LipidDB ID

LipidDB-10090-00857

Entry Name

UniProt Accession

P19785; Q9JJT5; Q9QY51; Q9QY52;

Theoretical PI

8.3

Molecular Weight

66954.91

Genbank Protein ID

AAA37580.1; BAC29510.1; BAC30973.1; CAB85618.1; AAF22562.1; AAF22561.1;

Genbank Nucleotide ID

M38651; AK036627; AK041525; AJ276597; AF128221; AF128220;

Protein Name

Estrogen receptor

Protein Synonyms/Alias

ER; ER-alpha; Estradiol receptor; Nuclear receptor subfamily 3 group A member 1;

Gene Name

Esr1

Gene Synonyms/Alias

Esr; Estr; Estra; Nr3a1;

Created Date

01-FEB-1991

Organism

Mus musculus (Mouse)

NCBI Taxa ID

10090

Reference

[1] Pedram A, Razandi M, Deschenes RJ, Levin ER. DHHC-7 and -21 arepalmitoylacyltransferases for sex steroid receptors. Mol Biol Cell. 2012Jan;23(1):188-99. doi: 10.1091/mbc.E11-07-0638. Epub 2011 Oct 26.[PMID:22031296]

Functional Description

Nuclear hormone receptor. The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Ligand-dependent nuclear transactivation involves either direct homodimer binding to a palindromic estrogen response element (ERE) sequence or association with other DNA- binding transcription factors, such as AP-1/c-Jun, c-Fos, ATF-2, Sp1 and Sp3, to mediate ERE-independent signaling. Ligand binding induces a conformational change allowing subsequent or combinatorial association with multiprotein coactivator complexes through LXXLL motifs of their respective components. Mutual transrepression occurs between the estrogen receptor (ER) and NF- kappa-B in a cell-type specific manner. Decreases NF-kappa-B DNA- binding activity and inhibits NF-kappa-B-mediated transcription from the IL6 promoter and displace RELA/p65 and associated coregulators from the promoter. Recruited to the NF-kappa-B response element of the CCL2 and IL8 promoters and can displace CREBBP. Present with NF-kappa-B components RELA/p65 and NFKB1/p50 on ERE sequences. Can also act synergistically with NF-kappa-B to activate transcription involving respective recruitment adjacent response elements; the function involves CREBBP. Can activate the transcriptional activity of TFF1. Also mediates membrane-initiated estrogen signaling involving various kinase cascades. Essential for MTA1-mediated transcriptional regulation of BRCA1 and BCAS3.

Sequence Annotation

Region: 1 188 Modulating (transactivation AF-1);mediates interaction with MACROD1.
Region: 35 178 Interaction with DDX5; self-association.
Region: 35 47 Required for interaction with NCOA1.
Region: 189 314 Mediates interaction with DNTTIP2.
Region: 255 314 Hinge.
Region: 266 599 Interaction with AKAP13.
Region: 268 599 Self-association.
Region: 315 599 Transactivation AF-2.
Region: 315 555 Steroid-binding.
Modified residue: 108 108 Phosphoserine; by CDK2.
Modified residue: 110 110 Phosphoserine; by CDK2.
Modified residue: 122 122 Phosphoserine.
Modified residue: 171 171 Phosphoserine; by CK2.
Modified residue: 264 264 Asymmetric dimethylarginine; by PRMT1.
Modified residue: 541 541 Phosphotyrosine; by Tyr-kinases.

Protein Length

599 AA.

Protein Sequence
(Canonical)

FASTA
(Canonical)

Gene Ontology

GO:0005737; C:cytoplasm; IDA:MGI
GO:0005794; C:Golgi apparatus; IEA:UniProtKB-KW
GO:0005634; C:nucleus; IDA:MGI
GO:0005886; C:plasma membrane; IEA:UniProtKB-KW
GO:0003682; F:chromatin binding; IDA:MGI
GO:0001046; F:core promoter sequence-specific DNA binding; IEA:Ensembl
GO:0034056; F:estrogen response element binding; IEA:Ensembl
GO:0038052; F:estrogen-activated sequence-specific DNA binding RNA polymerase II transcription factor activity; IEA:Ensembl
GO:0004879; F:ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity; IDA:MGI
GO:0000978; F:RNA polymerase II core promoter proximal region sequence-specific DNA binding; IEA:Ensembl
GO:0001077; F:RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription; IEA:Ensembl
GO:0005496; F:steroid binding; ISS:UniProtKB
GO:0008134; F:transcription factor binding; IPI:UniProtKB
GO:0008270; F:zinc ion binding; IEA:InterPro
GO:0008209; P:androgen metabolic process; IMP:MGI
GO:0001547; P:antral ovarian follicle growth; IMP:MGI
GO:0016049; P:cell growth; NAS:UniProtKB
GO:0071392; P:cellular response to estradiol stimulus; ISS:UniProtKB
GO:0071391; P:cellular response to estrogen stimulus; IMP:MGI
GO:0002064; P:epithelial cell development; IMP:MGI
GO:0060750; P:epithelial cell proliferation involved in mammary gland duct elongation; IMP:MGI
GO:0030518; P:intracellular steroid hormone receptor signaling pathway; ISS:UniProtKB
GO:0008584; P:male gonad development; IMP:MGI
GO:0060749; P:mammary gland alveolus development; IMP:MGI
GO:0060745; P:mammary gland branching involved in pregnancy; IMP:MGI
GO:0010629; P:negative regulation of gene expression; IEA:Ensembl
GO:0043124; P:negative regulation of I-kappaB kinase/NF-kappaB signaling; ISS:UniProtKB
GO:0045839; P:negative regulation of mitosis; NAS:UniProtKB
GO:0043433; P:negative regulation of sequence-specific DNA binding transcription factor activity; ISS:UniProtKB
GO:0007200; P:phospholipase C-activating G-protein coupled receptor signaling pathway; ISS:UniProtKB
GO:0007204; P:positive regulation of cytosolic calcium ion concentration; ISS:UniProtKB
GO:0048146; P:positive regulation of fibroblast proliferation; IMP:MGI
GO:0045429; P:positive regulation of nitric oxide biosynthetic process; ISS:UniProtKB
GO:0051000; P:positive regulation of nitric-oxide synthase activity; ISS:UniProtKB
GO:0010863; P:positive regulation of phospholipase C activity; ISS:UniProtKB
GO:0048386; P:positive regulation of retinoic acid receptor signaling pathway; IEA:Ensembl
GO:0051091; P:positive regulation of sequence-specific DNA binding transcription factor activity; ISS:UniProtKB
GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IMP:MGI
GO:0060527; P:prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis; IMP:MGI
GO:0060523; P:prostate epithelial cord elongation; IMP:MGI
GO:0042981; P:regulation of apoptotic process; IMP:MGI
GO:0060687; P:regulation of branching involved in prostate gland morphogenesis; IMP:MGI
GO:0006355; P:regulation of transcription, DNA-templated; IDA:MGI
GO:0060065; P:uterus development; IGI:MGI
GO:0060068; P:vagina development; IGI:MGI

Interpro

InterPro; IPR008946; Nucl_hormone_rcpt_ligand-bd
InterPro; IPR000536; Nucl_hrmn_rcpt_lig-bd_core
InterPro; IPR024178; Oest_rcpt/oest-rel_rcp
InterPro; IPR001292; Oestr_rcpt
InterPro; IPR024736; Oestrogen-typ_rcpt_final_C_dom
InterPro; IPR001723; Str_hrmn_rcpt
InterPro; IPR001628; Znf_hrmn_rcpt
InterPro; IPR013088; Znf_NHR/GATA

Pfam

Pfam; PF12743; ESR1_C;
Pfam; PF00104; Hormone_recep;
Pfam; PF02159; Oest_recep;
Pfam; PF00105; zf-C4;

SMART

SMART; SM00430; HOLI;
SMART; SM00399; ZnF_C4;

PROSITE

PROSITE; PS00031; NUCLEAR_REC_DBD_1;
PROSITE; PS51030; NUCLEAR_REC_DBD_2;

PRINTS

PRINTS; PR00543; OESTROGENR;
PRINTS; PR00398; STRDHORMONER;
PRINTS; PR00047; STROIDFINGER;