Lipid Modification Database
Tag Content
LipidDB ID
LipidDB-10090-00838
Entry Name
UniProt Accession
Theoretical PI
4.73
Molecular Weight
20504.36
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
Ras-related protein Rap-2b
Protein Synonyms/Alias
Gene Name
Rap2b
Gene Synonyms/Alias
Created Date
10-MAY-2004
 Lipid Modification Sites 
 Position   Sequence Form   Peptide   References   Modification Type 
176
Canonical
QPNGDEGCCSACVIL
[1]
S-Palmitoylation
177
Canonical
PNGDEGCCSACVIL*
[1]
S-Palmitoylation
Organism
Mus musculus (Mouse)
NCBI Taxa ID
10090
Reference
[1] Predicted from GPS-Lipid
Functional Description
Small GTP-binding protein which cycles between a GDP- bound inactive and a GTP-bound active form. Involved in EGFR and CHRM3 signaling pathways through stimulation of PLCE1. May play a role in cytoskeletal rearrangements and regulate cell spreading through activation of the effector TNIK. May regulate membrane vesiculation in red blood cells.
Sequence Annotation
Nucleotide-binding: 10 17 GTP.
Nucleotide-binding: 57 61 GTP.
Nucleotide-binding: 116 119 GTP.
Motif: 32 40 Effector region.
Modified residue: 180 180 Cysteine methyl ester.
Protein Length
183 AA.
Protein Sequence
(Canonical)
MREYKVVVLG SGGVGKSALT VQFVTGSFIE KYDPTIEDFY RKEIEVDSSP SVLEILDTAG  60
TEQFASMRDL YIKNGQGFIL VYSLVNQQSF QDIKPMRDQI IRVKRYERVP MILVGNKVDL  120
EGEREVSYGE GKALAEEWSC PFMETSAKNK ASVDELFAEI VRQMNYAAQP NGDEGCCSAC  180
VIL                                                                183
FASTA
(Canonical)
>LipidDB-10090-00838|P61226
MREYKVVVLGSGGVGKSALTVQFVTGSFIEKYDPTIEDFYRKEIEVDSSPSVLEILDTAG
TEQFASMRDLYIKNGQGFILVYSLVNQQSFQDIKPMRDQIIRVKRYERVPMILVGNKVDL
EGEREVSYGEGKALAEEWSCPFMETSAKNKASVDELFAEIVRQMNYAAQPNGDEGCCSAC
VIL
Gene Ontology
GO:0005829; C:cytosol; IDA:MGI
GO:0070062; C:extracellular vesicular exosome; IEA:Ensembl
GO:0016020; C:membrane; IDA:MGI
GO:0005886; C:plasma membrane; IEA:Ensembl
GO:0055037; C:recycling endosome; IDA:MGI
GO:0055038; C:recycling endosome membrane; IDA:UniProtKB
GO:0019003; F:GDP binding; IEA:Ensembl
GO:0005525; F:GTP binding; IEA:UniProtKB-KW
GO:0019904; F:protein domain specific binding; IPI:MGI
GO:0006184; P:GTP catabolic process; IEA:InterPro
GO:0030336; P:negative regulation of cell migration; IDA:MGI
GO:0031954; P:positive regulation of protein autophosphorylation; IDA:MGI
GO:0032486; P:Rap protein signal transduction; IDA:UniProtKB
GO:0061097; P:regulation of protein tyrosine kinase activity; IDA:UniProtKB
Interpro
InterPro; IPR027417; P-loop_NTPase
InterPro; IPR005225; Small_GTP-bd_dom
InterPro; IPR001806; Small_GTPase
InterPro; IPR020849; Small_GTPase_Ras
Pfam
Pfam; PF00071; Ras;
SMART
SMART; SM00173; RAS;
PROSITE
PROSITE; PS51421; RAS;
PRINTS
PRINTS; PR00449; RASTRNSFRMNG;