| Tag |
Content |
LipidDB ID |
LipidDB-10090-00862 |
Entry Name |
|
UniProt Accession |
|
Theoretical PI |
5.4 |
Molecular Weight |
67318.05 |
Genbank Protein ID |
|
Genbank Nucleotide ID |
|
Protein Name |
Lamin-B2 |
Protein Synonyms/Alias |
|
Gene Name |
Lmnb2 |
Gene Synonyms/Alias |
|
Created Date |
01-MAY-1991 |
| Lipid Modification Sites |
|---|
| Position |
Sequence Form |
Peptide |
References |
Modification Type |
593 | Canonical | PRTTSRGCRLM**** | [1] | S-Farnesylation |
|
Organism |
Mus musculus (Mouse) |
NCBI Taxa ID |
10090 |
Reference |
[1] Jung HJ, Nobumori C, Goulbourne CN, Tu Y, Lee JM, Tatar A, Wu D, Yoshinaga Y, de Jong PJ, Coffinier C, Fong LG, Young SG. Farnesylation of lamin B1 isimportant for retention of nuclear chromatin during neuronal migration. Proc NatlAcad Sci U S A. 2013 May 21;110(21):E1923-32. doi: 10.1073/pnas.1303916110. Epub 2013 May 6.[ PMID:23650370]
|
Functional Description |
Lamins are components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane, which is thought to provide a framework for the nuclear envelope and may also interact with chromatin. |
Sequence Annotation |
Domain: 442 550 LTD.
Region: 1 26 Head.
Region: 27 378 Rod.
Region: 27 61 Coil 1A.
Region: 62 73 Linker 1.
Region: 74 207 Coil 1B.
Region: 208 234 Linker 2.
Region: 235 378 Coil 2.
Region: 379 596 Tail.
Motif: 415 420 Nuclear localization signal.
Modified residue: 12 12 Phosphothreonine.
Modified residue: 15 15 Phosphoserine.
Modified residue: 59 59 N6-acetyllysine.
Modified residue: 398 398 Phosphoserine.
Modified residue: 400 400 Phosphoserine.
Modified residue: 402 402 Phosphoserine.
Modified residue: 593 593 Cysteine methyl ester.
|
Protein Length |
596 AA. |
Protein Sequence
(Canonical) |
MASLPPHAGP ATPLSPTRLS RLQEKEELRE LNDRLAHYID RVRALELEND RLLLRISEKE 60
EVTTREVSGI KTLYESELAD ARRVLDETAR ERARLQIEIG KVQAELEEAR KSAKKREGEL 120
TVAQGRVKDL ESLFHRSEAE LATALSDKQG LETEVAELRA QLAKAEDGHA VAKKQLEKET 180
LMRVDLENRC QSLQEELAFS KSVFEEEVRE TRRRHERRLV EVDSSRQQEY DFKMAQALED 240
LRSQHDEQVR LYRVELEQTY QAKLDNAKLL SDQNDKAAHA AREELKEARM RVESLSYQLL 300
GLQKQASAAE NHIHELEEAL AGERDKFRKM LDAKEQEMTE VRDAMQQQLA EYQELLDIKL 360
ALDMEISAYR KLLEGEEERL KLSPSPSSRI TISRATSSSS SSSGVGMSVG QGRGKRRRLE 420
TEDTSGSPSR ASRVSSGSRL AQQTVATGVV NIDEVDPEGR FVRLKNSSDK DQSLGNWRIK 480
RQVLEGEDIA YKFTPKYVLR AGQTVTVWAA GAGATHSPPS TLVWKSQTNW GPGESFRTAL 540
VSADGEEVAV KAAKHSSVQG RENGEEEEEE EAEFGEEDLF HQQGDPRTTS RGCRLM 596
|
FASTA
(Canonical) |
>LipidDB-10090-00862|P21619
MASLPPHAGPATPLSPTRLSRLQEKEELRELNDRLAHYIDRVRALELENDRLLLRISEKE
EVTTREVSGIKTLYESELADARRVLDETARERARLQIEIGKVQAELEEARKSAKKREGEL
TVAQGRVKDLESLFHRSEAELATALSDKQGLETEVAELRAQLAKAEDGHAVAKKQLEKET
LMRVDLENRCQSLQEELAFSKSVFEEEVRETRRRHERRLVEVDSSRQQEYDFKMAQALED
LRSQHDEQVRLYRVELEQTYQAKLDNAKLLSDQNDKAAHAAREELKEARMRVESLSYQLL
GLQKQASAAENHIHELEEALAGERDKFRKMLDAKEQEMTEVRDAMQQQLAEYQELLDIKL
ALDMEISAYRKLLEGEEERLKLSPSPSSRITISRATSSSSSSSGVGMSVGQGRGKRRRLE
TEDTSGSPSRASRVSSGSRLAQQTVATGVVNIDEVDPEGRFVRLKNSSDKDQSLGNWRIK
RQVLEGEDIAYKFTPKYVLRAGQTVTVWAAGAGATHSPPSTLVWKSQTNWGPGESFRTAL
VSADGEEVAVKAAKHSSVQGRENGEEEEEEEAEFGEEDLFHQQGDPRTTSRGCRLM
|
Gene Ontology |
|
Interpro |
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Pfam |
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SMART |
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PROSITE |
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PRINTS |
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