LipidDB ID

LipidDB-10090-00816

Entry Name

UniProt Accession

P28667; Q3TEZ4; Q91W07;

Theoretical PI

4.6

Molecular Weight

20165.43

Genbank Protein ID

CAA43671.1; AAP13962.1; BAC37630.1; BAC39058.1; BAE31636.1; BAE41104.1; AAH06757.1;

Genbank Nucleotide ID

X61399; S65597; AK079390; AK083913; AK152990; AK169355; BC006757;

Protein Name

MARCKS-related protein

Protein Synonyms/Alias

Brain protein F52; MARCKS-like protein 1; Macrophage myristoylated alanine-rich C kinase substrate; Mac-MARCKS; MacMARCKS;

Gene Name

Marcksl1

Gene Synonyms/Alias

Mlp; Mrp;

Created Date

01-DEC-1992

Organism

Mus musculus (Mouse)

NCBI Taxa ID

10090

Reference

[1] Bähr G, Diederich A, Vergères G, Winterhalter M. Interaction of the effectordomain of MARCKS and MARCKS-related protein with lipid membranes revealed byelectric potential measurements. Biochemistry. 1998 Nov 17;37(46):16252-61.[PMID:9819217]

Functional Description

Controls cell movement by regulating actin cytoskeleton homeostasis and filopodium and lamellipodium formation. When unphosphorylated, induces cell migration. When phosphorylated by MAPK8, induces actin bundles formation and stabilization, thereby reducing actin plasticity, hence restricting cell movement, including neuronal migration. May also affect cancer cell migration. May be involved in coupling the protein kinase C and calmodulin signal transduction systems.

Sequence Annotation

Region: 87 110 Effector domain involved in lipid-binding.
Region: 87 100 Calmodulin-binding (PSD).
Modified residue: 22 22 Phosphoserine.
Modified residue: 36 36 Phosphoserine.
Modified residue: 48 48 Phosphoserine.
Modified residue: 71 71 Phosphoserine.
Modified residue: 85 85 Phosphothreonine.
Modified residue: 93 93 Phosphoserine; by PKC.
Modified residue: 101 101 Phosphoserine; by PKC.
Modified residue: 104 104 Phosphoserine; by PKC.
Modified residue: 120 120 Phosphoserine; by MAPK8.
Modified residue: 135 135 Phosphoserine.
Modified residue: 148 148 Phosphothreonine; by MAPK8.
Modified residue: 151 151 Phosphoserine.
Modified residue: 162 162 Phosphoserine.
Modified residue: 165 165 Phosphoserine.
Modified residue: 170 170 Phosphothreonine.
Modified residue: 183 183 Phosphothreonine; by MAPK8.
Modified residue: 192 192 Phosphothreonine.

Protein Length

200 AA.

Protein Sequence
(Canonical)

FASTA
(Canonical)

Gene Ontology

GO:0005737; C:cytoplasm; IEA:UniProtKB-KW
GO:0070062; C:extracellular vesicular exosome; IEA:Ensembl
GO:0005886; C:plasma membrane; IEA:UniProtKB-KW
GO:0008284; P:positive regulation of cell proliferation; IDA:MGI

Interpro

InterPro; IPR002101; MARCKS

Pfam

Pfam; PF02063; MARCKS;

SMART

PROSITE

PROSITE; PS00826; MARCKS_1;
PROSITE; PS00827; MARCKS_2;

PRINTS

PRINTS; PR00963; MARCKS;