Lipid Modification Database
Tag Content
LipidDB ID
LipidDB-10090-00781
Entry Name
UniProt Accession
Theoretical PI
4.73
Molecular Weight
22876.24
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
Linker for activation of T-cells family member 2
Protein Synonyms/Alias
Linker for activation of B-cells; Membrane-associated adapter molecule; Non-T-cell activation linker; Williams-Beuren syndrome chromosomal region 15 protein homolog;
Gene Name
Lat2
Gene Synonyms/Alias
Lab; Ntal; Wbscr15; Wbscr5;
Created Date
20-DEC-2005
 Lipid Modification Sites 
 Position   Sequence Form   Peptide   References   Modification Type 
29
Canonical
TAWLCVHCSRPGVKR
[1]
S-Palmitoylation
Organism
Mus musculus (Mouse)
NCBI Taxa ID
10090
Reference
[1] Predicted from GPS-Lipid
Functional Description
Involved in FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. May also be involved in BCR (B-cell antigen receptor)-mediated signaling in B-cells and FCGR1 (high affinity immunoglobulin gamma Fc receptor I)-mediated signaling in myeloid cells. Couples activation of these receptors and their associated kinases with distal intracellular events through the recruitment of GRB2.
Sequence Annotation
Topological domain: 1 6 Extracellular.
Transmembrane: 7 27 Helical; Signal-anchor for type IIImembrane protein.
Topological domain: 28 203 Cytoplasmic.
Modified residue: 59 59 Phosphotyrosine.
Modified residue: 60 60 Phosphoserine.
Modified residue: 95 95 Phosphoserine.
Modified residue: 192 192 Phosphotyrosine.
Protein Length
203 AA.
Protein Sequence
(Canonical)
MSAELELLWP VSGLLLLLLG ATAWLCVHCS RPGVKRNEKI YEQRNRQENA QSSAAAQTYS  60
LARQVWPGPQ MDTAPNKSFE RKNKMLFSHL EGPESPRYQN FYKGSNQEPD AAYVDPIPTN  120
YYNWGCFQKP SEDDDSNSYE NVLVCKPSTP ESGVEDFEDY QNSVSIHQWR ESKRTMGAPM  180
SLSGSPDEEP DYVNGDVAAA ENI                                          203
FASTA
(Canonical)
>LipidDB-10090-00781|Q9JHL0
MSAELELLWPVSGLLLLLLGATAWLCVHCSRPGVKRNEKIYEQRNRQENAQSSAAAQTYS
LARQVWPGPQMDTAPNKSFERKNKMLFSHLEGPESPRYQNFYKGSNQEPDAAYVDPIPTN
YYNWGCFQKPSEDDDSNSYENVLVCKPSTPESGVEDFEDYQNSVSIHQWRESKRTMGAPM
SLSGSPDEEPDYVNGDVAAAENI
Gene Ontology
GO:0070062; C:extracellular vesicular exosome; IEA:Ensembl
GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW
GO:0042629; C:mast cell granule; IEA:GOC
GO:0045121; C:membrane raft; ISS:HGNC
GO:0005886; C:plasma membrane; IEA:UniProtKB-KW
GO:0042169; F:SH2 domain binding; ISS:HGNC
GO:0042113; P:B cell activation; ISS:HGNC
GO:0050853; P:B cell receptor signaling pathway; ISS:HGNC
GO:0019722; P:calcium-mediated signaling; ISS:HGNC
GO:0035556; P:intracellular signal transduction; ISS:HGNC
GO:0043303; P:mast cell degranulation; IEA:UniProtKB-KW
Interpro
Pfam
SMART
PROSITE
PRINTS