| Tag |
Content |
LipidDB ID |
LipidDB-10090-00930 |
Entry Name |
|
UniProt Accession |
|
Theoretical PI |
7.33 |
Molecular Weight |
38241.41 |
Genbank Protein ID |
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Genbank Nucleotide ID |
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Protein Name |
Sphingolipid delta(4)-desaturase DES1 |
Protein Synonyms/Alias |
1.14.-.-; Degenerative spermatocyte homolog 1; |
Gene Name |
Degs1 |
Gene Synonyms/Alias |
Degs; Des1; Mdes; |
Created Date |
04-DEC-2007 |
| Lipid Modification Sites |
|---|
| Position |
Sequence Form |
Peptide |
References |
Modification Type |
2 | Canonical | ******MGSRVSREE | [1][2] | N-Myristoylation |
|
Organism |
Mus musculus (Mouse) |
NCBI Taxa ID |
10090 |
Reference |
[1] Beauchamp E, Goenaga D, Le Bloc'h J, Catheline D, Legrand P, Rioux V. Myristicacid increases the activity of dihydroceramide Delta4-desaturase 1 through itsN-terminal myristoylation. Biochimie. 2007 Dec;89(12):1553-61. Epub 2007 Jul 15.[ PMID:17716801]
[2] Beauchamp E, Tekpli X, Marteil G, Lagadic-Gossmann D, Legrand P, Rioux V.N-Myristoylation targets dihydroceramide Delta4-desaturase 1 to mitochondria:partial involvement in the apoptotic effect of myristic acid. Biochimie. 2009Nov-Dec;91(11-12):1411-9. doi: 10.1016/j.biochi.2009.07.014. Epub 2009 Jul 30.[ PMID:19647031]
|
Functional Description |
Has sphingolipid-delta-4-desaturase activity. Converts D-erythro-sphinganine to D-erythro-sphingosine (E-sphing-4-enine). |
Sequence Annotation |
Transmembrane: 41 61 Helical.
Transmembrane: 68 88 Helical.
Transmembrane: 104 124 Helical.
Transmembrane: 152 172 Helical.
Transmembrane: 184 204 Helical.
Transmembrane: 209 229 Helical.
Modified residue: 307 307 Phosphoserine.
|
Protein Length |
323 AA. |
Protein Sequence
(Canonical) |
MGSRVSREEF EWVYTDQPHA ARRKEILAKY PEIKSLMKPD HNLIWIVAMM LLVQLASFYL 60
VKDLDWKWVI FWSYVFGSCL NHSMTLAIHE ISHNFPFGHH KALWNRWFGM FANLSLGVPY 120
SISFKRYHMD HHRYLGADKI DVDIPTDFEG WFFCTTFRKF VWVILQPLFY AFRPLFINPK 180
PITYLEIINT VIQITFDIII YYVFGVKSLV YMLAATLLGL GLHPISGHFI AEHYMFLKGH 240
ETYSYYGPLN LLTFNVGYHN EHHDFPNVPG KNLPMVRKIA SEYYDDLPHY NSWIKVLYDF 300
VTDDTISPYS RMKRPPKGNE ILE 323
|
FASTA
(Canonical) |
>LipidDB-10090-00930|O09005
MGSRVSREEFEWVYTDQPHAARRKEILAKYPEIKSLMKPDHNLIWIVAMMLLVQLASFYL
VKDLDWKWVIFWSYVFGSCLNHSMTLAIHEISHNFPFGHHKALWNRWFGMFANLSLGVPY
SISFKRYHMDHHRYLGADKIDVDIPTDFEGWFFCTTFRKFVWVILQPLFYAFRPLFINPK
PITYLEIINTVIQITFDIIIYYVFGVKSLVYMLAATLLGLGLHPISGHFIAEHYMFLKGH
ETYSYYGPLNLLTFNVGYHNEHHDFPNVPGKNLPMVRKIASEYYDDLPHYNSWIKVLYDF
VTDDTISPYSRMKRPPKGNEILE
|
Gene Ontology |
GO:0005783; C:endoplasmic reticulum; IEA:UniProtKB-KW GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW GO:0005739; C:mitochondrion; IEA:UniProtKB-KW GO:0016705; F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen; IEA:InterPro GO:0006633; P:fatty acid biosynthetic process; IEA:UniProtKB-KW GO:0030148; P:sphingolipid biosynthetic process; IEA:InterPro |
Interpro |
InterPro; IPR005804; Fatty_acid_desaturase-1 InterPro; IPR011388; Sphingolipid_d4-desaturase InterPro; IPR013866; Sphingolipid_d4-desaturase_N |
Pfam |
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SMART |
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PROSITE |
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PRINTS |
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