
GO:0035255; F:ionotropic glutamate receptor binding; IPI:BHF-UCL
GO:0042043; F:neurexin family protein binding; NAS:UniProtKB
GO:0031812; F:P2Y1 nucleotide receptor binding; ISS:BHF-UCL
GO:0030165; F:PDZ domain binding; ISS:BHF-UCL
GO:0008022; F:protein C-terminus binding; ISS:BHF-UCL
GO:0032403; F:protein complex binding; ISS:BHF-UCL
GO:0019903; F:protein phosphatase binding; ISS:BHF-UCL
GO:0097110; F:scaffold protein binding; IPI:BHF-UCL
GO:0005198; F:structural molecule activity; NAS:UniProtKB
GO:0097113; P:alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor clustering; ISS:BHF-UCL
GO:0060997; P:dendritic spine morphogenesis; IDA:BHF-UCL
GO:0045184; P:establishment of protein localization; ISS:BHF-UCL
GO:0007626; P:locomotory behavior; NAS:UniProtKB
GO:0035641; P:locomotory exploration behavior; IMP:BHF-UCL
GO:0002091; P:negative regulation of receptor internalization; ISS:BHF-UCL
GO:0050885; P:neuromuscular process controlling balance; IMP:BHF-UCL
GO:0007204; P:positive regulation of cytosolic calcium ion concentration; ISS:BHF-UCL
GO:2000463; P:positive regulation of excitatory postsynaptic membrane potential; ISS:BHF-UCL
GO:0050806; P:positive regulation of synaptic transmission; ISS:BHF-UCL
GO:0006461; P:protein complex assembly; ISS:BHF-UCL
GO:0035418; P:protein localization to synapse; ISS:BHF-UCL
GO:0097120; P:receptor localization to synapse; ISS:BHF-UCL
GO:2000821; P:regulation of grooming behavior; IMP:BHF-UCL
GO:0048169; P:regulation of long-term neuronal synaptic plasticity; IGI:MGI
GO:2000310; P:regulation of N-methyl-D-aspartate selective glutamate receptor activity; ISS:BHF-UCL
GO:0048168; P:regulation of neuronal synaptic plasticity; NAS:UniProtKB
GO:0042220; P:response to cocaine; NAS:UniProtKB
GO:0035176; P:social behavior; IMP:BHF-UCL
GO:0016188; P:synaptic vesicle maturation; IDA:MGI
GO:0071625; P:vocalization behavior; IMP:BHF-UCL

Interpro

InterPro; IPR016313; DLG1
InterPro; IPR008145; GK/Ca_channel_bsu
InterPro; IPR008144; Guanylate_kin-like
InterPro; IPR020590; Guanylate_kinase_CS
InterPro; IPR019590; MAGUK_PEST_N
InterPro; IPR027417; P-loop_NTPase
InterPro; IPR001478; PDZ
InterPro; IPR019583; PDZ_assoc
InterPro; IPR011511; SH3_2
InterPro; IPR001452; SH3_domain

Pfam

Pfam; PF00625; Guanylate_kin;
Pfam; PF10608; MAGUK_N_PEST;
Pfam; PF00595; PDZ;
Pfam; PF10600; PDZ_assoc;
Pfam; PF07653; SH3_2;

SMART

SMART; SM00072; GuKc;
SMART; SM00228; PDZ;
SMART; SM00326; SH3;

PROSITE

PROSITE; PS00856; GUANYLATE_KINASE_1;
PROSITE; PS50052; GUANYLATE_KINASE_2;
PROSITE; PS50106; PDZ;
PROSITE; PS50002; SH3;

PRINTS