Lipid Modification Database
Tag Content
LipidDB ID
LipidDB-10090-00908
Entry Name
UniProt Accession
Theoretical PI
5.91
Molecular Weight
28476.26
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
Src-like-adapter 2
Protein Synonyms/Alias
Src-like adapter protein 2; SLAP-2;
Gene Name
Sla2
Gene Synonyms/Alias
Created Date
23-APR-2003
 Lipid Modification Sites 
 Position   Sequence Form   Peptide   References   Modification Type 
2
Canonical
******MGSLSSRGK
[1][2]
N-Myristoylation
Organism
Mus musculus (Mouse)
NCBI Taxa ID
10090
Reference
[1] Pandey A, Ibarrola N, Kratchmarova I, Fernandez MM, Constantinescu SN, OharaO, Sawasdikosol S, Lodish HF, Mann M. A novel Src homology 2 domain-containingmolecule, Src-like adapter protein-2 (SLAP-2), which negatively regulates T cell receptor signaling. J Biol Chem. 2002 May 24;277(21):19131-8. Epub 2002 Mar 12.[PMID:11891219]
[2] Loreto MP, Berry DM, McGlade CJ. Functional cooperation between c-Cbl andSrc-like adaptor protein 2 in the negative regulation of T-cell receptorsignaling. Mol Cell Biol. 2002 Jun;22(12):4241-55.[PMID:12024036]
Functional Description
Adapter protein, which negatively regulates T-cell receptor (TCR) signaling. Inhibits T-cell antigen-receptor induced activation of nuclear factor of activated T-cells. May act by linking signaling proteins such as ZAP70 with CBL, leading to a CBL dependent degradation of signaling proteins.
Sequence Annotation
Domain: 31 91 SH3.
Domain: 93 190 SH2.
Region: 190 259 SLA C-terminal.
Protein Length
259 AA.
Protein Sequence
(Canonical)
MGSLSSRGKT SSPSPSSSGP DQEPVSMQPE RHKVTAVALG SFPAGEQARL SLRLGEPLTI  60
ISEDGDWWTV QSEVSGREYH MPSVYVAKVA HGWLYEGLSR EKAEELLLLP GNPGGAFLIR  120
ESQTRRGCYS LSVRLSRPAS WDRIRHYRIQ RLDNGWLYIS PRLTFPSLHA LVEHYSELAD  180
GICCPLREPC VLQKLGPLPG KDTPPPVTVP TSSLNWKKLD RSLLFLEAPA SGEASLLSEG  240
LRESLSSYIS LAEDPLDDA                                               259
FASTA
(Canonical)
>LipidDB-10090-00908|Q8R4L0
MGSLSSRGKTSSPSPSSSGPDQEPVSMQPERHKVTAVALGSFPAGEQARLSLRLGEPLTI
ISEDGDWWTVQSEVSGREYHMPSVYVAKVAHGWLYEGLSREKAEELLLLPGNPGGAFLIR
ESQTRRGCYSLSVRLSRPASWDRIRHYRIQRLDNGWLYISPRLTFPSLHALVEHYSELAD
GICCPLREPCVLQKLGPLPGKDTPPPVTVPTSSLNWKKLDRSLLFLEAPASGEASLLSEG
LRESLSSYISLAEDPLDDA
Gene Ontology
GO:0016023; C:cytoplasmic membrane-bounded vesicle; IDA:MGI
GO:0005770; C:late endosome; IDA:MGI
GO:0005886; C:plasma membrane; IDA:MGI
GO:0047485; F:protein N-terminus binding; ISS:UniProtKB
GO:0005070; F:SH3/SH2 adaptor activity; ISS:UniProtKB
GO:0050849; P:negative regulation of calcium-mediated signaling; IEA:Ensembl
GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; ISS:UniProtKB
GO:0042110; P:T cell activation; IDA:MGI
Interpro
InterPro; IPR000980; SH2
InterPro; IPR001452; SH3_domain
Pfam
Pfam; PF00017; SH2;
Pfam; PF00018; SH3_1;
SMART
SMART; SM00252; SH2;
SMART; SM00326; SH3;
PROSITE
PROSITE; PS50001; SH2;
PROSITE; PS50002; SH3;
PRINTS
PRINTS; PR00401; SH2DOMAIN;