LipidDB ID

LipidDB-10090-00970

Entry Name

UniProt Accession

P49769; Q91WK6; Q9JLP9;

Theoretical PI

5.23

Molecular Weight

52639.83

Genbank Protein ID

AAC42094.1; AAB72049.1; AAF73153.1; AAH14744.1; AAH30409.1; AAH71233.1;

Genbank Nucleotide ID

L42177; AF007560; AF149111; BC014744; BC030409; BC071233;

Protein Name

Presenilin-1 CTF12

Protein Synonyms/Alias

PS-1; 3.4.23.-; Protein S182; PS1-CTF12;

Gene Name

Psen1

Gene Synonyms/Alias

Ad3h; Psnl1;

Created Date

01-OCT-1996

Organism

Mus musculus (Mouse)

NCBI Taxa ID

10090

Reference

[1] Predicted from GPS-Lipid

Functional Description

Probable catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (beta-amyloid precursor protein). Requires the other members of the gamma-secretase complex to have a protease activity. May play a role in intracellular signaling and gene expression or in linking chromatin to the nuclear membrane. Stimulates cell-cell adhesion though its association with the E-cadherin/catenin complex. Under conditions of apoptosis or calcium influx, cleaves E-cadherin promoting the disassembly of the E-cadherin/catenin complex and increasing the pool of cytoplasmic beta-catenin, thus negatively regulating Wnt signaling. May also play a role in hematopoiesis (By similarity).

Sequence Annotation

Topological domain: 1 82 Cytoplasmic.
Transmembrane: 83 103 Helical.
Topological domain: 104 132 Lumenal.
Transmembrane: 133 153 Helical.
Topological domain: 154 160 Cytoplasmic.
Transmembrane: 161 181 Helical.
Topological domain: 182 194 Lumenal.
Transmembrane: 195 215 Helical.
Topological domain: 216 220 Cytoplasmic.
Transmembrane: 221 241 Helical.
Topological domain: 242 243 Lumenal.
Transmembrane: 244 264 Helical.
Topological domain: 265 380 Cytoplasmic.
Transmembrane: 381 401 Helical.
Topological domain: 402 407 Lumenal.
Transmembrane: 408 428 Helical.
Topological domain: 429 432 Cytoplasmic.
Topological domain: 454 467 Cytoplasmic.
Region: 322 450 Required for interaction with CTNNB1.
Region: 372 399 Required for interaction with CTNND2.
Region: 464 467 Interaction with MTCH1.
Motif: 433 435 PAL.
Active site: 257 257
Active site: 385 385
Functional site: 291 292 Cleavage; alternate.
Functional site: 292 293 Cleavage; alternate.
Functional site: 298 299 Cleavage.
Functional site: 345 346 Cleavage; by caspase.
Modified residue: 329 329 Phosphoserine.
Modified residue: 346 346 Phosphoserine; by PKC.
Modified residue: 367 367 Phosphoserine.
Modified residue: 370 370 Phosphothreonine.
Modified residue: 371 371 Phosphoserine.

Protein Length

467 AA.

Protein Sequence
(Canonical)

FASTA
(Canonical)

Gene Ontology

GO:0016324; C:apical plasma membrane; IBA:RefGenome
GO:0030424; C:axon; IDA:MGI
GO:0005938; C:cell cortex; IBA:RefGenome
GO:0009986; C:cell surface; IBA:RefGenome
GO:0005813; C:centrosome; IEA:Ensembl
GO:0035253; C:ciliary rootlet; IDA:MGI
GO:0031410; C:cytoplasmic vesicle; IDA:MGI
GO:0030425; C:dendrite; IDA:MGI
GO:0043198; C:dendritic shaft; IDA:MGI
GO:0005783; C:endoplasmic reticulum; ISS:UniProtKB
GO:0070765; C:gamma-secretase complex; IEA:Ensembl
GO:0005794; C:Golgi apparatus; ISS:UniProtKB
GO:0030426; C:growth cone; IDA:MGI
GO:0005887; C:integral component of plasma membrane; ISS:UniProtKB
GO:0005622; C:intracellular; IDA:MGI
GO:0000776; C:kinetochore; IEA:Ensembl
GO:0005765; C:lysosomal membrane; IBA:RefGenome
GO:0016020; C:membrane; IDA:MGI
GO:0045121; C:membrane raft; IBA:RefGenome
GO:0043227; C:membrane-bounded organelle; IDA:MGI
GO:0005743; C:mitochondrial inner membrane; IBA:RefGenome
GO:0005739; C:mitochondrion; ISS:UniProtKB
GO:0031594; C:neuromuscular junction; IBA:RefGenome
GO:0043025; C:neuronal cell body; IDA:MGI
GO:0005640; C:nuclear outer membrane; IEA:Ensembl
GO:0005634; C:nucleus; IDA:MGI
GO:0048471; C:perinuclear region of cytoplasm; IBA:RefGenome
GO:0005886; C:plasma membrane; IDA:MGI
GO:0005791; C:rough endoplasmic reticulum; IEA:Ensembl
GO:0005790; C:smooth endoplasmic reticulum; IEA:Ensembl
GO:0030018; C:Z disc; IBA:RefGenome
GO:0004190; F:aspartic-type endopeptidase activity; IEA:InterPro
GO:0008013; F:beta-catenin binding; IBA:RefGenome
GO:0045296; F:cadherin binding; IPI:MGI
GO:0005262; F:calcium channel activity; IEA:Ensembl
GO:0004175; F:endopeptidase activity; IMP:MGI
GO:0000186; P:activation of MAPKK activity; IMP:MGI
GO:0042987; P:amyloid precursor protein catabolic process; IMP:MGI
GO:0042640; P:anagen; IGI:MGI
GO:0000045; P:autophagic vacuole assembly; IMP:MGI
GO:0006914; P:autophagy; IMP:MGI
GO:0034205; P:beta-amyloid formation; IMP:MGI
GO:0050435; P:beta-amyloid metabolic process; IMP:MGI
GO:0001568; P:blood vessel development; IMP:MGI
GO:0007420; P:brain development; IMP:MGI
GO:0048854; P:brain morphogenesis; IGI:MGI
GO:0021870; P:Cajal-Retzius cell differentiation; IMP:MGI
GO:0006816; P:calcium ion transport; IBA:RefGenome
GO:0060070; P:canonical Wnt signaling pathway; IBA:RefGenome
GO:0001708; P:cell fate specification; IGI:MGI
GO:0006874; P:cellular calcium ion homeostasis; IMP:MGI
GO:0044267; P:cellular protein metabolic process; IDA:MGI
GO:0006974; P:cellular response to DNA damage stimulus; IMP:MGI
GO:0021795; P:cerebral cortex cell migration; IMP:MGI
GO:0021987; P:cerebral cortex development; IMP:MGI
GO:0015871; P:choline transport; IMP:MGI
GO:0021904; P:dorsal/ventral neural tube patterning; IGI:MGI
GO:0030326; P:embryonic limb morphogenesis; IGI:MGI
GO:0032469; P:endoplasmic reticulum calcium ion homeostasis; IMP:MGI
GO:0050673; P:epithelial cell proliferation; IGI:MGI
GO:0030900; P:forebrain development; IGI:MGI
GO:0007507; P:heart development; IMP:MGI
GO:0001947; P:heart looping; IGI:MGI
GO:0002244; P:hematopoietic progenitor cell differentiation; IGI:MGI
GO:0035556; P:intracellular signal transduction; IEA:InterPro
GO:0015813; P:L-glutamate transport; IMP:MGI
GO:0007611; P:learning or memory; IGI:MGI
GO:0040011; P:locomotion; IGI:MGI
GO:0006509; P:membrane protein ectodomain proteolysis; ISS:UniProtKB
GO:0007613; P:memory; IMP:MGI
GO:0006839; P:mitochondrial transport; IMP:MGI
GO:0043011; P:myeloid dendritic cell differentiation; IMP:MGI
GO:0002573; P:myeloid leukocyte differentiation; IGI:MGI
GO:0043066; P:negative regulation of apoptotic process; IDA:MGI
GO:2001234; P:negative regulation of apoptotic signaling pathway; IGI:MGI
GO:0050771; P:negative regulation of axonogenesis; IMP:MGI
GO:0007175; P:negative regulation of epidermal growth factor-activated receptor activity; IMP:BHF-UCL
GO:0043524; P:negative regulation of neuron apoptotic process; IEA:Ensembl
GO:0006469; P:negative regulation of protein kinase activity; IMP:MGI
GO:0001933; P:negative regulation of protein phosphorylation; IGI:MGI
GO:2000059; P:negative regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process; IMP:BHF-UCL
GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; IMP:BHF-UCL
GO:0051444; P:negative regulation of ubiquitin-protein transferase activity; IMP:BHF-UCL
GO:0022008; P:neurogenesis; IMP:MGI
GO:0051402; P:neuron apoptotic process; IGI:MGI
GO:0048666; P:neuron development; IMP:MGI
GO:0030182; P:neuron differentiation; IMP:MGI
GO:0001764; P:neuron migration; IMP:MGI
GO:0007220; P:Notch receptor processing; IMP:MGI
GO:0007219; P:Notch signaling pathway; IMP:MGI
GO:0043065; P:positive regulation of apoptotic process; IGI:MGI
GO:0043085; P:positive regulation of catalytic activity; ISS:UniProtKB
GO:0050820; P:positive regulation of coagulation; IMP:MGI
GO:0043406; P:positive regulation of MAP kinase activity; IMP:MGI
GO:0032436; P:positive regulation of proteasomal ubiquitin-dependent protein catabolic process; IMP:BHF-UCL
GO:0045860; P:positive regulation of protein kinase activity; IDA:MGI
GO:0001934; P:positive regulation of protein phosphorylation; IMP:MGI
GO:0001921; P:positive regulation of receptor recycling; IMP:BHF-UCL
GO:0009791; P:post-embryonic development; IMP:MGI
GO:0006486; P:protein glycosylation; IMP:MGI
GO:0051604; P:protein maturation; IGI:MGI
GO:0016485; P:protein processing; ISS:UniProtKB
GO:0015031; P:protein transport; IGI:MGI
GO:0007176; P:regulation of epidermal growth factor-activated receptor activity; IGI:MGI
GO:0043393; P:regulation of protein binding; IGI:MGI
GO:0060075; P:regulation of resting membrane potential; IMP:MGI
GO:0048167; P:regulation of synaptic plasticity; IMP:MGI
GO:0051966; P:regulation of synaptic transmission, glutamatergic; IMP:MGI
GO:0006979; P:response to oxidative stress; IMP:MGI
GO:0035282; P:segmentation; IMP:MGI
GO:0016337; P:single organismal cell-cell adhesion; ISO:MGI
GO:0048705; P:skeletal system morphogenesis; IMP:MGI
GO:0043589; P:skin morphogenesis; IMP:BHF-UCL
GO:0051563; P:smooth endoplasmic reticulum calcium ion homeostasis; IGI:MGI
GO:0001756; P:somitogenesis; IMP:MGI
GO:0016080; P:synaptic vesicle targeting; IMP:MGI
GO:0002286; P:T cell activation involved in immune response; IGI:MGI
GO:0050852; P:T cell receptor signaling pathway; IGI:MGI
GO:0048538; P:thymus development; IMP:MGI

Interpro

InterPro; IPR002031; Pept_A22A_PS1
InterPro; IPR001108; Peptidase_A22A
InterPro; IPR006639; Preselin/SPP

Pfam

Pfam; PF01080; Presenilin;

SMART

SMART; SM00730; PSN;

PROSITE

PRINTS

PRINTS; PR01072; PRESENILIN;
PRINTS; PR01073; PRESENILIN1;